Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(43), P. 11110 - 11122
Published: Jan. 1, 2024
The
challenge
of
enhancing
wound
healing
and
skin
regeneration,
particularly
in
conditions
like
burns
diabetic
wounds,
necessitates
innovative
solutions.
Cholesterol,
often
associated
with
cardiovascular
diseases,
plays
vital
roles
cellular
functions,
maintaining
integrity
preserving
the
barrier.
Here,
we
explore
cholesterol's
significance,
its
influence
on
keratinocytes,
potential
application
regeneration.
study
utilizes
electrospun
polyimide
(PI)
fibers
as
a
cholesterol
carrier
model
investigates
impact
HaCaT
marking
first
time
tracked
delivery
from
scaffold
into
cells.
We
demonstrate
that
an
optimal
concentration
0.7
mM
medium
enhances
cell
proliferation,
while
higher
concentrations
have
negative
effects.
Cholesterol-enriched
scaffolds
significantly
increase
proliferation
replicative
activity,
especially
3D
culture
environment.
Moreover,
influences
keratinocyte
differentiation,
promoting
early
differentiation
inhibiting
late
differentiation.
These
findings
suggest
cholesterol-loaded
can
applications
by
growth,
regulating
potentially
accelerating
closure.
Further
research
this
area
will
lead
to
management
tissue
regeneration
strategies.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(38)
Published: July 26, 2024
Abstract
In
recent
years,
advancements
in
microbial
sequencing
technology
have
sparked
an
increasing
interest
the
bacteria
residing
within
solid
tumors
and
its
distribution
functions
various
tumors.
Intratumoral
critically
modulate
tumor
oncogenesis
development
through
DNA
damage
induction,
chronic
inflammation,
epigenetic
alterations,
metabolic
immune
regulation,
while
also
influencing
cancer
treatment
efficacy
by
affecting
drug
metabolism.
response
to
these
discoveries,
a
variety
of
anti‐cancer
therapies
targeting
microorganisms
emerged.
These
approaches
encompass
oncolytic
therapy
utilizing
tumor‐associated
bacteria,
design
biomaterials
based
on
intratumoral
use
bacterial
components
for
delivery
systems,
comprehensive
strategies
aimed
at
eradication
tumor‐promoting
bacteria.
Herein,
this
review
article
summarizes
patterns
different
tumors,
examines
their
impact
evaluates
current
therapeutic
centered
Furthermore,
challenges
prospects
developing
drugs
that
target
communities
are
explored,
promising
new
directions
treatment.
Advanced Materials Interfaces,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 5, 2025
Abstract
Rapid
advances
in
the
development
of
nanotechnology
recent
years
have
led
to
functional
magnetic
nanoparticle
types
(MNPs)
with
different
properties.
The
diverse
applications
these
nanoparticles
make
them
a
desirable
candidate
for
use
biomedical
areas
due
their
exclusive
chemical
and
physical
present
work
is
conducted
study
vitro
biocompatibility
CoFe
2
O
4
@shell
surface
coatings
(shell:
ascorbic
acid
(AA),
dextran
(DEX),
polyethyleneimine
(PEI).
cytotoxicity
coated
screened
toward
glioma
cancer
line
(C6)
fibroblast
cell
(L929)
using
an
MTT
assay.
NPs
are
synthesized
co‐precipitation
method
together
hydrothermal
synthesis
characterized
regarding
structural
properties
state‐of‐the‐art
techniques.
Results
showed
particles
consistent
crystal
structure
average
crystallite
size
range
16–18
nm.
For
NPs,
only
slight
increase
Hc
found
except
@PEI
NPs.
comparative
analysis
cytotoxic
effects
on
L929
cells
shows
that
samples
much
more
specific
brain
tumor
cells,
especially
it
also
indicates
significant
efficacy
cells.
Aggregate,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 15, 2025
ABSTRACT
Colorectal
cancer
(CRC)
screening
and
early
diagnosis
is
an
effective
strategy
for
reducing
CRC
mortality.
However,
the
current
detection
methods
involve
exorbitant
costs
complex
procedures,
which
are
inconvenient
large‐scale
screening.
Given
its
high
prevalence
in
malignant
tissues
feces
of
patients,
Fusobacterium
nucleatum
(
F.
)
has
emerged
as
a
crucial
biomarker
CRC.
Herein,
we
propose
‐specific
recognition
diagnosis.
A
novel
nanobioprobe
(AIE‐Pep)
with
aggregation‐induced
emission
(AIE)
characteristics
was
synthesized
by
conjugating
red/near‐infrared
(NIR)
emissive
AIE
luminogen
(AIEgen)
FadA‐targeting
peptide
(ASANWTIQYND).
The
robust
binding
affinity
between
FadA
on
allows
AIE‐Pep
NPs
to
adhere
selectively
,
emits
strong
red/NIR
fluorescence.
In
model
orthotopic
CRC,
can
precisely
localize
around
Moreover,
demonstrated
limit
(LOD)
82.97
CFU/mL
could
significantly
differentiate
mice
from
those
normal
mice.
Overall,
this
study
presents
pivotal
approach
specifically
identifying
holds
immense
potential
Exploration,
Journal Year:
2023,
Volume and Issue:
4(1)
Published: Dec. 22, 2023
Abstract
Colorectal
cancer
(CRC)
is
generally
characterized
by
a
high
prevalence
of
Fusobacterium
nucleatum
(
F.
),
spindle‐shaped,
Gram‐negative
anaerobe
pathogen
derived
from
the
oral
cavity.
This
tumor‐resident
microorganism
has
been
closely
correlated
with
occurrence,
progression,
chemoresistance
and
immunosuppressive
microenvironment
CRC.
Furthermore,
can
specifically
colonize
CRC
tissues
through
adhesion
on
its
surface,
forming
biofilms
that
are
highly
resistant
to
commonly
used
antibiotics.
Accordingly,
it
crucial
develop
efficacious
non‐antibiotic
approaches
eradicate
for
treatment.
In
recent
years,
various
antimicrobial
strategies,
such
as
natural
extracts,
inorganic
chemicals,
organic
polymers,
inorganic‐organic
hybrid
materials,
bacteriophages,
probiotics,
vaccines,
have
proposed
combat
biofilms.
review
summarizes
latest
advancements
in
anti‐
research,
elucidates
mechanisms
employed
these
systems,
discusses
benefits
drawbacks
each
technology.
Additionally,
this
also
provides
an
outlook
specificity,
potential
clinical
implications,
challenges,
future
improvements
strategies
treatment
