Medical Cannabis and Cannabinoids,
Год журнала:
2024,
Номер
7(1), С. 149 - 159
Опубликована: Авг. 28, 2024
Introduction:
Approximately
4%
of
the
UK
population
experiences
PTSD.
Individuals
must
exhibit
symptoms
across
four
clusters
to
receive
a
diagnosis:
intrusion,
avoidance,
altered
reactivity,
and
mood.
Evidence
suggests
that
cannabinoid
agonists
such
as
nabilone
tetrahydrocannabinol
(THC)
may
alleviate
PTSD
symptoms.
We
investigated
safety
effectiveness
THC-predominant
cannabis
flowers
for
inhalation
manage
in
real-world
setting.
Methods:
analysed
data
from
patient
registry,
T21.
Validated
questionnaires
were
used
collect
PROMs
health-related
quality
life
(HRQoL),
mood/anxiety,
sleep,
PTSD-specific
Inclusion
criteria
(i)
confirmed
diagnosis
PTSD,
(ii)
completed
at
baseline
3-month
follow-up,
(iii)
received
prescription
chemotype
1
(THC-predominant)
flower.
Results:
Fifty-eight
patients
included,
34
which
also
had
recorded
6
months.
Most
males
(65.5%)
with
an
average
age
39.2
years
who
previously
illicitly
(95.6%).
At
3
months,
participants
reported
significant
improvements
overall
health,
mood,
sleep
(p
<
0.001)
but
not
proxy
HRQoL
=
0.052).
Similarly,
substantial
benefits
managing
intrusion
0.001),
mood
alterations
reactivity
0.002),
sustained
or
further
improved
Participants
did
report
any
side
effects
associated
CBMPs.
Conclusions:
Inhalation
THC
is
well
tolerated
useful
cannabis-experienced
individuals.
However,
research
needed
evaluate
long-term
outcomes
controlled
CBMP
naïve
cannabis.
Frontiers in Public Health,
Год журнала:
2024,
Номер
11
Опубликована: Янв. 5, 2024
Background
There
are
well-established
literatures
documenting
the
associations
between
mental
disorders
and
unhealthy
behaviors
such
as
poor
diet
quality,
sedentary
behavior,
cannabis
tobacco
use.
Few
studies
have
attempted
to
understand
respective
findings
in
light
of
each
other,
however.
Objective
The
purpose
this
review
was
assemble
comparable
data
for
behavior-disorder
association
assess
terms
their
overall
strength.
aimed
include
a
representative,
but
not
exhaustive,
range
that
would
allow
explorative
comparisons.
Methods
Eligible
were
identified
via
Pubmed
searches
citation
searching,
restricted
publications
no
older
than
2015
written
English.
To
obtain
data,
only
reported
odds
ratios
included,
risk
bias
related
study
samples,
behavioral
measurement
disparities,
control
variables
assessed
sensitivity
analyses.
Findings
disorder
compared
on
basis
different
measures
central
tendency.
Results
From
3,682
records,
294
included.
found
evidence
four
psychosis,
depression,
anxiety,
bipolar
disorder,
attention-deficit/hyperactivity
(ADHD),
post-traumatic
stress
(PTSD),
while
personality
investigated
relation
In
comparison,
generally
similar
strength,
use
exceptional
being
significantly
stronger
its
counterparts
across
behaviors.
Analyses
some
influence
from
disparities
lack
adequate
statistical
control,
robust
Conclusion
This
comparative
about
equally
strongly
associated
with
disorders.
Given
general
nature
these
associations,
we
should
probably
them
reflect
shared
etiology.
However,
be
regarded
tentative
until
confirmed
by
more
comprehensive
investigations.
Journal of Cannabis Research,
Год журнала:
2025,
Номер
7(1)
Опубликована: Янв. 25, 2025
Abstract
Introduction
Chronic
pain
is
common
among
Veterans,
some
of
whom
use
cannabis
for
pain.
We
conducted
a
feasibility
pilot
study
novel
coaching
intervention
to
help
Veterans
optimize
medical
products
management
(NCT06320470).
Methods
The
drew
from
scientific
literature,
consultation
with
experts,
Veteran
input
via
Community
Advisory
Board,
and
tenets
motivational
interviewing.
Participants
were
chronic
who
endorsed
current
or
interest
in
using
management.
received
up
4
individual
sessions
videoconference,
spaced
approximately
2
weeks
apart.
assessed
(adherence,
satisfaction,
acceptability)
preliminary
effects
on
symptoms
14
after
baseline.
primary
outcome
was
the
Patient
Global
Impression
Change
(PGIC),
exploratory
outcomes
included
domains
Patient-Reported
Outcomes
Measurement
Information
System
(PROMIS)-29.
Results
Of
22
enrolled
participants,
17
attended
sessions,
3
sessions.
Among
those
completed
end
surveys
(16/21),
87.5%
very
completely
satisfied
81.3%
rated
as
extremely
helpful.
All
participants
reported
improvement
PGIC,
63%
reporting
much
improvement.
statistically
significant
decreased
intensity
(7.1/10
vs.
5.7/10)
interference
(T-score
66.3
61.8),
increased
social
satisfaction
41.4
44.3).
noted
helpful
factors,
including
co-developing
personalized
plan,
discussing
questions/concerns,
trying
different
approaches
cannabis-based
treatment.
Conclusions
In
this
clinically
improvements
symptoms.
Our
results
support
evaluating
larger,
efficacy
trial.
Objective:
While
cannabis
use
is
common
among
people
with
HIV
(PWH),
there
have
been
few
studies
examining
the
association
of
health
outcomes
PWH.
We
aimed
to
evaluate
between
and
bothersome
physical
mental
symptoms
using
both
self-report
a
direct
biomarker
for
use.
Method:
The
Medications,
Alcohol
Substance
in
Study
(MASH)
cross-cohort
study
focused
on
polypharmacy
substance
Participants
were
enrolled
from
October
2018
May
2022
Swiss
Cohort
(SHCS),
Kaiser
Permanente
Northern
California
(KPNC)
Cohort,
7
sites
(Atlanta,
GA;
Bronx,
NY;
Washington,
DC;
Houston,
TX;
Los
Angeles,
CA;
New
York,
Nashville,
TN)
Veterans
Aging
-
(VACS-HIV).
submitted
self-reported
information
presence/absence
prior
4
weeks,
along
level,
Symptom
Index,
which
comprised
20
commonly
reported
PWH,
including
fatigue,
diarrhea,
fever,
anxiety,
weight
loss,
others.
Concurrent
was
also
collected,
participants
provided
nail
clippings
be
tested
used
logistic
regression
models,
adjusted
age,
sex,
race/ethnicity,
cohort,
examine
associations
biomarker-identified
symptoms.
Results:
analytic
sample
included
1,226
PWH
who
predominantly
male
(85%),
non-white
(64%),
an
average
age
57
years;
20%
positive
use,
23%
recent
Agreement
substantial
(agreement
89%,
kappa
=
0.67).
Put
together,
27%
either
or
positive.
Of
19
more
prevalent
at
level
those
compared
without.
In
patterns
remained
biomarker-confirmed
they
particularly
memory,
depression,
nausea.
Conclusions:
Cannabis
associated
number
may
treat
loss
appetite,
nausea/vomiting,
memory
are
concerning
deserve
investigation.
Substance Use & Misuse,
Год журнала:
2025,
Номер
unknown, С. 1 - 10
Опубликована: Фев. 2, 2025
Background:
Research
suggests
that
individuals
who
experience
four
or
more
adverse
childhood
experiences
(ACEs)
have
increased
rates
of
cannabis
use.
However,
most
prior
research
does
not
separate
recreational
and
medical
usage.
Medical
is
used
legally
in
many
states
to
treat
a
variety
health
conditions,
which
are
also
associated
with
ACEs.
Objectives:
Therefore,
we
explore
the
extent
users
differ
from
whether
use
ACEs,
poor
health,
disability.
Accordingly,
ask
following
questions:
Are
ACEs
any
when
controlling
for
measures
disability?
use?
associations
between
explained
by
and/or
Results:
Using
2019
BRFSS
data,
find
significantly
use,
but
disability
fully
account
effect
on
Conclusions:
We
conclude
practitioners
screen
status
prescribing
cannabis.
Substance Use & Misuse,
Год журнала:
2023,
Номер
58(7), С. 858 - 870
Опубликована: Апрель 25, 2023
Background:
Substance
use
(SU)
is
associated
with
physical
injury
and
mental
health
disorders
in
older
persons,
but
recent
research
has
scarcely
examined
SU
U.S.
Vietnam-era
veterans
who
are
mostly
or
near
their
eighth
decade
of
life.
Objectives:
We
compared
the
prevalence
self-reported
lifetime
current
modeled
usage
patterns
a
nationally
representative
sample
versus
matched
nonveteran
cohort.
Methods:
Cross-sectional,
survey
data
were
analyzed
from
2016–2017
Vietnam
Era
Health
Retrospective
Observational
Study
(VE-HEROeS)
(n
=
18,866
veterans,
n
4,530
nonveterans).
assessed
alcohol
drug
disorders;
cannabis,
opioids,
stimulants,
sedatives,
"other
drugs"
(psychedelics,
prescription
over-the-counter
drugs
not
prescribed/used
as
intended);
(alcohol-use-only,
drug-use-only,
dual-SU,
no
SU).
Weighted
descriptive,
bivariable,
multivariable
statistics
calculated.
Covariates
multinomial
modeling
included
sociodemographic
characteristics,
cigarette
smoking,
depression,
potentially
traumatic
events
(PTEs),
pain
(SF-8TM).
Results:
Prevalence
opioid
sedative
(p
≤
.01),
<
.001),
drug"
.001)
higher
nonveterans.
Current
cannabis
was
high
both
cohorts.
In
very
severe/severe
pain,
PTEs
highly
drug-use-only
dual-SU
these
associations
fewer
for
Conclusion:
This
confirmed
existing
concerns
over
substance
misuse
individuals.
may
be
at
particular
risk
due
to
service-related
experiences
later-life
tribulations.
veterans'
unique
perceptions
toward
healthcare
assistance
need
greater
provider
focus
maximize
self-efficacy
treatment.
Frontiers in Neurology,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 12, 2024
Studies
have
demonstrated
that
individuals
diagnosed
with
traumatic
brain
injury
(TBI)
frequently
use
medical
and
recreational
cannabis
to
treat
persistent
symptoms
of
TBI,
such
as
chronic
pain
sleep
disturbances,
which
can
lead
disorder
(CUD).
We
aimed
determine
the
Veterans
Health
Administration
(VHA)
healthcare
utilization
costs
associated
CUD
dementia
diagnosis
in
veterans
TBI.
This
observational
study
used
administrative
datasets
from
population
post-9/11
Long-term
Impact
Military-Relevant
Brain
Injury
Consortium-Chronic
Effects
Neurotrauma
Consortium
VA
Data
Warehouse.
compared
differential
VHA
among
following
cohorts
veterans:
(1)
No
group,
(2)
Dementia
only
(Dementia
only),
(3)
only,
(4)
comorbid
CUD).
Generalized
estimating
equations
negative
binomial
regression
models
were
estimate
total
annual
(inflation-adjusted)
incidence
rate
utilization,
respectively,
by
status.
387,770
TBI
(88.4%
men;
median
[interquartile
range
(IQR)]
age
at
time
TBI:
30
[14]
years;
63.5%
white)
followed
2000
2020.
Overall,
we
observed
a
trend
gradually
increasing
5
years
after
onset.
Interestingly,
this
cohort
within
substantial
group
(peak
=
$46,808)
not
group.
Relative
those
without
either
condition,
$3,368
higher
while
no
significant
differences
groups.
The
findings
suggest
might
be
getting
their
needs
met
more
quickly
diagnosis,
whereas
are
receiving
early
care,
resulting
long-term
costs.
Further
investigations
should
examine
what
impact
timing
diagnoses
on
specific
categories
inpatient
outpatient
care
community
facilities.
Cell Reports,
Год журнала:
2023,
Номер
42(3), С. 112247 - 112247
Опубликована: Март 1, 2023
Endogenous
cannabinoid
signaling
is
vital
for
important
brain
functions,
and
the
same
pathways
can
be
modified
pharmacologically
to
treat
pain,
epilepsy,
posttraumatic
stress
disorder.
Endocannabinoid-mediated
changes
excitability
are
predominantly
attributed
2-arachidonoylglycerol
(2-AG)
acting
presynaptically
via
canonical
receptor,
CB1.
Here,
we
identify
a
mechanism
in
neocortex
by
which
anandamide
(AEA),
another
major
endocannabinoid,
but
not
2-AG,
powerfully
inhibits
somatically
recorded
voltage-gated
sodium
channel
(VGSC)
currents
majority
of
neurons.
This
pathway
involves
intracellular
CB1
that,
when
activated
anandamide,
decreases
likelihood
recurrent
action
potential
generation.
WIN
55,212-2
similarly
activates
VGSC
currents,
indicating
that
this
also
positioned
mediate
actions
exogenous
cannabinoids
on
neuronal
excitability.
The
coupling
between
VGSCs
absent
at
nerve
terminals,
2-AG
does
block
somatic
functional
compartmentalization
two
endocannabinoids.
