Chemical Society Reviews,
Год журнала:
2021,
Номер
50(10), С. 6013 - 6041
Опубликована: Янв. 1, 2021
In
this
review,
we
systematically
survey
the
most
recent
progress
in
engineering
nanomedicine
for
intracellular
glutathione
consumption-augmented
cancer
therapy.
Biomedicines,
Год журнала:
2021,
Номер
9(3), С. 305 - 305
Опубликована: Март 16, 2021
Photothermal
therapy
(PTT)
has
attracted
extensive
research
attention
as
a
noninvasive
and
selective
treatment
strategy
for
numerous
cancers.
PTT
functions
via
photothermal
effects
induced
by
converting
light
energy
into
heat
on
near-infrared
laser
irradiation.
Despite
the
great
advances
in
cancer
treatment,
therapeutics
using
devise
only
or
non-specific
small
molecule
agents
been
limited
because
of
its
low
conversion
efficiency,
concerns
about
biosafety
agents,
their
tumor
accumulation,
resistance
specific
types
cancer.
Using
nanomaterials
themselves,
delivery
offers
improved
therapeutic
outcomes
with
fewer
side
through
enhanced
accumulation
agent
tissue,
and,
extension,
combination
other
therapies.
Herein,
we
review
PTT’s
current
clinical
progress
present
future
outlooks
applications.
To
better
understand
applications,
describe
nanomaterial-mediated
mechanism
action
microenvironment.
This
also
summarizes
recent
studies
alone
Overall,
innovative
strategically
designed
platforms
are
promising
next-generation
treatments
to
move
closer
toward
Chemical Reviews,
Год журнала:
2016,
Номер
116(19), С. 12536 - 12563
Опубликована: Сен. 29, 2016
Advanced
drug
delivery
systems
(DDS)
enhance
treatment
efficacy
of
different
therapeutics
in
a
dosage,
spatial,
and/or
temporal
controlled
manner.
To
date,
numerous
chemical-
or
physical-based
stimuli-responsive
formulations
devices
for
release
have
been
developed.
Among
them,
the
emerging
mechanical
force-based
stimulus
offers
convenient
and
robust
platform
has
attracted
increasing
attention.
The
relevant
DDS
can
be
activated
to
promote
by
types
stimuli,
including
compressive
force,
tensile
shear
force
as
well
indirect
formats,
remotely
triggered
ultrasound
magnetic
field.
In
this
review,
we
provide
an
overview
recent
advances
mechanically
DDS.
opportunities
challenges
regarding
clinical
translations
are
also
discussed.
Advanced Materials,
Год журнала:
2017,
Номер
29(29)
Опубликована: Май 26, 2017
Cancer
immunotherapy,
as
a
paradigm
shift
in
cancer
treatment,
has
recently
received
tremendous
attention.
The
active
vaccination,
immune
checkpoint
blockage
(ICB)
and
chimeric
antigen
receptor
(CAR)
for
T-cell-based
adoptive
cell
transfer
are
among
these
developments
that
have
achieved
significant
increase
patient
survival
clinical
trials.
Despite
advancements,
emerging
research
at
the
interdisciplinary
interface
of
biology,
immunology,
bioengineering,
materials
science
is
important
to
further
enhance
therapeutic
benefits
reduce
side
effects.
Here,
an
overview
latest
studies
on
engineering
biomaterials
enhancement
anticancer
immunity
given,
including
perspectives
delivery
immunomodulatory
therapeutics,
cells,
constructing
immune-modulating
scaffolds.
opportunities
challenges
this
field
also
discussed.
Nano-Micro Letters,
Год журнала:
2020,
Номер
12(1)
Опубликована: Июль 5, 2020
Abstract
Although
notable
progress
has
been
made
on
novel
cancer
treatments,
the
overall
survival
rate
and
therapeutic
effects
are
still
unsatisfactory
for
patients.
Chemoimmunotherapy,
combining
chemotherapeutics
immunotherapeutic
drugs,
emerged
as
a
promising
approach
treatment,
with
advantages
of
cooperating
two
kinds
treatment
mechanism,
reducing
dosage
drug
enhancing
effect.
Moreover,
nano-based
delivery
system
(NDDS)
was
applied
to
encapsulate
chemotherapeutic
agents
exhibited
outstanding
properties
such
targeted
delivery,
tumor
microenvironment
response
site-specific
release.
Several
nanocarriers
have
approved
in
clinical
chemotherapy
showed
significant
improvement
efficiency
compared
traditional
formulations,
liposomes
(Doxil
®
,
Lipusu
),
nanoparticles
(Abraxane
)
micelles
(Genexol-PM
).
The
applications
NDDS
chemoimmunotherapy
would
be
powerful
strategy
future
which
could
greatly
enhance
efficacy,
reduce
side
optimize
outcomes
Herein,
current
approaches
immunotherapy
were
discussed,
recent
advances
further
reviewed.
