International Journal of Molecular Sciences,
Год журнала:
2021,
Номер
23(1), С. 22 - 22
Опубликована: Дек. 21, 2021
Within
phototherapy,
a
grand
challenge
in
clinical
cancer
treatments
is
to
develop
simple,
cost-effective,
and
biocompatible
approach
treat
this
disease
using
ultra-low
doses
of
light.
Carbon-based
materials
(CBM),
such
as
graphene
oxide
(GO),
reduced
GO
(r-GO),
quantum
dots
(GQDs),
carbon
(C-DOTs),
are
rapidly
emerging
new
class
therapeutic
against
cancer.
This
review
summarizes
the
progress
made
recent
years
regarding
applications
CBM
photodynamic
(PDT)
photothermal
(PTT)
therapies
for
tumor
destruction.
The
current
understanding
performance
modified
CBM,
hybrids
composites,
also
addressed.
seeks
achieve
an
enhanced
antitumor
action
by
improving
modulating
properties
various
types
Metal
oxides,
organic
molecules,
biopolymers,
drugs,
among
others,
have
been
combined
with
PDT,
PTT,
or
synergistic
therapies.
Chemical Society Reviews,
Год журнала:
2018,
Номер
48(7), С. 2053 - 2108
Опубликована: Сен. 27, 2018
The
nonradiative
conversion
of
light
energy
into
heat
(photothermal
therapy,
PTT)
or
sound
(photoacoustic
imaging,
PAI)
has
been
intensively
investigated
for
the
treatment
and
diagnosis
cancer,
respectively.
By
taking
advantage
nanocarriers,
both
imaging
therapeutic
functions
together
with
enhanced
tumour
accumulation
have
thoroughly
studied
to
improve
pre-clinical
efficiency
PAI
PTT.
In
this
review,
we
first
summarize
development
inorganic
organic
nano
photothermal
transduction
agents
(PTAs)
strategies
improving
PTT
outcomes,
including
applying
appropriate
laser
dosage,
guiding
via
techniques,
developing
PTAs
absorption
in
second
NIR
window,
increasing
(PCE),
also
tumours.
Second,
introduce
advantages
combining
other
therapies
cancer
treatment.
Third,
emerging
applications
cancer-related
research
are
exemplified.
Finally,
perspectives
challenges
combating
especially
regarding
their
clinical
translation,
discussed.
We
believe
that
having
noteworthy
features
would
become
promising
next-generation
non-invasive
theranostic
techniques
our
ability
combat
cancers.
Chemical Society Reviews,
Год журнала:
2017,
Номер
46(15), С. 4400 - 4416
Опубликована: Янв. 1, 2017
Graphene-based
materials
can
contribute
favorably
to
the
biomedical
field.
Particularly
promising
areas
of
development
include
sensors,
controlled
drug
delivery
and
tissue
engineering.
Advanced Materials,
Год журнала:
2019,
Номер
32(13)
Опубликована: Июль 28, 2019
Abstract
2D
nanomaterials
with
unique
nanosheet
structures,
large
surface
areas,
and
extraordinary
physicochemical
properties
have
attracted
tremendous
interest.
In
the
area
of
nanomedicine,
research
on
graphene
its
derivatives
for
diverse
biomedical
applications
began
as
early
2008.
Since
then,
many
other
types
nanomaterials,
including
transition
metal
dichalcogenides,
carbides,
nitrides
carbonitrides,
black
phosphorus
nanosheets,
layered
double
hydroxides,
metal–organic
framework
been
explored
in
nanomedicine
over
past
decade.
particular,
a
makes
highly
efficient
drug
delivery
nanoplatforms.
The
optical
and/or
X‐ray
attenuation
can
be
harnessed
phototherapy
or
radiotherapy
cancer.
Furthermore,
by
integrating
functional
nanoparticles
utilizing
their
inherent
physical
properties,
may
also
engineered
nanoprobes
multimodal
imaging
tumors.
shown
substantial
potential
cancer
theranostics.
Herein,
latest
progress
development
theranostic
is
summarized.
Current
challenges
future
perspectives
applied
are
discussed.
Results in Chemistry,
Год журнала:
2021,
Номер
3, С. 100163 - 100163
Опубликована: Янв. 1, 2021
Since
2004,
graphene
has
attracted
a
lot
of
attention
among
scientists
and
engineers.
In
recent
years,
graphene,
two
dimensional
monolayer
planar
sheet
sp2-bonded
carbon
atom
witnessed
revolution
in
its
applications
because
exemplary
unique
properties
terms
large
specific
surface
area,
physicochemical
properties,
mechanical
strength,
extraordinary
thermal
electronic
conductivity.
There
are
several
techniques
used
to
synthesize
high-quality
on
scale.
This
review
summarizes
the
fabrication
by
chemical,
mechanical,
decomposition
chemical
vapor
deposition.
addition,
characterization
methods
different
research
fields
have
been
discussed.
article
winds
up
giving
brief
summary,
illuminate
problems,
states
prospects
graphene.
Nano-Micro Letters,
Год журнала:
2018,
Номер
10(3)
Опубликована: Май 21, 2018
Graphene-based
nanomaterials
(GBNs)
have
attracted
increasing
interests
of
the
scientific
community
due
to
their
unique
physicochemical
properties
and
applications
in
biotechnology,
biomedicine,
bioengineering,
disease
diagnosis
therapy.
Although
a
large
amount
researches
been
conducted
on
these
novel
nanomaterials,
limited
comprehensive
reviews
are
published
biomedical
potential
environmental
human
health
effects.
The
present
research
aimed
at
addressing
this
knowledge
gap
by
examining
discussing:
(1)
history,
synthesis,
structural
recent
developments
GBNs
for
applications;
(2)
uses
as
therapeutics,
drug/gene
delivery
antibacterial
materials;
(3)
tissue
engineering
biosensors
bioimaging
(4)
effects
risks.
It
also
discussed
perspectives
challenges
associated
with
GBNs.
Photothermal
therapy
(PTT)
is
a
fledgling
therapeutic
strategy
for
cancer
treatment
with
minimal
invasiveness
but
clinical
adoption
has
been
stifled
by
concerns
such
as
insufficient
biodegradability
of
the
PTT
agents
and
lack
an
efficient
delivery
system.
Here,
black
phosphorus
(BP)
nanosheets
are
incorporated
thermosensitive
hydrogel
[poly(d,l-lactide)-poly(ethylene
glycol)-poly(d,l-lactide)
(PDLLA-PEG-PDLLA:
PLEL)]
to
produce
new
system
postoperative
cancer.
The
BP@PLEL
exhibits
excellent
near
infrared
(NIR)
photothermal
performance
rapid
NIR-induced
sol-gel
transition
well
good
biocompatibility
in
vitro
vivo.
Based
on
these
merits,
vivo
established.
Under
NIR
irradiation,
sprayed
enables
gelation
forming
gelled
membrane
wounds
offers
high
efficacy
eliminate
residual
tumor
tissues
after
removal
surgery.
Furthermore,
antibacterial
prevents
infection
this
biodegradable
very
promising
Advanced Healthcare Materials,
Год журнала:
2021,
Номер
10(6)
Опубликована: Янв. 20, 2021
Abstract
It
is
of
great
significance
to
develop
anticancer
therapeutic
agents
or
technologies
with
high
degree
specificity
and
patient
compliance,
while
low
toxicity.
The
emerging
photothermal
therapy
(PTT)
has
become
a
new
powerful
technology
due
its
noninvasiveness,
specificity,
side
effects
normal
tissues
strong
efficacy.
Noble
metal
nanomaterials
possess
surface
plasmon
resonance
(SPR)
effect
synthetic
tunability,
which
make
them
facile
effective
PTT
superior
optical
characteristics,
such
as
absorption
cross‐section,
incomparable
optical‐thermal
conversion
efficiency
in
the
near
infrared
(NIR)
region,
well
potential
bioimaging.
By
incorporating
various
functional
reagents
antibodies,
peptides,
biocompatible
polymers,
chemo‐drug
immune
factors,
noble
have
presented
multifunctional
cancer
therapy.
Herein,
recent
development
regarding
application
for
NIR‐triggered
treatment
summarized.
A
variety
studies
good
against
from
impressive
efficacy
are
concluded.
Intelligent
nanoplatforms
through
ingenious
fabrication
showing
PTT,
combined
chemo‐therapy,
immunotherapy,
photodynamic
(PDT),
simultaneous
imaging
modality
also
demonstrated.
Advanced Materials,
Год журнала:
2018,
Номер
31(9)
Опубликована: Июль 24, 2018
The
extensive
research
of
graphene
and
its
derivatives
in
biomedical
applications
during
the
past
few
years
has
witnessed
significance
field
nanomedicine.
Starting
from
simple
drug
delivery
systems,
application
been
extended
to
a
versatile
platform
multiple
therapeutic
modalities,
including
photothermal
therapy,
photodynamic
magnetic
hyperthermia
sonodynamic
therapy.
In
addition
monotherapy,
graphene-based
materials
are
widely
applied
combined
therapies
for
enhanced
anticancer
activity
reduced
side
effects.
particular,
often
designed
fabricated
as
"smart"
platforms
stimuli-responsive
nanocarriers,
whose
effects
can
be
activated
by
tumor
microenvironment,
such
acidic
pH
elevated
glutathione
(termed
"endogenous
stimuli"),
or
light,
magnetic,
ultrasonic
stimuli
"exogenous
stimuli").
Herein,
recent
advances
smart
therapy
presented,
starting
with
principle
design
applications.
Next,
contributed
materials,
chemotherapy-based,
photothermal-therapy-based,
ultrasound-therapy-based
synergistic
outlined.
addition,
current
challenges
future
prospects
regarding
this
promising
discussed.
