Expert Opinion on Drug Delivery, Год журнала: 2023, Номер 20(11), С. 1553 - 1571
Опубликована: Ноя. 2, 2023
Introduction With the increase in elderly population and prevalence of multiple medical conditions, medication adherence, efficacy have become crucial for effective management their health. The aging faces unique challenges that need to be addressed through advancements drug delivery systems formulation technologies.
Язык: Английский
Journal of Alloys and Compounds, Год журнала: 2020, Номер 846, С. 156471 - 156471
Опубликована: Июль 23, 2020
Язык: Английский
Процитировано
254
European Journal of Pharmaceutical Sciences, Год журнала: 2020, Номер 147, С. 105280 - 105280
Опубликована: Фев. 25, 2020
The release and absorption profile of an oral medication is influenced by the physicochemical properties drug its formulation, as well anatomy physiology gastrointestinal (GI) tract. During development bioavailability a new typically assessed in early clinical studies healthy adult population. However, many disease conditions are associated with alteration and/or GI same holds true for some subpopulations, such paediatric or elderly patients, populations different ethnicity. variation tract compared to adults can directly affect kinetics absorption, thus, safety efficacy medication. This review provides overview special discusses how affected these conditions. Particular focus directed towards non-disease dependent (age, sex, ethnicity, genetic factors, obesity, pregnancy), diseases (ulcerative colitis Crohn's disease, celiac cancer tract, Roux-en-Y gastric bypass, lactose intolerance, Helicobacter pylori infection, infectious tract), systemic that change (cystic fibrosis, diabetes, Parkinson's HIV enteropathy, critical illness). current knowledge about their impact on still limited. Further research required improve confidence pharmacokinetic predictions dosing recommendations targeted patient population, thus ensure safe effective therapies.
Язык: Английский
Процитировано
219
Acta Pharmaceutica Sinica B, Год журнала: 2021, Номер 11(8), С. 2416 - 2448
Опубликована: Апрель 29, 2021
Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules than small molecular drugs due to their high selectivity efficacy, but fewer side effects. Owing the poor stability limited permeability through gastrointestinal (GI) tract epithelia, PPs are usually administered by parenteral route. Given big demand for oral administration in clinical use, a variety of researches focused on developing new technologies overcome GI barriers PPs, such as enteric coating, enzyme inhibitors, permeation enhancers, nanoparticles, well intestinal microdevices. Some been developed under trials even market. This review summarizes history, physiological overcoming approaches, current preclinical technologies, future prospects delivery PPs.
Язык: Английский
Процитировано
213
Advanced Science, Год журнала: 2022, Номер 9(10)
Опубликована: Фев. 3, 2022
Carriers are equally important as drugs. They can substantially improve bioavailability of cargos and safeguard healthy cells from toxic effects certain therapeutics. Recently, polymeric nanocarriers (PNCs) have achieved significant success in delivering drugs not only to but also subcellular organelles. Variety natural sources, availability different synthetic routes, versatile molecular architectures, exploitable physicochemical properties, biocompatibility, biodegradability presented polymers one the most desired materials for nanocarrier design. Recent innovative concepts advances PNC-associated nanotechnology providing unprecedented opportunities engineer their functions. The efficiency therapeutic loading has got considerably increased. Structural design-based varieties PNCs widely employed delivery small molecules genes, proteins. gained ever-increasing attention certainly paves way develop advanced nanomedicines. This article presents a comprehensive investigation structural influences properties on drug profiles with perspectives highlighting inevitability incorporating both multi-stimuli-responsive multi-drug single carrier design intelligent new emerging research directions this rapidly developing area.
Язык: Английский
Процитировано
163
BMJ Open, Год журнала: 2021, Номер 11(9), С. e044987 - e044987
Опубликована: Сен. 1, 2021
This systematic review aimed to describe medication non-adherence among people living with multimorbidity according the current literature, and synthesise predictors of in this population.A was conducted Preferred Reporting Items for Systematic reviews Meta-Analyses. PubMed, EMBASE, CINAHL PsycINFO were searched relevant articles published English language between January 2009 April 2019. Quantitative studies reporting and/or two or more chronic conditions included review. A meta-analysis a subgroup that used an inclusive definition recruit participants, rather than seeking specific conditions. Remaining prevalence narratively synthesised.The database search produced 10 998 records further 75 identified through other sources. Following full-text screening, 178 The range reported differed by measurement method, at 76.5% self-report, 69.4% pharmacy data, 44.1% electronic monitoring. eight (n=8949) participants. pooled 42.6% (95% CI: 34.0 - 51.3%, k=8, I2=97%, p<0.01). overall 7.0%-83.5%. Frequently correlates previous treatment-related beliefs.The heterogeneous literature terms studied, definitions measures used. Results suggest future attempts improve adherence should determine which individuals require most support. variable levels highlight need attention be paid healthcare providers impact on disease self-management.CRD42019133849.
Язык: Английский
Процитировано
121
Advanced Drug Delivery Reviews, Год журнала: 2024, Номер 210, С. 115326 - 115326
Опубликована: Апрель 30, 2024
Transdermal administration remains an active research and development area as alternative route for long-acting drug delivery. It avoids major drawbacks of conventional oral (gastrointestinal side effects, low bioavailability, multiple dosing) or parenteral routes (invasiveness, pain, psychological stress bio-hazardous waste generated from needles), thereby increasing patient appeal compliance. This review focuses on the current state transdermal delivery, including adhesive patches, microneedles, molecularly imprinted polymeric systems. Each subsection describes approach key considerations in formulation development, design, process parameters with schematics. An overview commercially available (adhesive) patches delivery (longer than 24 h), well advanced formulations such core-shell, nanoformulations-incorporated stimuli-responsive 3D-printed polymers is also provided. Finally, we elaborated translational aspects, challenges patch future directions clinical advancement new products
Язык: Английский
Процитировано
18
Journal of Controlled Release, Год журнала: 2025, Номер 380, С. 375 - 395
Опубликована: Фев. 9, 2025
Язык: Английский
Процитировано
2
Advanced Drug Delivery Reviews, Год журнала: 2021, Номер 176, С. 113857 - 113857
Опубликована: Июль 5, 2021
Personalized drug delivery systems (PDDS), implying the patient-tailored dose, dosage form, frequency of administration and release kinetics, digital health platforms for diagnosis treatment monitoring, patient adherence, traceability products, are emerging scientific areas. Both fields advancing at a fast pace. However, despite strong complementary nature these disciplines, there only few successful examples merging Therefore, it is important timely to combine PDDS with an increasing number high-end solutions create interactive feedback loop between actual needs each products. This review provides overview advanced design new products such as personalized that would interconnect pharmaceutical worlds. Furthermore, we discuss recent advancements in supply chain (PSC) management related limitations current mass production model. We summarize state art envision future directions potential development
Язык: Английский
Процитировано
84
Advanced Drug Delivery Reviews, Год журнала: 2022, Номер 186, С. 114293 - 114293
Опубликована: Апрель 26, 2022
Язык: Английский
Процитировано
61
Pharmaceutics, Год журнала: 2022, Номер 14(10), С. 2210 - 2210
Опубликована: Окт. 17, 2022
The rectal route is an effective for the local and systemic delivery of active pharmaceutical ingredients. environment rectum relatively constant with low enzymatic activity favorable drugs having poor oral absorption, extensive first-pass metabolism, gastric irritation, stability issues in environment, localized activity, that cannot be administered by other routes. present review addresses physiology, diseases, factors influencing discusses different drug systems including suppositories, suspensions, microspheres, nanoparticles, liposomes, tablets, hydrogels. Clinical trials on various are presented tabular form. Applications novel carriers viz. solid lipid transferosomes, nano-niosomes, nanomicelles have been discussed demonstrated their potential use administration. Various opportunities challenges recent advancements patented formulations also included.
Язык: Английский
Процитировано
56