Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

Journal of Hematology & Oncology, Год журнала: 2022, Номер 15(1)

Опубликована: Сен. 12, 2022

Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one the obstacles in cancer therapy. To help overcome this, nanoscale drug delivery systems have provided an alternative avenue for improving therapeutic potential various agents and bioactive molecules through enhanced permeability retention (EPR) effect. Nanosystems with cancer-targeted ligands can achieve effective tumor cells utilizing cell surface-specific receptors, vasculature antigens high accuracy affinity. Additionally, stimuli-responsive nanoplatforms also been as a promising strategy against tumors, these maintain their stealth feature under conditions, but upon homing cancerous lesions or microenvironment, are responsive release cargoes. In this review, we comprehensively summarize field active number studies context emerging nanoplatform development, discuss how knowledge contribute further improvements clinical practice.

Язык: Английский

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Polymeric Nanoparticles for Drug Delivery

Chemical Reviews, Год журнала: 2024, Номер 124(9), С. 5505 - 5616

Опубликована: Апрель 16, 2024

The recent emergence of nanomedicine has revolutionized the therapeutic landscape and necessitated creation more sophisticated drug delivery systems. Polymeric nanoparticles sit at forefront numerous promising designs, due to their unmatched control over physiochemical properties such as size, shape, architecture, charge, surface functionality. Furthermore, polymeric have ability navigate various biological barriers precisely target specific sites within body, encapsulate a diverse range cargo efficiently release this in response internal external stimuli. However, despite these remarkable advantages, presence wider clinical application is minimal. This review will provide comprehensive understanding vehicles. affecting be outlined first, followed by description nanoparticle designs preparation methods, beginning with polymers on which they are based. meticulously explore current performance against myriad diseases including cancer, viral bacterial infections, before finally evaluating advantages crucial challenges that determine potential decades come.

Язык: Английский

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Structure‐Based Varieties of Polymeric Nanocarriers and Influences of Their Physicochemical Properties on Drug Delivery Profiles

Advanced Science, Год журнала: 2022, Номер 9(10)

Опубликована: Фев. 3, 2022

Carriers are equally important as drugs. They can substantially improve bioavailability of cargos and safeguard healthy cells from toxic effects certain therapeutics. Recently, polymeric nanocarriers (PNCs) have achieved significant success in delivering drugs not only to but also subcellular organelles. Variety natural sources, availability different synthetic routes, versatile molecular architectures, exploitable physicochemical properties, biocompatibility, biodegradability presented polymers one the most desired materials for nanocarrier design. Recent innovative concepts advances PNC-associated nanotechnology providing unprecedented opportunities engineer their functions. The efficiency therapeutic loading has got considerably increased. Structural design-based varieties PNCs widely employed delivery small molecules genes, proteins. gained ever-increasing attention certainly paves way develop advanced nanomedicines. This article presents a comprehensive investigation structural influences properties on drug profiles with perspectives highlighting inevitability incorporating both multi-stimuli-responsive multi-drug single carrier design intelligent new emerging research directions this rapidly developing area.

Язык: Английский

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Polymer- and lipid-based nanocarriers for ocular drug delivery: Current status and future perspectives

Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 196, С. 114770 - 114770

Опубликована: Март 7, 2023

Ocular diseases seriously affect patients' vision and life quality, with a global morbidity of over 43 million blindness. However, efficient drug delivery to treat ocular diseases, particularly intraocular disorders, remains huge challenge due multiple barriers that significantly the ultimate therapeutic efficacy drugs. Recent advances in nanocarrier technology offer promising opportunity overcome these by providing enhanced penetration, increased retention, improved solubility, reduced toxicity, prolonged release, targeted loaded eyes. This review primarily provides an overview progress contemporary applications nanocarriers, mainly polymer- lipid-based treating various eye highlighting their value achieving delivery. Additionally, covers administration routes, as well prospective future developments challenges field nanocarriers for diseases.

Язык: Английский

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Stimuli-Responsive Polymer-Based Nanosystems for Cancer Theranostics

ACS Nano, Год журнала: 2023, Номер 17(23), С. 23223 - 23261

Опубликована: Дек. 2, 2023

Stimuli-responsive polymers can respond to internal stimuli, such as reactive oxygen species (ROS), glutathione (GSH), and pH, biological enzymes, external lasers ultrasound, etc., by changing their hydrophobicity/hydrophilicity, degradability, ionizability, thus have been widely used in biomedical applications. Due the characteristics of tumor microenvironment (TME), stimuli-responsive that cater specifically TME extensively prepare smart nanovehicles for targeted delivery therapeutic diagnostic agents tissues. Compared conventional drug nanosystems, TME-responsive nanosystems many advantages, high sensitivity, broad applicability among different tumors, functional versatility, improved biosafety. In recent years, a great deal research has devoted engineering efficient polymeric significant improvement made both cancer diagnosis therapy. this review, we summarize some advances involving use polymer nanocarriers delivery, imaging, therapy, theranostics. Various chemical stimuli will be described context nanosystems. Accordingly, groups responsible responsiveness strategies incorporate these into discussed detail. With on topic expending at fast pace, innovative concepts, sequential cascade release, NIR-II multifunctional formulations, emerged popular enhanced performance, which also included here with up-to-date illustrations. We hope review offer valuable insights selection optimization help accelerate future applications treatment.

Язык: Английский

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Recent advances in biopolymer-based hydrogels and their potential biomedical applications

Carbohydrate Polymers, Год журнала: 2023, Номер 323, С. 121408 - 121408

Опубликована: Сен. 17, 2023

Язык: Английский

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Multi-functional chitosan-based nanoparticles for drug delivery: Recent advanced insight into cancer therapy

Carbohydrate Polymers, Год журнала: 2023, Номер 315, С. 120972 - 120972

Опубликована: Май 6, 2023

Язык: Английский

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Recent advances in the design of controlled- and sustained-release micro/nanocarriers of pesticide

Environmental Science Nano, Год журнала: 2023, Номер 10(2), С. 351 - 371

Опубликована: Янв. 1, 2023

Diagram of components controlled- and sustained-release micro/nanocarriers pesticide: nanomaterials stimuli-responsive triggers (R stands for different groups).

Язык: Английский

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Recent Applications of PLGA in Drug Delivery Systems

Polymers, Год журнала: 2024, Номер 16(18), С. 2606 - 2606

Опубликована: Сен. 14, 2024

Poly(lactic-co-glycolic acid) (PLGA) is a widely used biodegradable and biocompatible copolymer in drug delivery systems (DDSs). In this article, we highlight the critical physicochemical properties of PLGA, including its molecular weight, intrinsic viscosity, monomer ratio, blockiness, end caps, that significantly influence release profiles degradation times. This review also covers extensive literature on application PLGA delivering small-molecule drugs, proteins, peptides, antibiotics, antiviral drugs. Furthermore, discuss role PLGA-based DDSs treating various diseases, cancer, neurological disorders, pain, inflammation. The incorporation drugs into nanoparticles microspheres has been shown to enhance their therapeutic efficacy, reduce toxicity, improve patient compliance. Overall, holds great promise for advancement treatment management multiple chronic conditions.

Язык: Английский

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Self‐Assembled Nanocarrier Delivery Systems for Bioactive Compounds

Small, Год журнала: 2024, Номер 20(26)

Опубликована: Янв. 12, 2024

Abstract Although bioactive compounds (BCs) have many important functions, their applications are greatly limited due to own defects. The development of nanocarriers (NCs) technology has gradually overcome the defects BCs. NCs equally as BCs some extent. Self‐assembly (SA) methods build advantages than chemical methods, and SA significant impact on structure function NCs. However, relationship among mechanism, structure, not been given enough attention. Therefore, from perspective bottom‐up building concept SA‐structure‐function is emphasized promote SA‐based First, conditions forces for occurring introduced, then basis molecular mechanism protein, polysaccharide, lipid summarized. Then, varieties structures formed based introduced in detail. Finally, facing how be well solved by also elaborated. This review attempts describe great significance constructing artificial deliver aspects SA‐structure‐function, so wide application

Язык: Английский

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