Neurotropic Effects of Cortexin on Models of Mental and Physical Developmental Delay DOI Creative Commons
Д. В. Куркин, Д. А. Бакулин, Е. И. Морковин

и другие.

Biomedicines, Год журнала: 2025, Номер 13(4), С. 860 - 860

Опубликована: Апрель 2, 2025

Objective: To evaluate the efficacy of neurotropic action cortexin in models mental and physical developmental delays rat offspring. Methods: The properties bovine brain cortex polypeptides were studied using two rats: toxic CNS damage (oral administration ethanol during last week pregnancy) neonatal trauma (ischemia-hypoxia). drug was administered intramuscularly or rectally as suppositories for 20 days. Treatment evaluated mNSS scale, open field, rotarod, adhesive removal tests. A histological examination subsequently performed. In a separate series experiments mice, concentration test reference cerebrolysin determined blood tissue samples radioactive iodine (Na125I) labeling these preparations. Results: Modeling delay offspring (due to effect late pregnancy trauma) led pronounced neurological deficits, manifested by decreased motor activity, sensorimotor, coordination disorders. Administration all forms reduced severity deficits measured scores, improved activity Open Field test, enhanced performance Adhesive Removal Rotarod tests, structural changes tissues. Histological revealed neuronal multiple cortical regions, with significant increase normal, unchanged neurons compared placebo groups. Comparison concentrations labeled Na125I depending on type showed similar distribution profiles tissues, primarily dependent its concentration, which influenced route administration. Conclusions: results indicate that (cortexin), either rectally, can reach systemic circulation cross blood-brain barrier, demonstrated our studies radiolabeled These exert comparable effects caused rats.

Язык: Английский

Biomedical applications of functional hydrogels: Innovative developments, relevant clinical trials and advanced products DOI Creative Commons

Katrin Zöller,

Dennis To,

Andreas Bernkop‐Schnürch

и другие.

Biomaterials, Год журнала: 2024, Номер 312, С. 122718 - 122718

Опубликована: Июль 27, 2024

Functional hydrogels are used for numerous biomedical applications such as tissue engineering, wound dressings, lubricants, contact lenses and advanced drug delivery systems. Most of them based on synthetic or natural polymers forming a three-dimensional network that contains aqueous media. Among polymers, poly(meth)acrylates, polyethyleneglycols, poly(vinylalcohols), poly(vinylpyrrolidones), PLGA poly(urethanes) high relevance, whereas mainly polysaccharides hyaluronic acid, alginate chitosan proteins albumin, collagen elastin. In contrast to most biodegradable. Both often chemically modified in order improve induce favorable properties functions like mechanical strength, stiffness, elasticity, porosity, adhesive properties, situ gelling water binding capacity release controlling properties. Within this review we provide an overview about the broad spectrum functional hydrogels, summarize innovative approaches, discuss concept relevant clinical trials highlight products examples successful developments.

Язык: Английский

Процитировано

48
Review of Gold Nanoparticles: Synthesis, Properties, Shapes, Cellular Uptake, Targeting, Release Mechanisms and Applications in Drug Delivery and Therapy DOI Creative Commons

Joel Georgeous,

Nour AlSawaftah, Waad H. Abuwatfa

и другие.

Pharmaceutics, Год журнала: 2024, Номер 16(10), С. 1332 - 1332

Опубликована: Окт. 16, 2024

The remarkable versatility of gold nanoparticles (AuNPs) makes them innovative agents across various fields, including drug delivery, biosensing, catalysis, bioimaging, and vaccine development. This paper provides a detailed review the important role AuNPs in delivery therapeutics. We begin by exploring traditional systems (DDS), highlighting revolutionizing techniques. then describe unique intriguing properties that make exceptional for delivery. Their shapes, functionalization, drug-loading bonds, targeting mechanisms, release therapeutic effects, cellular uptake methods are discussed, along with relevant examples from literature. Lastly, we present applications medical domains, cancer, cardiovascular diseases, ocular diabetes, focus on vitro vivo cancer research.

Язык: Английский

Процитировано

24
Recent approaches in nanotoxicity assessment for drug delivery applications: Challenges and prospects DOI Creative Commons
J. B. Thomas, Vinay Kumar, Neha Sharma

и другие.

Medicine in Drug Discovery, Год журнала: 2025, Номер unknown, С. 100204 - 100204

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

3
Preparation of mucoadhesive methacrylated chitosan nanoparticles for delivery of ciprofloxacin DOI

Renas Rzgar Jalal,

Twana Mohammed M. Ways,

Mahmoud H. Abu Elella

и другие.

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 242, С. 124980 - 124980

Опубликована: Май 25, 2023

Язык: Английский

Процитировано

41
Pullulan hydrogels as drug release platforms in biomedicine DOI Creative Commons
Marta O. Teixeira, Elina Marinho, Carla Silva

и другие.

Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 89, С. 105066 - 105066

Опубликована: Окт. 18, 2023

It is increasingly urgent to develop new therapeutic systems combat the spreading and evolution of various pathologies globally. Nonspecific therapies and/or insufficient medication biodistribution might hinder patient's recovery. In this sense, a targeted controlled delivery biomolecules allows overcoming limitations conventional systems, taking user one step closer successful treatment disease. Hydrogels have been highlighted for their drug abilities, particularly tunable properties, like hydration capacity, biodegradability, release kinetics, etc., that can be adjusted desired needs. Additionally, they produced from either natural synthetic polymers, with natural-origin sources providing exceptional features biodegradation acceptable integration in biological systems. One those polymers pullulan, biodegradable, biocompatible hemocompatible material, multiple uses biomedicine. Investigations into pullulan-based hydrogels progressively increased over last few decades. This review addresses pullulan biomedical engineering, emphasizing its properties processing hydrogel original or derivative forms.

Язык: Английский

Процитировано

24
Biomedical Trends in Stimuli-Responsive Hydrogels with Emphasis on Chitosan-Based Formulations DOI Creative Commons
Weronika Kruczkowska, Julia Gałęziewska,

Katarzyna Grabowska

и другие.

Gels, Год журнала: 2024, Номер 10(5), С. 295 - 295

Опубликована: Апрель 25, 2024

Biomedicine is constantly evolving to ensure a significant and positive impact on healthcare, which has resulted in innovative distinct requisites such as hydrogels. Chitosan-based formulations stand out for their versatile utilization drug encapsulation, transport, controlled release, complemented by biocompatibility, biodegradability, non-immunogenic nature. Stimuli-responsive hydrogels, also known smart have strictly regulated release patterns since they respond adapt based various external stimuli. Moreover, can imitate the intrinsic tissues’ mechanical, biological, physicochemical properties. These characteristics allow stimuli-responsive hydrogels provide cutting-edge, effective, safe treatment. Constant progress field necessitates an up-to-date summary of current trends breakthroughs biomedical application chitosan-based was aim this review. General data about sensitive ions, pH, redox potential, light, electric field, temperature, magnetic are recapitulated. Additionally, responsive multiple stimuli mentioned. Focusing multifaceted thoroughly described. The vast spectrum encompasses neurological disorders, tumors, wound healing, dermal infections. Available chitosan strongly support idea that approaches developing novel solutions worth improving. present paper constitutes valuable resource researchers practitioners currently field.

Язык: Английский

Процитировано

11
Advancements in hydrogel-based drug delivery systems for the treatment of inflammatory bowel disease: a review DOI
Ye Liu, Jinjian Huang, Sicheng Li

и другие.

Biomaterials Science, Год журнала: 2023, Номер 12(4), С. 837 - 862

Опубликована: Дек. 22, 2023

Inflammatory bowel disease (IBD) is a chronic disorder that affects millions of individuals worldwide. However, current drug therapies for IBD are plagued by significant side effects, low efficacy, and poor patient compliance. Consequently, there an urgent need novel therapeutic approaches to alleviate IBD. Hydrogels, three-dimensional networks hydrophilic polymers with the ability swell retain water, have emerged as promising materials delivery in treatment due their biocompatibility, tunability, responsiveness various stimuli. In this review, we summarize recent advancements hydrogel-based systems We first identify three pathophysiological alterations be addressed IBD: damage intestinal mucosal barrier, dysbiosis flora, activation inflammatory signaling pathways leading disequilibrium within intestines. Subsequently, discuss depth processes required prepare hydrogel systems, from selection materials, types drugs loaded, methods loading release mechanisms key points preparation systems. Additionally, highlight progress impact system through regulation physical barrier immune responses, promotion repair, improvement gut microbiota. conclusion, analyze challenges clinical applications treatment, propose potential solutions our perspective.

Язык: Английский

Процитировано

22
A Comprehensive review on Pharmacokinetic Studies of Vaccines: Impact of delivery route, carrier-and its modulation on immune response DOI
Saurav Kumar Jha, Mohammad Imran, Laxmi Akhileshwar Jha

и другие.

Environmental Research, Год журнала: 2023, Номер 236, С. 116823 - 116823

Опубликована: Авг. 3, 2023

Язык: Английский

Процитировано

21
Efficient oral delivery of resveratrol-loaded cyclodextrin-metal organic framework for alleviation of ulcerative colitis DOI
Tao Chen, Lihang Chen,

Fengxian Luo

и другие.

International Journal of Pharmaceutics, Год журнала: 2023, Номер 646, С. 123496 - 123496

Опубликована: Окт. 6, 2023

Язык: Английский

Процитировано

19
3D-printed Laponite/Alginate hydrogel-based suppositories for versatile drug loading and release DOI Creative Commons

Elena Munoz-Perez,

Jorge Rubio‐Retama, Lorena Cussó

и другие.

Drug Delivery and Translational Research, Год журнала: 2024, Номер 14(12), С. 3385 - 3403

Опубликована: Янв. 7, 2024

Traditional approaches to solid rectal therapies have halted progress, leading a continual decline in the use of conventional suppositories. Additive manufacturing techniques been recently explored as suitable innovative tool for suppository fabrication. However, little advancement has made composition materials 3D-printed (3DPS) and still, vehicles are often used construct fabrication, hindering growth field. As novelty, this study unveils ground-breaking Laponite-alginate hydrogel-based 3DPS. Interestingly, proposes novel approach loading drugs into 3DPS employing first time post-printing loading. Thus, passive strategy molecular models is developed, demonstrating versatility capacity load molecules different charges sizes within matrix systems. This allows adapting wide range single ink, which simplifies speeds up technological development process with physico-chemical properties. Additionally, research, displacement three-dimensional Laponite matrices developed order enhance drug release through their disintegration capacity, resulting significant improvement diffusion hydrogel rapid Finally, our demonstrates that obtained vivo behavior, being non-obstructive allowing normal motility rats intestine.

Язык: Английский

Процитировано

7