Corticosteroids in oncology: Use, overuse, indications, contraindications. An Italian Association of Medical Oncology (AIOM)/ Italian Association of Medical Diabetologists (AMD)/ Italian Society of Endocrinology (SIE)/ Italian Society of Pharmacology (SIF) multidisciplinary consensus position paper

Critical Reviews in Oncology/Hematology, Год журнала: 2022, Номер 180, С. 103826 - 103826

Опубликована: Сен. 30, 2022

Corticosteroids (CSs) are widely used in oncology, presenting several different indications. They useful for induction of apoptosis hematological neoplasms, management anaphylaxis and cytokine release/hypersensitivity reaction the symptomatic treatment many tumour- treatment-related complications. If employment CSs oncological setting results benefits patients satisfaction clinicians, on other hand, potential adverse events (AEs), both during after withdrawal CSs, as well duality effects these compounds recommend being cautious clinical practice. To date, gray zones remain about indications, contraindications, dose, duration treatment. In this article, a panel experts provides critical review therapy focusing mechanisms action pharmacological characteristics, current emerging therapeutic indications/contraindications, AEs related to treatment, impact patient outcome.

Язык: Английский

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Circadian rhythm in systemic autoimmune conditions: Potential of chrono-immunology in clinical practice: A narrative review

Medicine, Год журнала: 2023, Номер 102(32), С. e34614 - e34614

Опубликована: Авг. 11, 2023

The circadian rhythm (CR) is a fundamental biological process regulated by the Earth’s rotation and solar cycles. It plays critical role in various bodily functions, its dysregulation can have systemic effects. These effects impact metabolism, redox homeostasis, cell cycle regulation, gut microbiota, cognition, immune response. Immune mediators, proteins, hormones exhibit oscillations, supporting optimal function defence against pathogens. Sleep deprivation disruptions challenge regulatory mechanisms, making responses vulnerable. Altered CR pathways been implicated diseases such as diabetes, neurological conditions, autoimmune (SADs). SADs involve abnormal to self-antigens, with genetic environmental factors disrupting self-tolerance contributing conditions like Systemic Lupus Erythematosus, Rheumatoid Arthritis, Inflammatory Myositis. Dysregulated may lead increased production of pro-inflammatory cytokines, observed SADs. disturbances significantly quality life patients SADs; however, they are often overlooked. relationship between sleep whether causal or consequential dysregulation, remains unclear. Chrono-immunology investigates immunity, offering potential for targeted therapies conditions. This paper provides an overview connections highlighting importance recognizing need further research into complex diseases.

Язык: Английский

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Diet’s Impact on Post-Traumatic Brain Injury Depression: Exploring Neurodegeneration, Chronic Blood–Brain Barrier Destruction, and Glutamate Neurotoxicity Mechanisms

Nutrients, Год журнала: 2023, Номер 15(21), С. 4681 - 4681

Опубликована: Ноя. 4, 2023

Traumatic brain injury (TBI) has a profound impact on cognitive and mental functioning, leading to lifelong impairment significantly diminishing the quality of life for affected individuals. A healthy blood-brain barrier (BBB) plays crucial role in guarding against elevated levels blood glutamate, making its permeability vital aspect glutamate regulation within brain. Studies have shown efficacy reducing excess as treatment post-TBI depression, anxiety, aggression. The purpose this article is evaluate involvement dietary development depression after TBI. We performed literature search examine effects diets abundant which are common Asian populations, when compared low prevalent Europe America. specifically explored these context chronic BBB damage TBI, may initiate neurodegeneration subsequently an through mechanism neurotoxicity. glutamate-rich diet leads increased contrasted with glutamate-poor diet. Within disruption, translate heightened concentrations, thereby intensifying due

Язык: Английский

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Targeting glucocorticoid receptor signaling pathway for treatment of stress-related brain disorders

Pharmacological Reports, Год журнала: 2024, Номер unknown

Опубликована: Окт. 3, 2024

Язык: Английский

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<p>Dexamethasone-Loaded Thermosensitive Hydrogel Suppresses Inflammation and Pain in Collagen-Induced Arthritis Rats</p>

Drug Design Development and Therapy, Год журнала: 2020, Номер Volume 14, С. 4101 - 4113

Опубликована: Окт. 1, 2020

To overcome negative adverse effects and improve therapeutic index of dexamethasone (Dex) in rheumatoid arthritis (RA), we developed a novel sustained release formulation-intra-articular injectable dexamethasone-loaded thermosensitive hydrogel (DLTH) with chitosan-glycerin-borax as carrier for the remission inflammation pain. The focus this article is to explore both anti-inflammatory pain-relieving DLTH joint injection bovine type-II collagen-induced (CIA) rats.Wistar rats were randomized into three groups, including normal group (n=6), model (n=6) (n=10). Joint (1mg/kg Dex per rat) was injected on day 12 twice week weeks. Clinical signs body weight, paw swelling scores, histologic analysis, hind mechanical withdrawal threshold (MWT), plantar pressure pain (PPT) taken consideration. Serum contents IL-17A, prostaglandin E2 (PGE2), prostacyclin 2 (PGI2) D2 (PGD2), real-time polymerase chain reaction (PCR) analysis inflammatory factors pain-related mediators synovium dorsal root ganglia (DRG), Western blotting NF-κB all evaluated.Paw swelling, scores destruction attenuated DLTH-treated group. Results showed that not only down-regulated serum but also mRNA levels NGF, key proteins pathway synovium. Increases MWT PPT elucidated pain-reducing DLTH. Elevated PGD2 declines PGE2 PGI2, genes DRGs recorded.These data impeded synovial processes through down-regulating transcription activity pathway, intra-articular may aid regulation RA regulating conduction process.

Язык: Английский

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