Diet’s Impact on Post-Traumatic Brain Injury Depression: Exploring Neurodegeneration, Chronic Blood–Brain Barrier Destruction, and Glutamate Neurotoxicity Mechanisms

Nutrients, Journal Year: 2023, Volume and Issue: 15(21), P. 4681 - 4681

Published: Nov. 4, 2023

Traumatic brain injury (TBI) has a profound impact on cognitive and mental functioning, leading to lifelong impairment significantly diminishing the quality of life for affected individuals. A healthy blood-brain barrier (BBB) plays crucial role in guarding against elevated levels blood glutamate, making its permeability vital aspect glutamate regulation within brain. Studies have shown efficacy reducing excess as treatment post-TBI depression, anxiety, aggression. The purpose this article is evaluate involvement dietary development depression after TBI. We performed literature search examine effects diets abundant which are common Asian populations, when compared low prevalent Europe America. specifically explored these context chronic BBB damage TBI, may initiate neurodegeneration subsequently an through mechanism neurotoxicity. glutamate-rich diet leads increased contrasted with glutamate-poor diet. Within disruption, translate heightened concentrations, thereby intensifying due

Language: Английский

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Construction of a thermosensitive gel based on hydroxypropyl-β-cyclodextrin/meloxicam inclusion complexes for improving meloxicam solubility and prolonging drug retention time in the cornea

Drug Delivery and Translational Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Language: Английский

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Glucocorticoid pre-administration improves LNP-mRNA mediated protein replacement and genome editing therapies

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125282 - 125282

Published: Jan. 1, 2025

Language: Английский

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Unveiling the novel role of circadian rhythms in sepsis and septic shock: unexplored implications for chronotherapy

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 4, 2025

Circadian rhythms are critical to coordinating body processes external environmental cues, such as light and feeding, ensure efficiency maintain optimal health. These controlled by ‘clock’ transcription factors, Clock, Bmal1, Per1/2, Cry1/2, Rev-erbs, which present in almost every tissue. In modern society, disruptions normal circadian increasingly prevalent due extended lighting, shift work, long-distance travel. misalign cues contribute diseases obesity non-alcoholic fatty liver disease. They also exacerbate pre-existing health issues, depression inflammatory bowel The response acute infection displays remarkable rhythmicity humans with increased activity during the night or rest period. Severe bloodborne infections, exemplified sepsis progression septic shock, can not only disrupt of but be exacerbated misalignment. Examples shock include alteration loss hormonal controlling blood pressure inflammation, white cell counts, cytokine secretions. changes hinder recovery increase mortality. Chronotherapy chronopharmacotherapy promising approaches resynchronise leverage optimise medication efficacy, respectively, hold much potential treatment shock. Despite knowledge how change these grave conditions, very little research has been undertaken on use therapies support management. This review details associated influence they have morbidity mortality, clinical benefits circadian-modulating therapies.

Language: Английский

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Drugs and Interaction Attributes

Published: Jan. 1, 2025

Language: Английский

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