Intelligent biobased hydrogels for diabetic wound healing: A review

Chemical Engineering Journal, Год журнала: 2024, Номер 484, С. 149493 - 149493

Опубликована: Фев. 10, 2024

Язык: Английский

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Multi-Functional hydrogels to promote diabetic wound Healing: A review

Chemical Engineering Journal, Год журнала: 2024, Номер 497, С. 154855 - 154855

Опубликована: Авг. 14, 2024

Язык: Английский

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Enhanced Mechanical Strength and Sustained Drug Release in Carrier‐Free Silver‐Coordinated Anthraquinone Natural Antibacterial Anti‐Inflammatory Hydrogel for Infectious Wound Healing

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Май 10, 2024

The persistent challenge of healing infectious wounds and the rise bacterial resistance represent significant hurdles in contemporary medicine. In this study, based on natural small molecule drug Rhein self-assembly to form hydrogels coordinate assembly with silver ions (Ag

Язык: Английский

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Hydroxypropyl chitosan/ε-poly-l-lysine based injectable and self-healing hydrogels with antimicrobial and hemostatic activity for wound repair

Carbohydrate Polymers, Год журнала: 2024, Номер 337, С. 122135 - 122135

Опубликована: Апрель 7, 2024

Язык: Английский

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Advancements in Wound Dressing Materials: Highlighting Recent Progress in Hydrogels, Foams, and Antimicrobial Dressings

Gels, Год журнала: 2025, Номер 11(2), С. 123 - 123

Опубликована: Фев. 7, 2025

Recent advancements in wound dressing materials have significantly improved acute and chronic management by addressing challenges such as infection control, moisture balance, enhanced healing. Important progress has been made, especially with hydrogels, foams, antimicrobial for creating optimized dressings. Hydrogels are known maintaining optimal levels, while foam dressings excellent exudate absorbents. Meanwhile, incorporates various agents to reduce risks. These options healing time focusing on customized patient needs. Therefore, this review highlights the newest research prototypes applications, emphasizing their particular benefits clinical importance. Innovations stimuli-responsive hydrogels hybrid bioengineered composites discussed relation properties, including responsiveness pH, temperature, glucose, or enzymes drug delivery precision. Moreover, ongoing trials included, demonstrating potential of emerging solutions be soon translated from laboratory settings. By discussing interdisciplinary approaches that integrate advanced materials, nanotechnology, biological insights, work provides a contemporary framework patient-centric, efficient care strategies.

Язык: Английский

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Exploring advancements in polysaccharide-based approaches: The cornerstone of next-generation cartilage regeneration therapeutics

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141352 - 141352

Опубликована: Фев. 1, 2025

Язык: Английский

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Resveratrol-Ampicillin Dual-Drug Loaded Polyvinylpyrrolidone/Polyvinyl Alcohol Biomimic Electrospun Nanofiber Enriched with Collagen for Efficient Burn Wound Repair

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 5397 - 5418

Опубликована: Июнь 1, 2024

Background: The healing of burn wounds is a complicated physiological process that involves several stages, including haemostasis, inflammation, proliferation, and remodelling to rebuild the skin subcutaneous tissue integrity. Recent advancements in nanomaterials, especially nanofibers, have opened new way for efficient due burning or other injuries. Methods: This study aims develop characterize collagen-decorated, bilayered electrospun nanofibrous mats composed PVP PVA loaded with Resveratrol (RSV) Ampicillin (AMP) accelerate wound repair. Results: Nanofibers smooth surfaces web-like structures diameters ranging from 200 400 nm were successfully produced by electrospinning. These fibres exhibited excellent vitro properties, ability absorb exudates undergo biodegradation over two-week period. Additionally, these nanofibers demonstrated sustained controlled release encapsulated through studies. zone inhibition (ZOI) PVP-PVA-RSV-AMP against Staphylococcus aureus ( S. aureus) Escherichia coli E. ) was found 31± 0.09 mm 12± 0.03, respectively, which significantly higher as compared positive control. Similarly, biofilm confirmed significant reduction formation biofilms nanofiber-treated group both . X-ray diffraction (XRD) Fourier transform infrared spectroscopy (FTIR) analysis proved encapsulation RSV AMP into their compatibility. Haemolysis assay (%) showed no haemolysis (less than 5%) groups, cytocompatibility red blood cells (RBCs). Cell viability cell adhesion on HaCaT increased indicating its biocompatibility well non-toxic properties. Results in-vivo experiments model potential rats H&E-stained images also improved collagen synthesis nanofibers-treated groups evidenced Masson-trichrome staining. ELISA clearly indicated downregulation TNF-alpha IL-6 inflammatory biomarkers after treatment day 10. Conclusion: AMP-loaded nanofiber mats, developed this study, expedite multifaceted approach. Keywords: electrospinning, nanofiber, resveratrol, ampicillin, healing,

Язык: Английский

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Polysaccharide- and protein-based hydrogel dressings that enhance wound healing: A review

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 135482 - 135482

Опубликована: Сен. 1, 2024

Язык: Английский

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Polymer-Based Functional Materials Loaded with Metal-Based Nanoparticles as Potential Scaffolds for the Management of Infected Wounds

Pharmaceutics, Год журнала: 2024, Номер 16(2), С. 155 - 155

Опубликована: Янв. 23, 2024

Wound infection due to bacterial invasion at the wound site is one of primary challenges associated with delayed healing. Microorganisms tend form biofilms that protect them from harm, leading their multidrug resistance. The alarming increase in antibiotic resistance poses a threat Hence, urgent need for novel dressing materials capable managing crucial expediting recovery. There considerable interest polymeric dressings embedded bioactive substances, such as metal-based nanoparticles, potential solutions treating microbially infected wounds. Metal-based nanoparticles have been widely used management wounds broad antimicrobial efficacy. This review focuses on polymer-based and loaded like silver, gold, magnesium oxide, or zinc oxide. When compared, oxide-loaded exhibited higher antibacterial activity against Gram-positive strains silver nanoparticle-loaded gram-negative strains. However, infused both displayed synergistic effect bacteria. Furthermore, these antibiofilm generation reactive oxygen species while accelerating closure vitro vivo.

Язык: Английский

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NIR-responsive electrospun nanofiber dressing promotes diabetic-infected wound healing with programmed combined temperature-coordinated photothermal therapy

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Июль 1, 2024

Abstract Background Diabetic wounds present significant challenges, specifically in terms of bacterial infection and delayed healing. Therefore, it is crucial to address local issues promote accelerated wound In this investigation, we utilized electrospinning fabricate microgel/nanofiber membranes encapsulating MXene-encapsulated microgels chitosan/gelatin polymers. Results The film dressing facilitates programmed photothermal therapy (PPT) mild (MPTT) under near-infrared (NIR), showcasing swift extensive antibacterial biofilm-disrupting capabilities. PPT effect achieves prompt sterilization within 5 min at 52 °C disperses mature biofilm 10 min. Concurrently, by adjusting the NIR power induce heating (42 °C), stimulates fibroblast proliferation migration, significantly enhancing vascularization. Moreover, vivo experimentation successfully validates dressing, underscoring its immense potential addressing intricacies diabetic wounds. Conclusions MXene microgel-loaded nanofiber employs temperature-coordinated therapy, effectively amalgamating advantageous features high-temperature low-temperature promotion It exhibits rapid, broad-spectrum capabilities, exceptional biocompatibility, noteworthy effects on promoting cell These results affirm efficacy our highlighting challenge struggling heal due infection. Graphical

Язык: Английский

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