Immunogenicity, safety, usability and acceptability of microarray patches for vaccination: a systematic review and meta-analysis DOI Creative Commons
Matthew N. Berger, Ellen S Mowbray, Marian W A Farag

и другие.

BMJ Global Health, Год журнала: 2023, Номер 8(10), С. e012247 - e012247

Опубликована: Окт. 1, 2023

Background Microarray patches (MAPs) deliver vaccines to the epidermis and upper dermis, where abundant immune cells reside. There are several potential benefits using MAPs, including reduced sharps risk, thermostability, no need for reconstitution, tolerability self-administration. We aimed explore evaluate immunogenicity, safety, usability acceptability of MAPs vaccination. Methods searched CINAHL, Cochrane Library, Ovid Embase, MEDLINE Web Science from inception January 2023. Eligibility criteria included all research studies in any language, which examined microarrays or microneedles intended used vaccination explored their findings. Two reviewers conducted title abstract screening, full-text reviewing data extraction. Results Twenty-two were (quantitative=15, qualitative=2 mixed methods=5). The risk bias was mostly low, with two at high bias. Four clinical trials included, three influenza antigens one Japanese encephalitis delivered by MAP. A meta-analysis indicated similar higher immunogenicity compared needle syringe (N&S) (standardised mean difference=10.80, 95% CI: 3.51 18.08, p<0.00001). significant differences cell function between N&S. No serious adverse events reported MAPs. Erythema more common after MAP application than N&S but brief well tolerated. Lower pain scores usually Most found easy use highly acceptable among healthcare professionals, laypeople parents. Conclusion safe tolerated evoked enhanced N&S, further is needed. Vaccine uptake may be increased due less pain, layperson could benefit at-risk groups low middle-income countries. PROSPERO registration number CRD42022323026.

Язык: Английский

Microneedle-Mediated Vaccination: Innovation and Translation DOI
Tao Sheng, Bowen Luo, Wentao Zhang

и другие.

Advanced Drug Delivery Reviews, Год журнала: 2021, Номер 179, С. 113919 - 113919

Опубликована: Авг. 8, 2021

Язык: Английский

Процитировано

118
Jet injectors: Perspectives for small volume delivery with lasers DOI Creative Commons
Jelle J. Schoppink, David Fernández Rivas

Advanced Drug Delivery Reviews, Год журнала: 2022, Номер 182, С. 114109 - 114109

Опубликована: Янв. 6, 2022

Needle-free jet injectors have been proposed as an alternative to injections with hypodermic needles. Currently, a handful of commercial needle-free already exist. However, these are designed for specific injections, typically limited large injection volumes into the deeper layers beneath skin. There is growing evidence advantages when delivering small superficial skin layers, namely epidermis and dermis. Injections such vaccines insulin would benefit from delivery layers. Furthermore, same technology volume can serve (medical) tattooing well other personalized medicine treatments. The research dedicated actuated by laser energy has increased in last decade. In this case, absorption optical liquid results explosively bubble. This bubble displaces rest liquid, resulting fast microfluidic which penetrate technique allows precise control over (pL µL) penetration depths (µm mm). be tuned without changing device, varying parameters power, beam diameter filling level container. Despite published on working principles capabilities individual laser-actuated injectors, thorough overview encompassing all them lacking. perspective, we will discuss current status laser-based contrast their limitations, potential challenges.

Язык: Английский

Процитировано

70
Toward closed-loop drug delivery: Integrating wearable technologies with transdermal drug delivery systems DOI
Jyothsna Manikkath,

J. Anand Subramony

Advanced Drug Delivery Reviews, Год журнала: 2021, Номер 179, С. 113997 - 113997

Опубликована: Окт. 9, 2021

Язык: Английский

Процитировано

63
Mind the “Vaccine Fatigue” DOI Creative Commons
Zhaohui Su, Ali Cheshmehzangi, Dean McDonnell

и другие.

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Март 10, 2022

Background Omicron scares and speculations are gaining momentum. Amid the nonstop debates discussions about COVID-19 vaccines, “vaccine fatigue” phenomenon may become more prevalent. However, to date, no research has systematically examined factors that shape people’s vaccine fatigue. To bridge gap, this study aims investigate antecedents cause or catalyze Methods A narrative literature review was conducted in PubMed, Scopus, PsycINFO identify The search completed on December 6, 2021, with a focus scholarly published English. Results total of 37 articles were reviewed analyzed. Vaccine fatigue most frequently discussed context infectious diseases general at pre-vaccination stage. been identified public, parents, doctors. Overall, wide range identified, ranging from frequency immunization demands, side effects, misconceptions severity need for vaccination, lack trust government media. Conclusion is inertia inaction towards information instruction due perceived burden burnout. Our found while some contributors rooted limitations sciences therefore can hardly be avoided, effective empathetic communications hold great promise eliminating preventable across sectors society.

Язык: Английский

Процитировано

63
mRNA nanodelivery systems: targeting strategies and administration routes DOI Creative Commons
Mujie Yuan, Zeyu Han, Yan Liang

и другие.

Biomaterials Research, Год журнала: 2023, Номер 27(1)

Опубликована: Фев. 9, 2023

With the great success of coronavirus disease (COVID-19) messenger ribonucleic acid (mRNA) vaccines, mRNA therapeutics have gained significant momentum for prevention and treatment various refractory diseases. To function efficiently in vivo overcome clinical limitations, demands safe stable vectors a reasonable administration route, bypassing multiple biological barriers achieving organ-specific targeted delivery mRNA. Nanoparticle (NP)-based systems representing leading vector approaches ensure successful intracellular to target organ. In this review, chemical modifications types advanced NPs, including lipid NPs polymers are summarized. The importance passive targeting, especially endogenous active targeting nano-delivery is emphasized, different cellular endocytic mechanisms discussed. Most importantly, based on above content physiological structure characteristics organs vivo, design strategies cells classified Furthermore, influence routes highlighted. Finally, an outlook remaining challenges future development toward therapies precision medicine provided.

Язык: Английский

Процитировано

35
Microneedle‐assisted transdermal delivery of nanoparticles: Recent insights and prospects DOI Creative Commons
Antonio José Guillot, Miquel Martínez‐Navarrete, Valeria Zinchuk‐Mironova

и другие.

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Год журнала: 2023, Номер 15(4)

Опубликована: Апрель 11, 2023

Abstract Transdermal delivery of drugs offers an interesting alternative for the administration molecules that present certain troubles when delivered by oral route. It can produce systemic effects or perform a local action formulation exerts optimal controlled drug release targeted to specific cell type site. also avoids several inconveniences such as hepatic first pass effect, gastric pH‐induced hydrolysis, malabsorption because diseases surgeries, and unpleasant organoleptic properties. Nanomedicine microneedle array patches (MAPs) are two trendiest systems applied transdermal research nowadays. However, skin is protective barrier nanoparticles (NPs) cannot through intact stratum corneum . The association NPs MAPs (NPs@MAPs) work synergistically, since assist bypass outer layers, contribute system providing delivery. Vaccination tailored therapies have been proposed fields where both great potential due inherent characteristics. conception easy use could allow self‐administration therefore facilitate mass vaccination campaigns in undeveloped areas with weak healthcare services. Additionally, nanomedicine being explored platform personalize important field oncology. In this we show recent insights prove benefits NPs@MAPs analyze prospects discrete interest industry NPs@MAPs, evaluating different limiting steps restricts translation clinical practice. This article categorized under: Nanotechnology Approaches Biology > NA Therapeutic Drug Discovery

Язык: Английский

Процитировано

27
Roles of Lipids in the Permeability Barriers of Skin and Oral Mucosa DOI Open Access
Philip W. Wertz

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(10), С. 5229 - 5229

Опубликована: Май 15, 2021

PubMed searches reveal much literature regarding lipids in barrier function of skin and less on the oral mucosa. In terrestrial mammals, birds, reptiles, skin’s permeability is provided by ceramides, fatty acids, cholesterol outermost layers epidermis, stratum corneum. This layer consists about 10–20 cornified cells embedded a lipid matrix. It effectively prevents loss water electrolytes from underlying tissue, it limits penetration potentially harmful substances environment. cavity, regions gingiva hard palate are covered keratinized epithelia that resemble epidermis. The corneum contains mixture similar to epidermal but lower amounts accordingly more permeable. superficial nonkeratinized also provide barrier. These epithelial do contain cholesterol, free which may underlie function. barriers primarily protect tissue preventing toxic substances, including microbial products. Transdermal drug delivery, buccal absorption, lipid-related disease discussed.

Язык: Английский

Процитировано

52
A single subcutaneous or intranasal immunization with adenovirus‐based SARS‐CoV‐2 vaccine induces robust humoral and cellular immune responses in mice DOI Creative Commons
Eun Ran Kim, Florian Weisel, Stephen C. Balmert

и другие.

European Journal of Immunology, Год журнала: 2021, Номер 51(7), С. 1774 - 1784

Опубликована: Март 27, 2021

Optimal vaccines are needed for sustained suppression of SARS-CoV-2 and other novel coronaviruses. Here, we developed a recombinant type 5 adenovirus vector encoding the gene S1 subunit antigen (Ad5.SARS-CoV-2-S1) COVID-19 immunization evaluated its immunogenicity in mice. A single with Ad5.SARS-CoV-2-S1 via S.C. injection or I.N delivery induced robust antibody cellular immune responses. Vaccination elicited significant S1-specific IgG, IgG1, IgG2a endpoint titers as early 2 weeks, antibodies were long lasting. I.N. administration produced GC B cells cervical axillary LNs, respectively. Moreover, evoked significantly greater antigen-specific T-cell responses compared to unimmunized control groups indications that was more effective than eliciting Mice vaccinated by either route demonstrated increased virus-specific neutralization on weeks 8 12 groups, well BM forming (AFC), indicative long-term immunity. Thus, this Ad5-vectored vaccine candidate showed promising following mice routes administration, supporting further development Ad-based against infectious diseases sustainable global programs.

Язык: Английский

Процитировано

42
Targeting strategies for mRNA delivery DOI Creative Commons

Randall A. Meyer,

Sarah Y. Neshat, Jordan J. Green

и другие.

Materials Today Advances, Год журнала: 2022, Номер 14, С. 100240 - 100240

Опубликована: Апрель 12, 2022

mRNA gene therapy has recently emerged as a candidate to enable multiple therapeutic applications including protein replacement therapy, vaccine immunology, and regenerative medicine. Despite the extensive potential, successful clinical translation of therapies been very limited in practice due inadequate understanding how target various organs or cell type for expression. Multiple studies past decade have demonstrated carrier material properties routes administration significant parameters influencing expression profile therapeutics. However, disparate nature these reports prevented critical global factors contribute organ targeting delivery. Elucidation trends commonalities materials achieving tissue specific delivery may realization medical commercial promise medicines. The purpose this review is provide thorough robust meta-analysis that successfully used different article summarizes distinct well evaluates therapeutics can be achieved. This will therefore serve useful guide community development future full potential nucleic acid modality therapy.

Язык: Английский

Процитировано

39
Principles for optimization and validation of mRNA lipid nanoparticle vaccines against COVID-19 using 3D bioprinting DOI
Massimiliano Papi, Daniela Pozzi, Valentina Palmieri

и другие.

Nano Today, Год журнала: 2022, Номер 43, С. 101403 - 101403

Опубликована: Янв. 20, 2022

Язык: Английский

Процитировано

37