Current advance of nanotechnology in diagnosis and treatment for malignant tumors

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Авг. 12, 2024

Cancer remains a significant risk to human health. Nanomedicine is new multidisciplinary field that garnering lot of interest and investigation. shows great potential for cancer diagnosis treatment. Specifically engineered nanoparticles can be employed as contrast agents in diagnostics enable high sensitivity high-resolution tumor detection by imaging examinations. Novel approaches labeling are also made possible the use nanoprobes nanobiosensors. The achievement targeted medication delivery therapy accomplished through rational design manufacture nanodrug carriers. Nanoparticles have capability effectively transport medications or gene fragments tissues via passive active targeting processes, thus enhancing treatment outcomes while minimizing harm healthy tissues. Simultaneously, context radiation sensitization photothermal enhance therapeutic efficacy malignant tumors. This review presents literature overview summary how nanotechnology used According oncological diseases originating from different systems body combining pathophysiological features cancers at sites, we most recent developments applications. Finally, briefly discuss prospects challenges cancer.

Язык: Английский

---

Multiple nano-drug delivery systems for intervertebral disc degeneration: Current status and future perspectives

Bioactive Materials, Год журнала: 2022, Номер 23, С. 274 - 299

Опубликована: Ноя. 20, 2022

Low back pain (LBP) is a common disease that imposes huge social and economic burden on people. Intervertebral disc (IVD) degeneration (IVDD) often considered to be the leading cause of LBP further aggravate serious spinal problems. The established treatment strategy for IVDD consists physiotherapy, medication by drug therapy, and, if necessary, surgery, but none them can treated from etiology; is, it cannot fundamentally reverse IVD reconstruct mechanical function spine. With development nanotechnology regenerative medicine, nano-drug delivery systems (NDDSs) have improved results because their good biodegradability, biocompatibility, precise targeted specific delivery, prolonged release time, enhanced efficacy, various new NDDSs drugs, proteins, cells, genes brought light hope IVDD. This review summarizes research progress in provides prospects using address challenges We ideas generated this will provide insight into

Язык: Английский

---

Nanoparticles Synergize Ferroptosis and Cuproptosis to Potentiate Cancer Immunotherapy

Advanced Science, Год журнала: 2024, Номер 11(23)

Опубликована: Март 13, 2024

Abstract The recent discovery of copper‐mediated and mitochondrion‐dependent cuproptosis has aroused strong interest in harnessing this novel mechanism cell death for cancer therapy. Here the design a core‐shell nanoparticle, CuP/Er, co‐delivery copper (Cu) erastin (Er) to cells synergistic ferroptosis is reported. anti‐Warburg effect Er sensitizes tumor Cu‐mediated cuproptosis, leading irreparable mitochondrial damage by depleting glutathione enhancing lipid peroxidation. CuP/Er induces immunogenic death, enhances antigen presentation, upregulates programmed death‐ligand 1 expression. Consequently, promotes proliferation infiltration T cells, when combined with immune checkpoint blockade, effectively reinvigorates mediate regression murine colon adenocarcinoma triple‐negative breast prevent metastasis. This study suggests unique opportunity synergize combination therapy nanoparticles elicit antitumor effects potentiate current immunotherapies.

Язык: Английский

---

Dendritic Polymer‐Based Nanomedicines Remodel the Tumor Stroma: Improve Drug Penetration and Enhance Antitumor Immune Response

Advanced Materials, Год журнала: 2024, Номер 36(25)

Опубликована: Март 12, 2024

Abstract The dense extracellular matrix (ECM) in solid tumors, contributed by cancer‐associated fibroblasts (CAFs), hinders penetration of drugs and diminishes their therapeutic outcomes. A sequential treatment strategy remodeling the ECM via a CAF modifier (dasatinib, DAS) is proposed to promote an immunogenic cell death (ICD) inducer (epirubicin, Epi) apoptotic vesicles, ultimately enhancing efficacy against breast cancer. Dendritic poly(oligo(ethylene glycol) methyl ether methacrylate) (POEGMA)‐based nanomedicines (poly[OEGMA‐Dendron(G2)‐Gly‐Phe‐Leu‐Gly‐DAS] (P‐DAS) poly[OEGMA‐Dendron(G2)‐hydrazone‐Epi] (P‐Epi)) are developed for delivery DAS Epi, respectively. P‐DAS reprograms CAFs reduce collagen downregulating anabolism energy metabolism, thereby reducing deposition. regulated can enhance tumor P‐Epi strengthen its ICD effect, leading amplified antitumor immune response. In cancer‐bearing mice, this approach alleviates barrier, resulting reduced burden increased cytotoxic T lymphocyte infiltration, more encouragingly, synergizes effectively with anti‐programmed 1 (PD‐1) therapy, significantly inhibiting growth preventing lung metastasis. Furthermore, systemic toxicity barely detectable after P‐Epi. This opens new avenue treating desmoplastic tumors metabolically targeting overcome barrier.

Язык: Английский

---

Two-Stage SN38 Release from a Core–Shell Nanoparticle Enhances Tumor Deposition and Antitumor Efficacy for Synergistic Combination with Immune Checkpoint Blockade

ACS Nano, Год журнала: 2022, Номер 16(12), С. 21417 - 21430

Опубликована: Ноя. 16, 2022

Long-circulating nanomedicines efficiently deliver chemotherapies to tumors reduce general toxicity. However, extended blood circulation of can increase drug exposure leukocytes and lead hematological Here, we report a two-stage release strategy enhance the deposition antitumor efficacy OxPt/SN38 core–shell nanoparticles with hydrophilic oxaliplatin (OxPt) prodrug coordination polymer core lipid shell containing hydrophobic cholesterol-conjugated SN38 (Chol-SN38). By conjugating cholesterol phenol group via an acetal linkage protecting 20-hydroxy position trimethylsilyl (TMS) group, Chol-SN38 releases in two stages esterase-catalyzed cleavage liver followed by acid-mediated hydrolysis TMS preferentially tumors. Compared irinotecan, reduces 9.0 times increases tumor 4.7 times. As result, inhibits growth on subcutaneous, spontaneous, metastatic models causing apoptotic immunogenic cell death. exhibits strong synergy immune checkpoint blockade regress subcutaneous colorectal pancreatic 33–50% cure rates greatly invasion spontaneous prostate cancer model metastasis without side effects. Mechanistic studies revealed important roles enhanced death upregulated PD-L1 expression activating microenvironment elicit potent immunity. This work highlights potential combining innovative design nanomedicine formulation address unmet needs therapy.

Язык: Английский

---

miRNAs orchestration of gallbladder cancer – Particular emphasis on diagnosis, progression and drug resistance

Pathology - Research and Practice, Год журнала: 2023, Номер 248, С. 154684 - 154684

Опубликована: Июль 13, 2023

Язык: Английский

---

Theranostics applications of quantum dots in regenerative medicine, cancer medicine, and infectious diseases

Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 200, С. 114863 - 114863

Опубликована: Май 6, 2023

Quantum dots (QDs) have attracted attention for their application and commercialization in all industrial fields, including communications, displays, solar cells, due to excellent optical properties based on the quantum size effect. In recent years, development of QDs that do not contain cadmium which is toxic cells living organisms, has progressed, they considerable bio-imaging field targeting molecules cells. Furthermore, recently, need diagnostics treatment at single molecule cell level medical been increasing, also accelerating. Therefore, this paper outlines frontiers diagnostic therapeutic applications (theranostics) QDs, especially advanced fields such as regenerative medicine, oncology, infectious diseases.

Язык: Английский

---

Targeted Nanoparticle-Based Diagnostic and Treatment Options for Pancreatic Cancer

Cancers, Год журнала: 2024, Номер 16(8), С. 1589 - 1589

Опубликована: Апрель 20, 2024

Pancreatic ductal adenocarcinoma (PDAC), one of the deadliest cancers, presents significant challenges in diagnosis and treatment due to its aggressive, metastatic nature lack early detection methods. A key obstacle PDAC is highly complex tumor environment characterized by dense stroma surrounding tumor, which hinders effective drug delivery. Nanotechnology can offer innovative solutions these challenges, particularly creating novel delivery systems for existing anticancer drugs PDAC, such as gemcitabine paclitaxel. By using customization methods incorporating conjugated targeting ligands, tumor-penetrating peptides, therapeutic nucleic acids, nanoparticle-based enhance solubility, extend circulation time, improve targeting, control release, thereby minimizing side effects toxicity healthy tissues. Moreover, nanoparticles have also shown potential precise diagnostic PDAC. This literature review will delve into targeted mechanisms, pathways, approaches treating pancreatic cancer. Additional emphasis placed on study systems, with a brief mention those clinical trials. Overall, overview illustrates advances nanomedicine, underscoring role transcending constraints conventional therapies diagnostics.

Язык: Английский

---

Recent advancements in Irinotecan-loaded nanomaterials as a smart drug delivery system for cancer therapy: A state-of-art-review

Inorganic Chemistry Communications, Год журнала: 2024, Номер 161, С. 112028 - 112028

Опубликована: Янв. 9, 2024

Язык: Английский

---

Harnessing nanotechnology for cancer treatment

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 12

Опубликована: Янв. 20, 2025

Nanotechnology has become a groundbreaking innovation force in cancer therapy, offering innovative solutions to the limitations of conventional treatments such as chemotherapy and radiation. By manipulating materials at nanoscale, researchers have developed nanocarriers capable targeted drug delivery, improving therapeutic efficacy while reducing systemic toxicity. Nanoparticles like liposomes, dendrimers, polymeric nanomaterials shown significant promise delivering chemotherapeutic agents directly tumor sites, enhancing bioavailability minimizing damage healthy tissues. In addition with utilization tools quantum dots nanosensors that enables more precise identification biomarkers, nanotechnology is also playing pivotal role early detection diagnosis. Furthermore, nanotechnology-based strategies, including photothermal gene therapy immunotherapy are novel ways combat by selectively targeting cells immune response. Nevertheless, despite these progressions, obstacles still persist, particularly clinical translation technologies. Issues nanoparticle toxicity, biocompatibility, complexity regulatory approval hinder widespread adoption nanomedicine oncology. This review discusses different applications highlighting its potential hurdles implementation. Future research needs concentrate on addressing unlock full providing personalized, effective, minimally invasive treatments.

Язык: Английский

---