Lipid Prodrug Nanoassemblies via Dynamic Covalent Boronates

ACS Nano, Год журнала: 2023, Номер 17(7), С. 6601 - 6614

Опубликована: Март 31, 2023

Prodrug nanoassemblies combine the advantages of prodrug and nanomedicines, offering great potential in targeting lesion sites specific on-demand drug release, maximizing therapeutic performance while minimizing their side effects. However, there is still lacking a facile pathway to prepare lipid (LPNAs). Herein, we report LPNAs via dynamic covalent boronate between catechol boronic acid. The resulting possess properties like loading manner, charge reversal an acidic microenvironment, release at and/or oxidative microenvironment. Our methodology enables encapsulation delivery three model drugs: ciprofloxacin, bortezomib, miconazole. Moreover, are often more efficient eradicating pathogens or cancer cells than free counterparts, both vitro vivo. Together, our with intriguing may boost development facilitate clinical applications.

Язык: Английский

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Immunogenicity of Extracellular Vesicles

Advanced Materials, Год журнала: 2024, Номер 36(33)

Опубликована: Июнь 27, 2024

Extracellular vesicles (EVs) are promising next-generation therapeutics and drug delivery systems due to demonstrated safety efficacy in preclinical models early-stage clinical trials. There is an urgent need address the immunogenicity of EVs (beyond apparent lack immunotoxicity) advance development. To date, few studies have assessed unintended immunological recognition EVs. An in-depth understanding EV-induced clearance necessary develop effective therapeutic strategies, including approaches mitigate when undesired. This article summarizes various factors involved potential strategies reduce for improved benefit.

Язык: Английский

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Research Progress of SN38 Drug Delivery System in Cancer Treatment

International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 945 - 964

Опубликована: Янв. 1, 2024

Abstract: The active metabolite of irinotecan (CPT-11), 7-ethyl-10-hydroxycamptothecin (SN38), is 100– 1000 times more than CPT-11 and has shown inhibitory effects on a range cancer cells, including those from the rectal, small cell lung, breast, esophageal, uterine, ovarian malignancies. Despite SN38's potent anticancer properties, its hydrophobicity pH instability have caused substantial side activity loss, which make it difficult to use in clinical settings. To solve above problems, construction SN38-based drug delivery systems one most feasible methods improve solubility, enhance stability, increase targeting ability, bioavailability, therapeutic efficacy reduce adverse reactions. Therefore, based mechanism systems, this paper reviews SN38 polymeric micelles, liposomal nanoparticles, protein conjugated targeted by aptamers ligands, antibody-drug couplings, magnetic targeting, photosensitive redox-sensitive multi-stimulus-responsive co-loaded systems. focus review nanocarrier-based We hope provide reference for translation application novel medications. Keywords: SN38, system,

Язык: Английский

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Biomaterials with cancer cell-specific cytotoxicity: challenges and perspectives

Chemical Society Reviews, Год журнала: 2024, Номер 53(17), С. 8847 - 8877

Опубликована: Янв. 1, 2024

Significant advances have been made in materials for biomedical applications, including tissue engineering, bioimaging, cancer treatment,

Язык: Английский

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Metformin‐Mediated Immunosuppressive Microenvironment Remodeling in Combination with Chemotherapy via a Spatial‐Specific Multi‐Responsive Carrier‐Free Self‐Assembled Nanoparticle

Advanced Functional Materials, Год журнала: 2024, Номер 34(25)

Опубликована: Янв. 28, 2024

Abstract The complex tumor immune pathology requires a precise spatial‐control release of the combination drugs, but most multi‐drug loaded nanoparticles all drugs simultaneously in microenvironment (TME), making them difficult to reach exact action site. To address spatial specific carrier‐free self‐assembled multi‐responsive nanodrug delivery system is designed, which p ‐phthalaldehyde ( ‐APA) and dithiodipropionic acid are used connect metformin (MET) 7‐ethyl‐10‐hydroxycamptothecin (SN38) through matrix metalloproteinase‐2 (MMP‐2) responsive peptide, dipyridamole (DIP) further (MA‐GPLGVRGDK‐SS‐SN38@DIP, MR NPs). NPs first target by enhanced permeability retention effect, then highly expressed MMP‐2 at site cleaves GPLGVRGDK, breaking nanoparticle into three parts—DIP, MA‐GPLG, VRGDK‐SS‐SN38. DIP automatically binds with platelets TME, inhibiting their function restraining metastasis. MA‐GPLG releases MET response acidic TME reverse immunosuppressive networks PD‐L1 downregulation M2‐like macrophages repolarization. Moreover, VRGDK‐SS‐SN38 overexpressed integrin α v β 3 receptor achieve cells killing. Overall, this study offers an intelligent spatial‐specific drug breast cancer, specifically, therefore reverses inhibits

Язык: Английский

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Nanotherapeutics for prostate cancer treatment: A comprehensive review

Biomaterials, Год журнала: 2024, Номер 305, С. 122469 - 122469

Опубликована: Янв. 16, 2024

Язык: Английский

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STING activation disrupts tumor vasculature to overcome the EPR limitation and increase drug deposition

Science Advances, Год журнала: 2024, Номер 10(29)

Опубликована: Июль 17, 2024

The low success rate of cancer nanomedicines has raised debate on the role enhanced permeability and retention (EPR) effect tumor deposition nanotherapeutics. Here, we report a bifunctional nanoscale coordination polymer (NCP), oxaliplatin (OX)/2′,3′-cyclic guanosine monophosphate–adenosine monophosphate (GA), to overcome EPR limitation through stimulator interferon genes (STING) activation enhance chemotherapeutic STING agonist delivery for eradication. OX/GA encapsulates GA OX in NCP protect from enzymatic degradation improve pharmacokinetics. by disrupts vasculatures increases intratumoral 4.9-fold over monotherapy OX-NCP. demonstrates exceptional antitumor effects with >95% growth inhibition high cure rates subcutaneous, orthotopic, spontaneous, metastatic models. induces immunogenic cell death cells innate immune antigen presentation. NCPs provide an excellent nanoplatform effective therapy.

Язык: Английский

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Camptothecin-based prodrug nanomedicines for cancer therapy

Nanoscale, Год журнала: 2023, Номер 15(44), С. 17658 - 17697

Опубликована: Янв. 1, 2023

Camptothecin (CPT) is a cytotoxic alkaloid that attenuates the replication of cancer cells via blocking DNA topoisomerase 1.

Язык: Английский

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Combination Therapy of Lox Inhibitor and Stimuli‐Responsive Drug for Mechanochemically Synergistic Breast Cancer Treatment

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(21)

Опубликована: Апрель 26, 2023

Chemotherapy based on small molecule drugs, hormones, cycline kinase inhibitors, and monoclonal antibodies has been widely used for breast cancer treatment in the clinic but with limited efficacy, due to poor specificity tumor microenvironment (TME)-caused diffusion barrier. Although monotherapies targeting biochemical cues or physical TME have developed, none of them can cope complex TME, while mechanochemical combination therapy remains largely be explored. Herein, a strategy an extracellular matrix (ECM) modulator TME-responsive drug first attempt mechanochemically synergistic is developed. Specifically, overexpressed NAD(P)H quinone oxidoreductase 1 (NQO1) cancer, (NQO1-SN38) designed it combined inhibitor (i.e., β-Aminopropionitrile, BAPN) Lysyl oxidases (Lox) that contributes stiffness, therapy. It demonstrated NQO1 trigger degradation NQO1-SN38 release SN38, showing nearly twice inhibition efficiency compared SN38 vitro. Lox BAPN significantly reduces collagen deposition enhances penetration heterospheroids further showed outstanding therapeutic efficacy vivo, providing promising approach

Язык: Английский

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Ratiometric optical probes for biosensing

Theranostics, Год журнала: 2023, Номер 13(8), С. 2632 - 2656

Опубликована: Янв. 1, 2023

Biosensing by optical probes is bringing about a revolution in our understanding of physiological and pathological states.Conventional for biosensing are prone to inaccurate detection results due various analyte-independent factors that can lead fluctuations the absolute signal intensity.Ratiometric provide built-in self-calibration correction more sensitive reliable detection.Probes specifically developed ratiometric have been shown significantly improve sensitivity accuracy biosensing.In this review, we focus on advancements sensing mechanism including photoacoustic (PA) probes, fluorescence (FL) bioluminescence (BL) chemiluminescence (CL) afterglow probes.The versatile design strategies these discussed along with broad range applications such as pH, enzymes, reactive oxygen species (ROS), nitrogen (RNS), glutathione (GSH), metal ions, gas molecules hypoxia factors, well resonance energy transfer (FRET)-based immunoassay biosensing.Finally, challenges perspectives discussed.

Язык: Английский

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