Coordination Chemistry Reviews, Год журнала: 2025, Номер 534, С. 216587 - 216587
Опубликована: Март 14, 2025
Язык: Английский
Progress in Materials Science, Год журнала: 2024, Номер 147, С. 101347 - 101347
Опубликована: Июль 30, 2024
Язык: Английский
Процитировано
6
Journal of Photochemistry and Photobiology C Photochemistry Reviews, Год журнала: 2024, Номер 59, С. 100665 - 100665
Опубликована: Июнь 1, 2024
Язык: Английский
Процитировано
5
ACS Nano, Год журнала: 2024, Номер 18(39), С. 26784 - 26798
Опубликована: Сен. 20, 2024
Accurate imaging and precise treatment are critical to controlling the progression of pancreatic cancer. However, current approaches for cancer theranostics suffer from limitations in tumor specificity invasive surgery. Herein, a cancer-specific phototheranostic modulator (AuHQ) dominated by aggregation-induced emission (AIE) luminogens-tethered gold nanoparticles is meticulously designed facilitate prominent fluorescence-photoacoustic bimodal imaging-guided photothermal immunotherapy. Once reaching microenvironment (TME), peptide Ala-Gly-Phe-Ser-Leu-Pro-Ala-Gly-Cys (AGFSLPAGC) linkage within AuHQ can be specifically cleaved overexpressed enzyme Cathepsin E (CTSE), triggering dual self-assembly AuNPs AIE luminogens. The aggregation mediated enzymatic cleavage results potentiated therapy (PTT) under near-infrared (NIR) laser irradiation, induced immunogenic cell death (ICD), enhanced photoacoustic imaging. Simultaneously, luminogen aggregates formed hydrophobic interaction generate fluorescence, enabling real-time specific fluorescence Furthermore, coadministration an indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with address PTT efficacy imposed immunosuppressive TME leverage synergistic potential activate systemic antitumor immunity. Thus, this well-designed facilitates intelligent therapeutic agents, providing efficient approach theranostics.
Язык: Английский
Процитировано
4
Advanced Materials, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 26, 2024
Abstract Phototheranositcs has recently aroused extreme attention due to its exceptional advantages. However, the poor photothernostic efficiency, limited penetration depth, strong oxygen‐dependence, and inevitable damage normal tissue of conventional materials severely hindered their total theranostic efficacy. Herein, a series near‐infrared second (NIR‐II) photosensitizers (PSs) featuring aggregation‐induced emission (AIE), NIR‐II fluorescence imaging (FLI), type I photodynamic therapy (PDT) mild‐temperature photothermal (PTT) are constructed through dual‐strategy methods combining donor group engineering fluorination engineering. Profiting from sufficient molecular rotors high electronegativity fluorine, developed 2‐(2‐((5‐(4‐((4‐(diphenylamino)phenyl)(phenyl)amino)phenyl)thiophen‐2‐yl)methylene)‐5,6‐difluoro‐3‐oxo‐2,3‐dihydro‐1H‐inden‐1‐ylidene)malononitrile (BTS‐2F) 2‐(2‐((5‐(4‐(bis(4‐(diphenylamino)phenyl)amino)phenyl)thiophen‐2‐yl)methylene)‐5,6‐difluoro‐3‐oxo‐2,3‐dihydro‐1H‐inden‐1‐ylidene)malononitrile (TTS‐2F) endowed with AIE property, radical reactive oxygen species (ROS) generation ability conversion. Through thin film hydration method, prepared BTS‐2F TTS‐2F loaded liposomes exhibit significant FLI improved type‐I PDT/mild‐temperature PTT under laser irradiation both in vitro orthotopic 4T1 mice models.
Язык: Английский
Процитировано
4
Journal of Materials Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 8, 2025
Язык: Английский
Процитировано
0
Chinese Chemical Letters, Год журнала: 2025, Номер unknown, С. 110832 - 110832
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Materials Today Chemistry, Год журнала: 2025, Номер 43, С. 102516 - 102516
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Aggregate, Год журнала: 2025, Номер unknown
Опубликована: Янв. 20, 2025
ABSTRACT Human papillomavirus (HPV) is a highly prevalent venereal pathogen accounting for genital warts and various cancers like cervical, anal, oropharyngeal cancers. Although imiquimod, topical medication, commonly used to treat induced by HPV, its potential as an in situ immune response regulator HPV‐related has rarely been explored. In this study, we developed innovative synergistic therapeutic platform integrating near‐infrared‐II (NIR‐II) absorbing aggregation‐induced emission (AIE) agent (TPE‐BT‐BBTD) imiquimod into injectable hydrogel named TIH. TPE‐BT‐BBTD molecule that serves photothermal agent, with exposure 1064 nm laser, effectively destroys tumor cells releases tumor‐related antigens. During the thermogenesis process, melts imiquimod. The released conjunction dead antigens, stimulates dendritic cell maturation, activating system ultimately eliminate residual cancer cells. This novel approach combines immunomodulatory effects of nm‐excitable delivery system, offering promising tactic combating HPV‐associated
Язык: Английский
Процитировано
0
Analytical Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 25, 2025
Lymphoma is a malignant cancer characterized by rapidly increasing incidence, complex etiology, and lack of obvious early symptoms. Efficient theranostics lymphoma great significance in improving patient outcomes, empowering informed decision-making, driving medical innovation. Herein, we developed multifunctional nanoplatform for precise optical imaging therapy based on new photosensitizer (1-oxo-1H-benzoo[de]anthracene-2,3-dicarbonitrile-triphenylamine (OBADC-TPA)). OBADC-TPA donor-acceptor (D-A) molecule novel small coplanar strong electron-withdrawing acceptor skeleton, while the OBADC moiety facilitates intramolecular charge transfer. OBADC-TPA-based nanoparticles (NPs) were prepared through encapsulation with an amphiphilic polymer subsequent modification sialic acid (SA). Both vitro vivo studies demonstrated that NPs-SA possessed good biocompatibility, effective tumor accumulation, high photoacoustic (PA) contrast, bright second near-infrared (NIR-II) fluorescence emission, efficient photothermal/photodynamic conversion capabilities, which can serve as nanocomposite targeted PA/NIR-II imaging-guided synergistic type I/II photodynamic photothermal (PDT/PTT) lymphoma. This work not only provides NIR-II fluorophore but also offers new, accurate, approach diagnosis treatment lymphoma, holding promising prospects clinical application.
Язык: Английский
Процитировано
0
Biomaterials Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
This minireview highlights recent developments in near-infrared organic photosensitizers for photodynamic cancer therapy. The challenges and future prospects of this promising research field are also discussed.
Язык: Английский
Процитировано
0