Intensive and Persistent Chemiluminescence from Orderly Arranged Ligands within Metal–Organic Frameworks for Inflammation Imaging DOI
Hongxu Chen, Wenqian Cao, Yuanjing Cui

et al.

Inorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Chemiluminescence offers ultrasensitive imaging for the diagnosis of a variety diseases by removing interference from excitation light sources. Here, we prepared two chemiluminescent metal-organic frameworks (Mn-ADA and Zn-ADA) using (2E,2'E)-3,3'-(anthracene-9,10-diyl)diacrylic acid (ADA) as ligand. In Mn-ADA Zn-ADA, Mn atoms Zn are six-coordinated eight-coordinated, respectively, their different in spatial structure. Due to orderly arrangement fluorescence ligands one-dimensional channel control diffusion reactant, exhibits superstrong intensity persistent chemiluminescence compared ADA. The is 43 times higher, lifetime longer than that Furthermore, coordination also causes be stronger Zn-ADA. It established can detect H2O2 image inflammation mice without light. This methodology demonstrates potential (MOFs) enhance new avenue development MOF materials intended biomedical application.

Language: Английский

Phototherapeutic nanoagents for cancer immunotherapy DOI
Maomao He,

M. Xiao,

Ran Wang

et al.

Progress in Materials Science, Journal Year: 2024, Volume and Issue: 147, P. 101347 - 101347

Published: July 30, 2024

Language: Английский

Citations

6
Progress and Promise of Photoresponsive Nanocarriers for Precision Drug Delivery in Cancer DOI
Neeraj S. Thakur,

Nada Saleh,

Ali Fahim Khan

et al.

Journal of Photochemistry and Photobiology C Photochemistry Reviews, Journal Year: 2024, Volume and Issue: 59, P. 100665 - 100665

Published: June 1, 2024

Language: Английский

Citations

5
Engineering AIEgens-Tethered Gold Nanoparticles with Enzymatic Dual Self-Assembly for Amplified Cancer-Specific Phototheranostics DOI
Jiayi Bian,

Yingjie Xu,

M. Sun

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(39), P. 26784 - 26798

Published: Sept. 20, 2024

Accurate imaging and precise treatment are critical to controlling the progression of pancreatic cancer. However, current approaches for cancer theranostics suffer from limitations in tumor specificity invasive surgery. Herein, a cancer-specific phototheranostic modulator (AuHQ) dominated by aggregation-induced emission (AIE) luminogens-tethered gold nanoparticles is meticulously designed facilitate prominent fluorescence-photoacoustic bimodal imaging-guided photothermal immunotherapy. Once reaching microenvironment (TME), peptide Ala-Gly-Phe-Ser-Leu-Pro-Ala-Gly-Cys (AGFSLPAGC) linkage within AuHQ can be specifically cleaved overexpressed enzyme Cathepsin E (CTSE), triggering dual self-assembly AuNPs AIE luminogens. The aggregation mediated enzymatic cleavage results potentiated therapy (PTT) under near-infrared (NIR) laser irradiation, induced immunogenic cell death (ICD), enhanced photoacoustic imaging. Simultaneously, luminogen aggregates formed hydrophobic interaction generate fluorescence, enabling real-time specific fluorescence Furthermore, coadministration an indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor with address PTT efficacy imposed immunosuppressive TME leverage synergistic potential activate systemic antitumor immunity. Thus, this well-designed facilitates intelligent therapeutic agents, providing efficient approach theranostics.

Language: Английский

Citations

4
NIR‐II AIE Liposomes for Boosting Type‐I Photodynamic and Mild‐Temperature Photothermal Therapy in Breast Cancer Treatment DOI Open Access
Shijie Zhen, Zhe Xu,

Meng Suo

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Abstract Phototheranositcs has recently aroused extreme attention due to its exceptional advantages. However, the poor photothernostic efficiency, limited penetration depth, strong oxygen‐dependence, and inevitable damage normal tissue of conventional materials severely hindered their total theranostic efficacy. Herein, a series near‐infrared second (NIR‐II) photosensitizers (PSs) featuring aggregation‐induced emission (AIE), NIR‐II fluorescence imaging (FLI), type I photodynamic therapy (PDT) mild‐temperature photothermal (PTT) are constructed through dual‐strategy methods combining donor group engineering fluorination engineering. Profiting from sufficient molecular rotors high electronegativity fluorine, developed 2‐(2‐((5‐(4‐((4‐(diphenylamino)phenyl)(phenyl)amino)phenyl)thiophen‐2‐yl)methylene)‐5,6‐difluoro‐3‐oxo‐2,3‐dihydro‐1H‐inden‐1‐ylidene)malononitrile (BTS‐2F) 2‐(2‐((5‐(4‐(bis(4‐(diphenylamino)phenyl)amino)phenyl)thiophen‐2‐yl)methylene)‐5,6‐difluoro‐3‐oxo‐2,3‐dihydro‐1H‐inden‐1‐ylidene)malononitrile (TTS‐2F) endowed with AIE property, radical reactive oxygen species (ROS) generation ability conversion. Through thin film hydration method, prepared BTS‐2F TTS‐2F loaded liposomes exhibit significant FLI improved type‐I PDT/mild‐temperature PTT under laser irradiation both in vitro orthotopic 4T1 mice models.

Language: Английский

Citations

4
Advances in phototheranostic agents: From imaging to targeted therapy DOI

M. Samadzadeh,

Arezoo Khosravi, Atefeh Zarepour

et al.

Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 43, P. 102516 - 102516

Published: Jan. 1, 2025

Language: Английский

Citations

0
An NIR‐II Absorbing Injectable Hydrogel for Boosted Photo‐Immunotherapy Toward Human Papillomavirus Associated Cancer DOI Creative Commons
Xinghua Yu,

Lingan Zeng,

Xinyue Yang

et al.

Aggregate, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

ABSTRACT Human papillomavirus (HPV) is a highly prevalent venereal pathogen accounting for genital warts and various cancers like cervical, anal, oropharyngeal cancers. Although imiquimod, topical medication, commonly used to treat induced by HPV, its potential as an in situ immune response regulator HPV‐related has rarely been explored. In this study, we developed innovative synergistic therapeutic platform integrating near‐infrared‐II (NIR‐II) absorbing aggregation‐induced emission (AIE) agent (TPE‐BT‐BBTD) imiquimod into injectable hydrogel named TIH. TPE‐BT‐BBTD molecule that serves photothermal agent, with exposure 1064 nm laser, effectively destroys tumor cells releases tumor‐related antigens. During the thermogenesis process, melts imiquimod. The released conjunction dead antigens, stimulates dendritic cell maturation, activating system ultimately eliminate residual cancer cells. This novel approach combines immunomodulatory effects of nm‐excitable delivery system, offering promising tactic combating HPV‐associated

Language: Английский

Citations

0
Advances on fluorescence bioimaging and photo-mediated therapy of NIR-II small molecule dyes DOI
Weijie Zhang,

Laraib,

Fangjun Huo

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 534, P. 216587 - 216587

Published: March 14, 2025

Language: Английский

Citations

0
Design of A3B-Porphyrin Conjugates with Terpyridine as Potential Theranostic Agents: Synthesis, Complexation with Fe(III), Gd(III), and Photodynamic Activity DOI Creative Commons
Kseniya A. Zhdanova,

Anastasia V. Ivantsova,

Fedor Yu. Vyalba

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(1), P. 269 - 269

Published: Jan. 12, 2023

This paper reports on the design and synthesis of new multifunctional porphyrin-based therapeutic agents for potential diagnostic applications. Zinc complexes A3B-type meso-arylporphyrins containing OH- COOH- groups were modified with chelating ligands based 4'-(4-methylphenyl)-2,2':6',2″-terpyridine derivatives in high yields. Novel Gd(III), Fe(III) obtained these conjugates. Aggregation behaviour solutions different solubilisers was studied to inform selection optimal solubilising platform porphyrins obtained; their photophysical photochemical properties also characterised. Micellar Pluronic F127 formulation found be most effective solubiliser stabilising fluorescence-active monomolecular form photosensitisers (PS). In vitro cytotoxicity compounds HEP-2 cell line without irradiation 1.5 24 h. As a result, IC50 12 14 at an dose 8.073 J/cm2 shown 1.87 ± 0.333 1.4 0.152 μM, respectively; irradiation, compound had no toxic effect within concentration range (1.5 h). A test inhibition metabolic cooperation or promoter activity performed abovementioned compounds, showing efficacy safety conjugates obtained. Preliminary data have indicated type PS promising molecular theranostic agents.

Language: Английский

Citations

10
Nanostructured organic photosensitizer aggregates in disease phototheranostics DOI
Maochao Zheng, Qianqian Yang, Chao Lü

et al.

Drug Discovery Today, Journal Year: 2023, Volume and Issue: 28(6), P. 103598 - 103598

Published: April 27, 2023

Language: Английский

Citations

10
Bifunctional Tumor-Targeted Bioprobe for Phothotheranosis DOI Creative Commons
Hae Sang Park, Shinya Yokomizo, Haoran Wang

et al.

Biomaterials Research, Journal Year: 2024, Volume and Issue: 28

Published: Jan. 1, 2024

Background: Near-infrared (NIR) phototheranostics provide promising noninvasive imaging and treatment for head neck squamous cell carcinoma (HNSCC), capitalizing on its adjacency to skin or mucosal surfaces. Activated by laser irradiation, targeted NIR fluorophores can selectively eradicate cancer cells, harnessing the power of synergistic photodynamic therapy photothermal therapy. However, there is a paucity bioprobes showing tumor-specific targeting effective phototheranosis without hurting surrounding healthy tissues. Methods: We engineered bifunctional bioprobe designed precisely target HNSCC induce using bioconjugation cyclic arginine-glycine-aspartic acid (cRGD) motif zwitterionic polymethine fluorophore. The cytotoxic effects cRGD-ZW800-PEG were measured assessing heat reactive oxygen species (ROS) generation upon an 808-nm irradiation. then determined in vivo efficacy FaDu xenograft mouse model HNSCC, as well biodistribution clearance, customized portable system. Results: Real-time revealed that intravenously administered tumors rapidly within 4 h postintravenous injection tumor-bearing mice. Upon produced ROS simultaneously exhibited tumoral tissue affecting neighboring Importantly, all unbound cleared through renal excretion. Conclusions: By combination with tailored tumor selectivity, our ushers paradigm treatment. It promises safer more efficacious therapeutic avenues against cancer, marking substantial advancement field.

Language: Английский

Citations

3