Smart Materials in Medicine,
Год журнала:
2022,
Номер
4, С. 313 - 336
Опубликована: Дек. 5, 2022
Nanoscale
metal
is
considered
the
backbone
of
biomedical
nanotechnology.
Recently,
there
has
been
an
exponential
increase
in
nanoscale
materials'
applications.
These
nanomaterials
have
mainly
employed
drug
delivery
systems,
prosthetic
implants,
diagnostics,
and
therapeutics
various
diseases,
including
cancer.
materials
two
major
classes,
namely
organic
inorganic
nanomaterials.
Given
merit
excellent
biocompatibility,
facile
synthesis,
target
recognition,
prolonged
circulation
half-life,
deference
to
surface
functionalization,
(metallic)
nanoparticles
hold
promising
applications
biomedicine.
Their
properties
may
vary
based
on
their
type,
size,
shape,
structure,
origin.
This
review
will
enlighten
recent
advances
as
nanoscale-knife
cancer
theranostics.
Moreover,
external
assisted
technologies
metallic
nanoparticle
decoration
also
be
highlighted.
Biomimetic
nanoparticles
(BioM
NPs)
feature
functionalization
that
imitates
the
biological
surroundings,
endowing
them
with
structure
and
functioning.
BioM
NPs
could
be
covered
biologically
sourced
materials
contain
synthetic
antigen-presenting
cells
structures.
Whenever
used
in
cancer
diagnostics,
outperform
standard
medications
comparable
non-BioM
NPs,
particularly
regarding
circulation
time,
tissue
penetration,
delivery,
toxicity.
The
particles
achieved
extraordinary
results
by
using
cell
material
for
which
avoids
difficult
bottom-up
approaches
aim
to
emulate
such
intricate
diverse
components.
One
area
of
this
rapidly
developing
research
has
gotten
a
lot
interest
is
use
treatment
different
cancers.
However,
best
our
knowledge,
no
published
study
primarily
analysed
current
improvements
therapy,
taking
into
account
most
common
tumours
processes.
As
result,
purpose
present
review
address
gap
first.
discussion
will
next
go
numerous
recent
advances
therapy.
This
cover
mechanics
procedures
as
well
their
utilization
therapeutics.
paper
then
summarizes
existing
knowledge
investigates
limitations
promise
aims
provide
researchers
an
overview
technological
development
It
serves
guide
integrating
future
nanomedicine
applications.
Journal of Xenobiotics,
Год журнала:
2023,
Номер
13(2), С. 172 - 192
Опубликована: Март 25, 2023
The
role
of
intestinal
barrier
homeostasis
in
an
individual's
general
well-being
has
been
widely
addressed
by
the
scientific
community.
Colorectal
cancer
is
among
illnesses
that
most
affect
this
biological
barrier.
While
chemotherapy
first
choice
to
treat
type
cancer,
multidrug
resistance
(MDR)
major
setback
against
commonly
used
drugs,
with
ATP-binding
cassette
transporters
(ABC
transporters)
being
players.
P-glycoprotein
(P-gp),
protein
1
(MRP1),
or
breast
(ABCG2)
efflux
chemotherapeutic
drugs
well
described
cells,
highlighting
these
proteins
as
interesting
druggable
targets
reverse
MDR,
decrease
drug
dosage,
and
consequently
undesired
toxicity.
Natural
products,
especially
phytochemicals,
have
a
wide
diversity
chemical
structures,
some
particular
classes,
such
phenolic
acids,
flavonoids,
pentacyclic
triterpenoids,
reported
inhibitors
P-gp,
MRP1,
ABCG2,
able
sensitize
cells
drugs.
Nevertheless,
ABC
play
vital
cell's
defense
xenobiotics,
phytochemicals
also
shown
induce
transporters'
activity.
A
balance
must
be
obtained
between
xenobiotic
non-tumor
bioaccumulation
which
are
essential
natural
products
pivotal
further
analyzed.
This
review
summarizes
knowledge
concerning
nomenclature
function
ABC-transporters,
emphasizing
their
cells.
In
addition,
it
focuses
on
found
food
e.g.,
modulators
ABC-transporter
activity
expression,
promising
nutraceutical
molecules
formulate
new
combinations
overcome
resistance.
Frontiers in Cell and Developmental Biology,
Год журнала:
2023,
Номер
11
Опубликована: Июль 5, 2023
At
present,
extracellular
vesicles
(EVs)
are
considered
key
candidates
for
cell-free
therapies,
including
treatment
of
allergic
and
autoimmune
diseases.
However,
their
therapeutic
effectiveness,
dependent
on
proper
targeting
to
the
desired
cells,
is
significantly
limited
due
reduced
bioavailability
resulting
from
rapid
clearance
by
cells
mononuclear
phagocyte
system
(MPS).
Thus,
developing
strategies
avoid
EV
elimination
essential
when
applying
them
in
clinical
practice.
On
other
hand,
malfunctioning
MPS
contributes
various
immune-related
pathologies.
Therapeutic
reversal
these
effects
with
EVs
would
be
beneficial
could
achieved,
example,
modulating
macrophage
phenotype
or
regulating
antigen
presentation
dendritic
cells.
Additionally,
intended
macrophages
replication
repackaging
molecules
into
new
vesicle
subtype
can
allow
specific
appropriate
populations
acceptor
Herein,
we
briefly
discuss
under-explored
aspects
MPS-EV
interactions
that
undoubtedly
require
further
research
order
accelerate
use
EVs.
Abstract
The
rapid
development
of
engineered
nanomaterials
(ENMs)
causes
humans
to
become
increasingly
exposed
them.
Therefore,
a
better
understanding
the
health
impact
ENMs
is
highly
demanded.
Considering
3Rs
(Replacement,
Reduction,
and
Refinement)
principle,
in
vitro
computational
methods
are
excellent
alternatives
for
testing
on
animals.
Among
methods,
nano‐quantitative
structure‐activity
relationship
(nano‐QSAR),
which
links
physicochemical
structural
properties
EMNs
with
biological
activities,
one
leading
method.
nature
toxicological
experiments
has
evolved
over
last
decades;
currently,
experiment
can
provide
thousands
measurements
organism's
functioning
at
molecular
level.
At
same
time,
capacity
systems
mimic
human
organism
also
improving
significantly.
Hence,
authors
would
like
discuss
whether
nano‐QSAR
approach
follows
modern
studies
takes
full
advantage
opportunities
offered
by
platforms.
Challenges
possibilities
data
integration
underlined
narratively,
including
need
consensus
built
between
QSAR
domains.
ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 30, 2025
Cuproptosis
exhibits
enormous
application
prospects
in
treatment.
However,
cuproptosis-based
therapy
is
impeded
by
the
limited
intracellular
copper
ions,
nonspecific
delivery,
uncontrollable
release,
and
chelation
of
endogenous
overproduced
glutathione
(GSH).
In
this
work,
an
ultrasound-triggered
nanosonosensitizer
(p-TiO2–Cu(I))
was
constructed
for
Cu(I)
on-demand
GSH
consumption,
deeper
tissue
response.
When
nanomedicine
internalized
into
tumor
cells,
ultrasound
(US)
induced
to
produce
reactive
oxygen
species
(ROS)
achieve
sonodynamic
(SDT).
GSH,
acting
as
a
hole
trapping
agent,
improved
efficiency
SDT.
Meanwhile,
downgrade
beneficial
cuproptosis
oxidative
damage-based
SDT
return.
What
more,
US
could
regulate
release
behavior
Cu(I).
bonded
mitochondrial
proteins
then
aggregated
lipoylated
protein,
bringing
about
turbulence
tricarboxylic
acid
cycle.
The
combination
showed
high
matching
induce
efficient
may
inspire
other
designs.
Pharmaceutics,
Год журнала:
2025,
Номер
17(4), С. 409 - 409
Опубликована: Март 25, 2025
Colorectal
cancer
poses
a
significant
threat
to
human
health
due
its
high
aggressiveness
and
poor
prognosis.
Key
factors
impacting
patient
outcomes
include
post-surgical
recurrence,
chemotherapeutic
drug
resistance,
insensitivity
immunotherapy.
Consequently,
early
diagnosis
the
development
of
effective
targeted
therapies
are
essential
for
improving
prevention
treatment
strategies.
Inorganic
nanomaterials
have
gained
prominence
in
colorectal
owing
their
unique
size,
advantageous
properties,
modifiability.
Various
types
inorganic
nanomaterials—such
as
metal-based,
metal
oxide,
quantum
dots,
magnetic
nanoparticles,
carbon-based,
rare-earth
nanomaterials—have
demonstrated
potential
enhancing
multimodal
imaging,
delivery,
synergistic
therapies.
These
advancements
underscore
critical
role
therapeutic
outcomes.
This
review
highlights
properties
nanomaterials,
summarizes
recent
applications
progress
treatment,
discusses
challenges
translating
these
materials
into
clinical
use.
It
aims
provide
valuable
insights
future
research
application
management.
