Experimental Neurology, Год журнала: 2024, Номер 381, С. 114942 - 114942
Опубликована: Авг. 31, 2024
Язык: Английский
Chemical Reviews, Год журнала: 2023, Номер 124(2), С. 554 - 628
Опубликована: Ноя. 22, 2023
In vivo imaging technologies have emerged as a powerful tool for both fundamental research and clinical practice. particular, luminescence in the tissue-transparent near-infrared (NIR, 700–1700 nm) region offers tremendous potential visualizing biological architectures pathophysiological events living subjects with deep tissue penetration high contrast owing to reduced light–tissue interactions of absorption, scattering, autofluorescence. The distinctive quantum effects nanocrystals been harnessed achieve exceptional photophysical properties, establishing them promising category luminescent probes. this comprehensive review, between light tissues, well advantages NIR imaging, are initially elaborated. Subsequently, we focus on achieving improved by optimizing performance nanocrystal fluorophores. ingenious design strategies probes discussed, along their respective biomedical applications versatile modalities. Finally, thought-provoking reflections challenges prospects future translation nanocrystal-based wisely provided.
Язык: Английский
Процитировано
74
Nature Reviews Materials, Год журнала: 2024, Номер 9(8), С. 567 - 588
Опубликована: Июнь 25, 2024
Язык: Английский
Процитировано
34
Pharmaceuticals, Год журнала: 2024, Номер 17(5), С. 612 - 612
Опубликована: Май 10, 2024
Overcoming the blood–brain barrier (BBB) remains a significant hurdle in effective drug delivery to brain. While BBB serves as crucial protective barrier, it poses challenges delivering therapeutic agents their intended targets within brain parenchyma. To enhance for treatment of neurological diseases, several technologies circumvent have been developed last few years. Among them, nanoparticles (NPs) are one most versatile and promising tools. Here, we summarize characteristics NPs that facilitate penetration, including size, shape, chemical composition, surface charge, importantly, conjugation with various biological or synthetic molecules such glucose, transferrin, insulin, polyethylene glycol, peptides, aptamers. Additionally, discuss coating surfactants. A comprehensive overview common vitro vivo models NP penetration studies is also provided. The discussion extends discussing impairment under pathological conditions leveraging alterations delivery. Emphasizing need future uncover inherent properties NPs, review advocates role beyond systems calls efforts translating clinic therapeutics. Overall, stand out highly strategy precise targeting disorders.
Язык: Английский
Процитировано
23
Nature Communications, Год журнала: 2025, Номер 16(1)
Опубликована: Фев. 6, 2025
The lysosome-targeting chimera (LYTAC) strategy provided a very powerful tool for the degradation of membrane proteins. However, synthesis LYTACs, antibody-small molecule conjugates, is challenging. ability antibody-based LYTACs to penetrate solid tumor limited as well, especially cross blood-brain barrier (BBB). Here, we propose covalent chimeric peptide-based targeted platform (Pep-TACs) by introducing long flexible aryl sulfonyl fluoride group, which allows proximity-enabled cross-linking upon binding with protein interest. Pep-TACs facilitates target proteins through mechanism recycling transferrin receptor (TFRC)-mediated lysosomal endocytosis. Biological experiments demonstrate that can significantly degrade expression PD-L1 on cells, dendritic cells and macrophages, under acidic conditions, markedly enhance function T phagocytosis macrophages. Furthermore, both in anti-PD-1-responsive -resistant models, exert significant anti-tumor immune response. It noteworthy BBB prolong survival mice situ brain tumor. As proof-of-concept, this study introduces modular TFRC-based peptide protein, immunotherapy tumors. LYTAC strategies often face challenges penetration synthesis. authors introduce Pep-TACs, effectively degrades PD-L1. This approach suppresses growth, particularly
Язык: Английский
Процитировано
9
Biomaterials, Год журнала: 2025, Номер 318, С. 123138 - 123138
Опубликована: Янв. 28, 2025
Язык: Английский
Процитировано
3
The Innovation, Год журнала: 2023, Номер 5(1), С. 100548 - 100548
Опубликована: Ноя. 27, 2023
•Micro/nanosystems show their potential to address the challenges of precise drug delivery brain.•Microfluidic platforms enable creation biomimetic in vitro brain models.•Micro/nano materials is emerging as a key player controllable delivery.•The minimally invasive fiberbot microsystem reduces procedure's invasiveness.•Image tracking micro/nanosystems allows for controlled therapeutic interventions. Drug crucial treatment central nervous system disorders. While significant progress has been made recent years, there are still major achieving brain. Unmet clinical needs arise from various factors, including transport, handling large doses, methods crossing biological barriers, use imaging guidance, and effective models analyzing delivery. Recent advances have shown promise addressing some these challenges. These include utilization microfluidic test validate process setting, development novel micro/nanocarriers loads across blood-brain barrier, implementation micro-intervention systems delivering drugs through intraparenchymal or peripheral routes. In this article, we present review latest developments We also delve into relevant diseases, conventional methods. addition, discuss future prospects robotic equipped with directed transportation, real-time image closed-loop control.
Язык: Английский
Процитировано
36
Expert Opinion on Drug Delivery, Год журнала: 2023, Номер 20(12), С. 1713 - 1730
Опубликована: Авг. 5, 2023
A major challenge in treating central nervous system (CNS) disorders is to achieve adequate drug delivery across the blood-brain barrier (BBB). Receptor-mediated nanodrug as a Trojan horse strategy has become an exciting approach. However, these nanodrugs do not accumulate significantly brain parenchyma, which greatly limits therapeutic effect of drugs. Amplifying efficiency receptor-mediated BBB becomes holy grail treatment CNS disorders.
Язык: Английский
Процитировано
24
Current Research in Biotechnology, Год журнала: 2024, Номер 8, С. 100235 - 100235
Опубликована: Янв. 1, 2024
Neuropharmacology faces challenges due to the intricate nervous system, diverse neurological disorders, and existence of blood–brain barrier (BBB), which hinder development effective treatments. Although primary function BBB is expel toxins pathogens, this structure also prevents optimal drug delivery. Natural products, with their chemical diversity sustainability, have long been recognized as potential neuroprotective compounds, making permeability studies mandatory. Over last ten years, biotechnological advances in two-dimensional vitro models (monoculture co-culture), vivo imaging techniques, pharmacokinetic modeling contributed expanding our current knowledge. In study, we reviewed crossing natural products such different terpenoids, polyphenolic alkaloids. The findings, obtained through vitro, vivo, silico methods, revealed moderate high for many these products. However, other compounds showed not be able reach brain. To better understand behavior humans improve ability pass across blood-brainier, new three-dimensional dynamic BBB, nanosystems complexes encapsulation or in-depth transport mechanism are future lines research.
Язык: Английский
Процитировано
14
Lab on a Chip, Год журнала: 2024, Номер 24(5), С. 1030 - 1063
Опубликована: Янв. 1, 2024
A great progress has been made in the development and use of lab-on-a-chip devices to model study blood–brain barrier (BBB) last decade.
Язык: Английский
Процитировано
12
European Polymer Journal, Год журнала: 2024, Номер 219, С. 113400 - 113400
Опубликована: Авг. 30, 2024
Язык: Английский
Процитировано
12