Biomimetic Gold Nanorods‐Manganese Porphyrins with Surface‐Enhanced Raman Scattering Effect for Photoacoustic Imaging‐Guided Photothermal/Photodynamic Therapy

Small, Год журнала: 2024, Номер 20(42)

Опубликована: Июнь 20, 2024

Abstract Surface‐enhanced Raman scattering (SERS) imaging integrating photothermal and photodynamic therapy (PTT/PDT) is a promising approach for achieving accurate diagnosis effective treatment of cancers. However, most available reporters show multiple signals in the fingerprint region, which overlap with background from cellular biomolecules. Herein, 4T1 cell membrane‐enveloped gold nanorods‐manganese porphyrins system (GMCMs) designed successfully fabricated as biomimetic theranostic nanoplatform. Manganese are adsorbed on surface Au nanorods via terminal alkynyl group. Cell membrane encapsulation protects manganese falling off nanorods. The GMCMs confirm specific homologous targeting to cells good dispersibility, excellent photoacoustic (PA) properties, preferable 1 O 2 generation performance. exhibit distinct SERS silent region without endogenous biomolecule interference both vitro vivo. ions could not only quench fluorescence enhance effect but also deplete GSH increase yield. Both vivo studies demonstrate that effectively eradicate tumors through SERS/PA imaging‐guided PTT/PDT. This study provides feasible strategy augmenting effects group GSH‐depletion PTT/PDT efficacy.

Язык: Английский

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Microenvironment‐Activatable Probe for Precise NIR‐II Monitoring and Synergistic Immunotherapy in Rheumatoid Arthritis

Advanced Materials, Год журнала: 2024, Номер 36(48)

Опубликована: Окт. 6, 2024

Rheumatoid arthritis (RA) represents an insidious autoimmune inflammatory disorder that severely lowers the life quality by progressively destructing joint functions and eventually causing permanent disability, posing a serious public health problem. Here, advanced theranostic probe is introduced integrates activatable second near-infrared (NIR-II) fluorescence imaging for precise RA diagnosis with multi-pronged treatments. A novel molecular comprising long-wavelength aggregation-induced emission unit manganese carbonyl cage motif synthesized, which enables NIR-II activation concurrently releasing therapeutic carbon monoxide (CO) gas in inflamed microenvironment. This self-assembles into biocompatible nanoprobe, subsequently conjugated anti-IL-6R antibody to afford active-targeting ability of RA. The nanoprobe exhibits significant turn-on signal at lesion, enabling highly sensitive real-time monitoring. combination ROS scavenging, on-demand CO release, IL-6 signaling blockade results potent effect synergistic immunomodulation impact, significantly alleviating symptoms preventing destruction. research introduces paradigm development high-performance, strategies facilitate detection enhanced treatment RA-related diseases.

Язык: Английский

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Brightness Strategies toward NIR-II Emissive Conjugated Materials: Molecular Design, Application, and Future Prospects

ACS Applied Bio Materials, Год журнала: 2024, Номер unknown

Опубликована: Апрель 1, 2024

Recent advances have been made in second near-infrared (NIR-II) fluorescence bioimaging and many related applications because of its advantages deep penetration, high resolution, minimal invasiveness, good dynamic visualization. To achieve high-performance NIR-II bioimaging, various materials probes with bright emission extensively explored the past few years. Among these emissive materials, conjugated polymers small molecules attracted wide interest due to their native biosafety tunable optical performance. This review summarizes brightness strategies available for highlights recent developments bioimaging. A concise, detailed overview molecular design regulatory approaches is provided terms brightness, long wavelengths, superior imaging Then, typical cases which are used as introduced by providing step-by-step examples. Finally, current problems challenges associated accessing briefly discussed, significance future prospects proposed offer helpful guidance development materials.

Язык: Английский

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Near–Infrared Heptamethine Cyanine Photosensitizers with Efficient Singlet Oxygen Generation for Anticancer Photodynamic Therapy

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(47)

Опубликована: Июль 31, 2024

Abstract Near‐infrared photosensitizers are valuable tools to improve treatment depth in photodynamic therapy (PDT). However, their low singlet oxygen ( 1 O 2 ) generation ability, indicated by quantum yield, presents a formidable challenge for PDT. To overcome this challenge, the heptamethine cyanine was decorated with biocompatible S Scy7 and Se Secy7 atom. We observe that exhibits redshift main absorption ~840 nm an ultra‐efficient capacity. The emergence of strong intramolecular charge transfer effect between atom polymethine chain considerably narrows energy gap (0.51 eV), heavy strengthens spin–orbit coupling (1.44 cm −1 ), both which greatly improved high triplet state yield (61 %), determines . Therefore, demonstrated excellent capacity, is ~24.5‐fold indocyanine green, ~8.2‐fold IR780, ~1.3‐fold methylene blue under low‐power‐density 850 irradiation (5 mW −2 ). considerable phototoxicity toward cancer cells buried 12 mm tissue. Nanoparticles formed encapsulating within amphiphilic polymers lecithin, promising antitumor anti‐pulmonary metastatic effects, exhibiting remarkable potential advancing PDT deep tissues.

Язык: Английский

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Neutrophil‐Targeting Semiconducting Polymer Nanotheranostics for NIR‐II Fluorescence Imaging‐Guided Photothermal‐NO‐Immunotherapy of Orthotopic Glioblastoma

Advanced Science, Год журнала: 2024, Номер 11(39)

Опубликована: Авг. 19, 2024

Abstract Glioblastoma (GBM) is one of the deadliest primary brain tumors, but its diagnosis and curative therapy still remain a big challenge. Herein, neutrophil‐targeting semiconducting polymer nanotheranostics (SSPN iNO ) reported for second near‐infrared (NIR‐II) fluorescence imaging‐guided trimodal orthotopic glioblastoma in mouse models. The SSPN are formed based on two polymers acting as NIR‐II probe well photothermal conversion agent, respectively. A thermal‐responsive nitric oxide (NO) donor an adenosine 2A receptor (A2AR) inhibitor co‐integrated into to enable therapeutic actions. surface attached with ligand mediate their effective delivery GBM sites via “Trojan Horse” manner, enabling high‐sensitive imaging. Upon light illumination, effectively generates heat effect, which not only kills tumor cells induces immunogenic cell death (ICD), also triggers controlled NO release strengthen ICD. Additionally, encapsulated A2AR can modulate immunosuppressive microenvironment by blocking adenosine‐A2AR pathway, further boosts antitumor immunological effect observably suppress progression. This study provide multifunctional theranostic nanoplatform cumulative actions treatment.

Язык: Английский

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A hypoxia-activated and microenvironment-remodeling nanoplatform for multifunctional imaging and potentiated immunotherapy of cancer

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Ноя. 29, 2024

Язык: Английский

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Semiconducting polymer dots for multifunctional integrated nanomedicine carriers

Materials Today Bio, Год журнала: 2024, Номер 26, С. 101028 - 101028

Опубликована: Март 24, 2024

The expansion applications of semiconducting polymer dots (Pdots) among optical nanomaterial field have long posed a challenge for researchers, promoting their intelligent application in multifunctional nano-imaging systems and integrated nanomedicine carriers diagnosis treatment. Despite notable progress, several inadequacies still persist the Pdots, including development simplified near-infrared (NIR) nanoprobes, elucidation inherent biological behavior, integration information processing nanotechnology into biomedical applications. This review aims to comprehensively elucidate current status Pdots as classical nanophotonic material by discussing its advantages limitations terms biocompatibility, adaptability microenvironments vivo, etc. Multifunctional surface chemistry play crucial roles realizing Pdots. Information visualization based on physicochemical properties is pivotal achieving detection, sensing, labeling probes. Therefore, we refined underlying mechanisms constructed multiple comprehensive original mechanism summaries establish benchmark. Additionally, explored cross-linking interactions between nanomedicine, potential yet complete metabolic pathways, future research directions, innovative solutions integrating treatment strategies. presents possible expectations valuable insights advancing specifically from chemical, medical, photophysical practitioners' standpoints.

Язык: Английский

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Cr-Free Bismuth-Based Persistent Luminescence Nanoparticle Composite for Cancer Theranostics

ACS Applied Nano Materials, Год журнала: 2024, Номер 7(15), С. 17759 - 17767

Опубликована: Июль 24, 2024

Near-infrared (NIR) persistent luminescence nanoparticles (PLNPs) showed great potential for bioimaging due to their integration of non-in situ excitation and deep tissue penetration. However, PLNPs are often introduced with Cr3+ ions as the NIR emission centers. Herein, we report Cr-free Bi2Ga3.985O9:1.5% Fe3+ (BGF), BGF under 310 nm exhibited afterglow at 794 in first biological imaging window (650–950 nm), duration 3 h. was grafted hydroxyl groups then polydopamine (PDA) indocyanine green (ICG) through π–π stacking hydrophobic interactions, PLNP–PDA–ICG composite. Bi composite, a heavy atom element, exhibits computed tomography (CT) contrast capacity, while PDA is photothermal agent, ICG excited produce reactive oxide species photodynamic therapy. The afterglow/CT dual-modality imaging-guided photothermal/photodynamic combination therapy validated vitro/vivo therapeutic applications. This work provides PLNP composite drug-free theranostics low toxicity.

Язык: Английский

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Integration of Functional Materials in Photonic and Optoelectronic Technologies for Advanced Medical Diagnostics

Biosensors, Год журнала: 2025, Номер 15(1), С. 38 - 38

Опубликована: Янв. 10, 2025

Integrating functional materials with photonic and optoelectronic technologies has revolutionized medical diagnostics, enhancing imaging sensing capabilities. This review provides a comprehensive overview of recent innovations in materials, such as quantum dots, perovskites, plasmonic nanomaterials, organic semiconductors, which have been instrumental the development diagnostic devices characterized by high sensitivity, specificity, resolution. Their unique optical properties enable real-time monitoring biological processes, advancing early disease detection personalized treatment. However, challenges material stability, reproducibility, scalability, environmental sustainability remain critical barriers to their clinical translation. Breakthroughs green synthesis, continuous flow production, advanced surface engineering are addressing these limitations, paving way for next-generation tools. article highlights transformative potential interdisciplinary research overcoming emphasizes importance sustainable scalable strategies harnessing diagnostics. The ultimate goal is inspire further innovation field, enabling creation practical, cost-effective, environmentally friendly solutions.

Язык: Английский

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Renal-Clearable Biomass-Derived Carbon Dots with Red Fluorescence for Masked Cryptic Kidney Injury Imaging

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 16, 2025

Masked cryptic kidney injury (MCKI), an early stage of acute (AKI), is challenging to detect and diagnose, especially in the modern context where toxic substances, such as surfactants, are increasingly misused. Consequently, there urgent need for methods visual diagnosis MCKI. In this study, we synthesized environmentally friendly spirulina-derived carbon dots (SpiCDs) using spirulina a biobased raw material through simple hydrothermal process. These SpiCDs, with their ultrasmall size, enable efficient renal clearance. cellular experiments, SpiCDs rapidly entered SDS-damaged cells, facilitating dynamic monitoring cell membrane damage vivo animal experiments demonstrated that were efficiently excreted kidneys began accumulate bladder within 10 min after tail vein injection. The detection red fluorescence urine confirmed metabolic pathway SpiCDs. Furthermore, MCKI model induced by SDS, showed accelerated excretion earlier accumulation bladder, indicating increased sensitivity injury. results suggest provide promising approach MCKI, offering insights into its monitoring.

Язык: Английский

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