Revolutionizing biomedicine: advancements, applications, and prospects of nanocomposite macromolecular carbohydrate-based hydrogel biomaterials: a review

RSC Advances, Год журнала: 2023, Номер 13(50), С. 35251 - 35291

Опубликована: Янв. 1, 2023

Nanocomposite hydrogel biomaterials represent an exciting frontier in biomedicine, offering solutions to longstanding challenges.

Язык: Английский

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Applications of neuro-computing and fractional calculus to blood streaming conveying modified trihybrid nanoparticles with interfacial nanolayer aspect inside a diseased ciliated artery under electroosmotic and Lorentz forces

International Communications in Heat and Mass Transfer, Год журнала: 2024, Номер 152, С. 107313 - 107313

Опубликована: Фев. 21, 2024

Язык: Английский

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Interactions between nanoparticles and lymphatic systems: Mechanisms and applications in drug delivery

Advanced Drug Delivery Reviews, Год журнала: 2024, Номер 209, С. 115304 - 115304

Опубликована: Апрель 9, 2024

Язык: Английский

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Trends in nanobody radiotheranostics

European Journal of Nuclear Medicine and Molecular Imaging, Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

Язык: Английский

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Zwitterionic Poly(ethylene glycol) Nanoparticles Minimize Protein Adsorption and Immunogenicity for Improved Biological Fate

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Янв. 17, 2025

We report the assembly of poly(ethylene glycol) nanoparticles (PEG NPs) and optimize their surface chemistry to minimize formation protein coronas immunogenicity for improved biodistribution. PEG NPs cross-linked with disulfide bonds are synthesized utilizing zeolitic imidazolate framework-8 as templates, which subsequently modified molecules different end groups (carboxyl, methoxy, or amino) vary chemistry. Among modifications, amino residual carboxyl form a pair zwitterionic structures on NPs, adsorption proteins (e.g., immunoglobulin, complement proteins) maximize blood circulation time. The influence preexisting antibodies in mice pharmacokinetics is negligible, demonstrates resistance anti-PEG inhibition accelerated clearance phenomenon. This research highlights importance PEGylated design delivery systems reveals translational potential cancer therapy.

Язык: Английский

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Liposomes as Immunotherapeutic Carriers: A Game-Changer in Cancer Therapy

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106847 - 106847

Опубликована: Март 1, 2025

Язык: Английский

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Targeted Liposomal Drug Delivery: Overview of the Current Applications and Challenges

Life, Год журнала: 2024, Номер 14(6), С. 672 - 672

Опубликована: Май 24, 2024

In drug development, it is not uncommon that an active substance exhibits efficacy in vitro but lacks the ability to specifically reach its target vivo. As a result, targeted delivery has become primary focus pharmaceutical sciences. Since approval of Doxil® 1995, liposomes have emerged as leading nanoparticle delivery. Their low immunogenicity, high versatility, and well-documented led their clinical use against wide variety diseases. That being said, every disease accompanied by unique set physiological conditions, each liposomal product must be formulated with this consideration. There are multitude different targeting techniques for can employed depending on application. Passive such PEGylation or enhanced permeation retention effect improve general pharmacokinetics, while conjugating molecules liposome surface may bring even further specificity. This review aims summarize current strategies treatment

Язык: Английский

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Toward the scale-up production of polymeric nanotherapeutics for cancer clinical trials

Nano Today, Год журнала: 2024, Номер 56, С. 102314 - 102314

Опубликована: Май 18, 2024

Язык: Английский

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Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives

CNS Neuroscience & Therapeutics, Год журнала: 2024, Номер 30(5)

Опубликована: Май 1, 2024

Abstract Gliomas are the most common primary tumors of central nervous system, with glioblastoma multiforme (GBM) having highest incidence, and their therapeutic efficacy depends primarily on extent surgical resection postoperative chemotherapy. The role intracranial blood–brain barrier occurrence drug‐resistant gene O6‐methylguanine‐DNA methyltransferase have greatly limited chemotherapeutic agents in patients GBM made it difficult to achieve expected clinical response. In recent years, rapid development nanotechnology has brought new hope for treatment tumors. Nanoparticles (NPs) shown great potential tumor therapy due unique properties such as light, heat, electromagnetic effects, passive targeting. Furthermore, NPs can effectively load drugs, significantly reduce side effects improve efficacy, showing chemotherapy glioma. this article, we reviewed mechanisms glioma drug resistance, physicochemical NPs, advances resistance. We aimed provide perspectives

Язык: Английский

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Role of PEGylated lipid in lipid nanoparticle formulation for in vitro and in vivo delivery of mRNA vaccines

Journal of Controlled Release, Год журнала: 2025, Номер 380, С. 108 - 124

Опубликована: Фев. 5, 2025

Язык: Английский

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