Talanta, Год журнала: 2024, Номер 280, С. 126709 - 126709
Опубликована: Авг. 13, 2024
Язык: Английский
Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 203, С. 115115 - 115115
Опубликована: Окт. 14, 2023
Silica nanoparticles (SNP) have gained tremendous attention in the recent decades. They been used many different biomedical fields including diagnosis, biosensing and drug delivery. Medical uses of SNP for anti-cancer, anti-microbial theranostic applications are especially prominent due to their exceptional performance deliver small molecules recently biologics (mRNA, siRNA, antigens, antibodies, proteins, peptides) at targeted sites. The physical chemical properties such as large specific surface area, tuneable particle size porosity, excellent biodegradability biocompatibility make them an ideal delivery diagnostic platform. Based on available data pre-clinical SNP, interest has driven these innovative materials towards clinical application with formulations already Phase I II trials. Herein, progress field is reviewed, safety aspects analysed. Importantly, we critically evaluate key structural characteristics overcome biological barriers blood-brain barrier (BBB), skin, tumour mucosal barrier. Future directions, potential pathways, target areas rapid translation also recommended.
Язык: Английский
Процитировано
81
Chemical Reviews, Год журнала: 2024, Номер 124(13), С. 8307 - 8472
Опубликована: Июнь 26, 2024
Due to the intrinsic non-invasive nature, cost-effectiveness, high safety, and real-time capabilities, besides diagnostic imaging, ultrasound as a typical mechanical wave has been extensively developed physical tool for versatile biomedical applications. Especially, prosperity of nanotechnology nanomedicine invigorates landscape ultrasound-based medicine. The unprecedented surge in research enthusiasm dedicated efforts have led mass multifunctional micro-/nanosystems being applied biomedicine, facilitating precise diagnosis, effective treatment, personalized theranostics. deployment applications is rooted profound understanding relationship among composition, structure, property, bioactivity, application, performance. In this comprehensive review, we elaborate on general principles regarding design, synthesis, functionalization, optimization abundant particular, recent advancements imaging are meticulously summarized. Furthermore, systematically elucidate state-of-the-art studies concerning progress therapeutic targeting various pathological abnormalities including cancer, bacterial infection, brain diseases, cardiovascular metabolic diseases. Finally, conclude provide an outlook field with in-depth discussion challenges faced future developments further extensive clinical translation application.
Язык: Английский
Процитировано
33
ACS Nano, Год журнала: 2024, Номер 18(20), С. 12716 - 12736
Опубликована: Май 8, 2024
Mesoporous silica nanoparticles (MSNs) represent a promising avenue for targeted brain tumor therapy. However, the blood–brain barrier (BBB) often presents formidable obstacle to efficient drug delivery. This study introduces ligand-free PEGylated MSN variant (RMSN25-PEG-TA) with 25 nm size and slight positive charge, which exhibits superior BBB penetration. Utilizing two-photon imaging, RMSN25-PEG-TA particles remained in circulation over 24 h, indicating significant traversal beyond cerebrovascular realm. Importantly, DOX@RMSN25-PEG-TA, our loaded doxorubicin (DOX), harnessed enhanced permeability retention (EPR) effect achieve 6-fold increase accumulation compared free DOX. In vivo evaluations confirmed potent inhibition of orthotopic glioma growth by extending survival rates spontaneous models 28% offering an improved biosafety profile. Advanced LC-MS/MS investigations unveiled distinctive protein corona surrounding RMSN25-PEG-TA, suggesting proteins such as apolipoprotein E albumin could play pivotal roles enabling its Our results underscore potential MSNs treating tumors, supports development future drug–nanoparticle design paradigms.
Язык: Английский
Процитировано
22
Pharmaceuticals, Год журнала: 2024, Номер 17(1), С. 126 - 126
Опубликована: Янв. 18, 2024
Resveratrol is a polyphenolic compound that has gained considerable attention in the past decade due to its multifaceted therapeutic potential, including anti-inflammatory and anticancer properties. However, efficacy impeded by low water solubility, dose-limiting toxicity, bioavailability, rapid hepatic metabolism. To overcome these hurdles, various nanoparticles such as organic inorganic nanoparticles, liposomes, polymeric dendrimers, solid lipid gold zinc oxide zeolitic imidazolate frameworks, carbon nanotubes, bioactive glass mesoporous were employed deliver resveratrol, enhancing against types of cancer. Resveratrol-loaded nanoparticle or resveratrol-conjugated administration exhibits excellent potency compared free resveratrol. This review highlights latest developments nanoparticle-based delivery systems for focusing on potential limitations associated with compound’s bioavailability effectiveness.
Язык: Английский
Процитировано
21
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 7547 - 7566
Опубликована: Июль 1, 2024
Abstract: Cancer poses a significant threat to human life and health. Chemotherapy is currently one of the effective cancer treatments, but many chemotherapy drugs have cell toxicity, low solubility, poor stability, narrow therapeutic window, unfavorable pharmacokinetic properties. To solve above problems, target drug delivery tumor cells, reduce side effects drugs, an anti-tumor system based on microenvironment has become focus research in recent years. The construction reduction-sensitive nanomedicine disulfide bonds attracted much attention. Disulfide good reductive responsiveness can effectively high glutathione (GSH) levels environment, enabling precise delivery. further enhance targeting accelerate release, are often combined with pH-responsive nanocarriers highly expressed ligands cells construct systems. connect molecules polymer system, as well between different carrier molecules. This article summarized systems (DDS) that researchers constructed years bond microenvironment, cleavage-triggering conditions, various loading strategies, design. In this review, we also discuss controlled release mechanisms these DDS clinical applicability challenges faced translation. Keywords: bond, systems, GSH/ROS
Язык: Английский
Процитировано
18
Molecules, Год журнала: 2025, Номер 30(3), С. 542 - 542
Опубликована: Янв. 24, 2025
The CRISPR-Cas9 technology, one of the groundbreaking genome editing methods for addressing genetic disorders, has emerged as a powerful, precise, and efficient tool. However, its clinical translation remains hindered by challenges in delivery efficiency targeting specificity. This review provides comprehensive analysis structural features, advantages, potential applications various non-viral stimuli-responsive systems, examining recent progress to emphasize address these limitations advance therapeutics. We describe how reports that nonviral vectors, including lipid-based nanoparticles, extracellular vesicles, polymeric gold mesoporous silica can offer diverse advantages enhance stability, cellular uptake, biocompatibility, based on their structures physio-chemical stability. also summarize nanoformulations, type vector, introduce precision control delivery. Stimuli-responsive nanoformulations are designed respond pH, redox states, external triggers, facilitate controlled targeted delivery, minimize off-target effects. insights our suggest future gene therapy technologies highlight systems CRISPR-Cas9’s efficacy, positioning them pivotal tools gene-editing therapies.
Язык: Английский
Процитировано
2
Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер unknown, С. 114534 - 114534
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
2
ACS Nano, Год журнала: 2023, Номер 17(17), С. 16308 - 16325
Опубликована: Авг. 29, 2023
Owing to their uniform and tunable particle size, pore shape, along with modular surface chemistry biocompatibility, mesoporous silica nanoparticles (MSNs) have found extensive applications as nanocarriers deliver therapeutic, diagnostic combined "theranostic" cargos cells tissues. Although thoroughly investigated, MSN garnered FDA approval for only one system via oral administration. One possible reason is that there no recognized, reproducible, widely adopted synthetic protocol, meaning not all MSNs are created equal in the laboratory nor eyes of FDA. This manuscript provides sol-gel research communities a fully characterized protocol synthesize corresponding lipid-coated delivery vehicles predetermined drug loading release characteristics. By carefully articulating step-by-step procedures highlighting critical points troubleshooting, augmented videos schematics, this Article will help researchers entering rapidly expanding field yield reliable results.
Язык: Английский
Процитировано
32
RSC Advances, Год журнала: 2024, Номер 14(20), С. 14017 - 14040
Опубликована: Янв. 1, 2024
Nanotechnology revolutionizes breast cancer treatment by improving drug delivery, overcoming barriers, and reducing side effects. This review highlights its potential superiority over conventional methods, transforming management.
Язык: Английский
Процитировано
13
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Июнь 20, 2024
Abstract Novel therapeutic strategies against difficult-to-treat bacterial infections are desperately needed, and the faster cheaper way to get them might be by repurposing existing antibiotics. Nanodelivery systems enhance efficacy of antibiotics guiding their targets, increasing local concentration at site infection. While recently described nanodelivery promising, they generally not easy adapt different lack biocompatibility or specificity. Here, created that source targeting proteins from bacteriophages. Bacteriophage receptor-binding cell-wall binding domains conjugated nanoparticles, for targeted delivery rifampicin, imipenem, ampicillin pathogens. They show excellent specificity accumulate infection deliver antibiotic payload. Moreover, suppress pathogen more effectively than 16 32-fold higher doses free This study demonstrates bacteriophage sourced promising candidates guide systems. Their specificity, availability, make great options needed combat infections.
Язык: Английский
Процитировано
12