Comprehensive Review of Mesoporous Silica Nanoparticles: Drug Loading, Release, and Applications as Hemostatic Agents

ChemistrySelect, Год журнала: 2024, Номер 9(23)

Опубликована: Июнь 18, 2024

Abstract Recently, mesoporous silica nanoparticles (MSNs) have emerged as promising candidates in the field of hemorrhage control owing to their extended pore size, high surface area, and excellent biocompatibility. These characteristics directly influence toxicity cells, loading therapeutic agents, release active ions during hemostasis process. Therefore, understanding fundamentals tuning these is important design types carriers. While several literature reviews explored role MSNs control, comprehensive studies focusing on general specific applications remain scarce. This review concentrates principles synthesizing silica, MSNs, techniques for drugs methods onto site injury, kinetics models, biocompatibility, toxicity, unique properties MSNs. Furthermore, article examines mechanism action nanomaterial hemostatic agents.

Язык: Английский

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Receptor Ligand-Free Mesoporous Silica Nanoparticles: A Streamlined Strategy for Targeted Drug Delivery across the Blood–Brain Barrier

ACS Nano, Год журнала: 2024, Номер 18(20), С. 12716 - 12736

Опубликована: Май 8, 2024

Mesoporous silica nanoparticles (MSNs) represent a promising avenue for targeted brain tumor therapy. However, the blood–brain barrier (BBB) often presents formidable obstacle to efficient drug delivery. This study introduces ligand-free PEGylated MSN variant (RMSN25-PEG-TA) with 25 nm size and slight positive charge, which exhibits superior BBB penetration. Utilizing two-photon imaging, RMSN25-PEG-TA particles remained in circulation over 24 h, indicating significant traversal beyond cerebrovascular realm. Importantly, DOX@RMSN25-PEG-TA, our loaded doxorubicin (DOX), harnessed enhanced permeability retention (EPR) effect achieve 6-fold increase accumulation compared free DOX. In vivo evaluations confirmed potent inhibition of orthotopic glioma growth by extending survival rates spontaneous models 28% offering an improved biosafety profile. Advanced LC-MS/MS investigations unveiled distinctive protein corona surrounding RMSN25-PEG-TA, suggesting proteins such as apolipoprotein E albumin could play pivotal roles enabling its Our results underscore potential MSNs treating tumors, supports development future drug–nanoparticle design paradigms.

Язык: Английский

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Hollow mesoporous silica nanoparticles for drug formulation and delivery: opportunities for cancer therapy

Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер unknown, С. 114534 - 114534

Опубликована: Янв. 1, 2025

Язык: Английский

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Lipid nanoparticles for RNA delivery: Self-assembling vs driven-assembling strategies

Advanced Drug Delivery Reviews, Год журнала: 2024, Номер 208, С. 115291 - 115291

Опубликована: Март 19, 2024

Among non-viral vectors, lipid nanovectors are considered the gold standard for delivery of RNA therapeutics. The success nanoparticles delivery, with three products approved human use, has stimulated further investigation into therapeutics different pathologies. This requires decoding pathological intracellular processes and tailoring system to target tissue cells. complexity morphology originates from assembling lipidic components, which can be elicited by various methods able drive formation desired organization. In other cases, pre-formed mixed induce self-assembly structural reorganization RNA-loaded nanoparticles. this review, most relevant their potentialities described on basis mechanism particle architecture.

Язык: Английский

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Semiconductor Nanoplatelets Based Host‐Guest Assembly Structure with High Color Purity for Hue‐Recognizable Lateral Flow Immunoassay

Advanced Functional Materials, Год журнала: 2024, Номер 34(26)

Опубликована: Фев. 26, 2024

Abstract The hue‐recognition based point‐of‐care diagnosis favorites both human visual perception and imaging analysis with portable terminals. Semiconductor nanoplatelets (NPLs) as an emerging narrow‐emissive fluorophore particularly suit above color‐purity desired diagnosis, but are hindered by their intrinsic hydrophobicity difficulty in controlled assembly. Here the host‐guest assembling of hydrophobic NPLs developed within 3D porous space dendritic templates, stepwise surface silanization to fabricate silica‐NPLs‐silica structure (SNS). enables high fluorescence single assembly reaching 246‐fold 4‐fold brightness NPL commercial europium‐doped polystyrene bead. strategy is compatible various colored (≈540–640 nm emission) provides stable aqueous colloids well‐preserved emission. narrow emission SNS enable signal amplification visual/image color discrimination. hue‐recognizable lateral flow immunoassay for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) nucleocapsid protein reveals average naked‐eye interpretation accuracy 92.9% over six concentration levels referring standard card, accompanied a quantification linear range 0.13–200 ng mL −1 limit detection 0.13 smartphone. diagnostic results SARS‐CoV‐2 positive clinical samples demonstrate easily distinguishable antigen on hue‐gradients, which holds significance home‐based self‐testing pathogens.

Язык: Английский

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Custom‐Design of Multi‐Stimuli‐Responsive Degradable Silica Nanoparticles for Advanced Cancer‐Specific Chemotherapy

Small, Год журнала: 2024, Номер 20(35)

Опубликована: Апрель 23, 2024

Chemotherapy is crucial in oncology for combating malignant tumors but often encounters obatacles such as severe adverse effects, drug resistance, and biocompatibility issues. The advantages of degradable silica nanoparticles tumor diagnosis treatment lie their ability to target delivery, minimizing toxicity normal tissues while enhancing therapeutic efficacy. Moreover, responsiveness both endogenous exogenous stimuli opens up new possibilities integrating multiple modalities. This review scrutinizes the burgeoning utility combination with chemotherapy other Commencing elucidation synthesis degradation mechanisms, emphasis placed on these materials (e.g., pH, redox reactions, hypoxia, enzymes) light high-intensity focused ultrasound). this exploration delves into strategies harnessing alone, coupled radiotherapy, photothermal therapy, photodynamic gas immunotherapy, starvation chemodynamic elucidating multimodal synergies. Concluding an assessment advances, challenges, constraints oncology, despite hurdles, future investigations are anticipated augment role cancer therapy. These insights can serve a compass devising more efficacious combined strategies.

Язык: Английский

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Nanomaterial-Driven Precision Immunomodulation: A New Paradigm in Therapeutic Interventions

Cancers, Год журнала: 2024, Номер 16(11), С. 2030 - 2030

Опубликована: Май 27, 2024

Immunotherapy is a rapidly advancing field of research in the treatment conditions such as cancer and autoimmunity. Nanomaterials can be designed for immune system manipulation, with precise targeted delivery improved immunomodulatory efficacy. Here, we elaborate on various strategies using nanomaterials, including liposomes, polymers, inorganic NPs, discuss their detailed design intricacies, mechanisms, applications, current regulatory issues. This type nanomaterial targeting specific cells or tissues controlling release kinetics could push technological frontiers provide new innovative solutions immune-related disorders diseases without off-target effects. These materials enable interactions cells, thereby enhancing effectiveness checkpoint inhibitors, vaccines, adoptive cell therapies. Moreover, they allow fine-tuning responses while minimizing side At intersection nanotechnology immunology, nanomaterial-based platforms have immense potential to revolutionize patient-centered immunotherapy reshape disease management. By prioritizing safety, customization, compliance standards, these systems make significant contributions precision medicine, significantly impacting healthcare landscape.

Язык: Английский

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Development of PLGA-SPC3 functionalized Gefitinib mesoporous silica nano-scaffolds for breast cancer targeting: Biodistribution and Cytotoxicity analysis

Pharmaceutical Development and Technology, Год журнала: 2025, Номер unknown, С. 1 - 26

Опубликована: Янв. 31, 2025

The exploration of novel carriers for cancer treatments is on the rise, as drugs are often hindered by ineffective delivery to tumor site. In present study, Mesoporous silica nano scaffolds were developed heat assisted hydrolysis (HAH) technique, and functionalized using PLGA. These further loaded with nanosized Gefitinib (GTB). surface properties MSNs (GTB-PEG-PLGA-MSN) enhanced SPC3. characterized pore volume, particle size, zeta potential (ZP), area, entrapment efficiency (%EE), drug content.The invitro release kinetics, cytotoxicity analysis invivo biodistribution studies performed in optimized MSN Albino Wistar rats. result shows an increase %EE, loading MSN. vitro F5-GTB-PEG-PLGA-SPC3-MSN demonstrated a higher antitumor activity (43.84 ± 0.63%, p<0.05) comparison free drug. A accumulation GTB was detected liver (29,415 126 ng) indicating significant (p > 0.05). MCF-7 cell line signify viability demonstrating its efficacy breast cancer. Optimized offers improved cellular uptake, suppression less toxicity. To conclude, HAH technique produced stable MSNs, PLGA-SPC3 could be ideal carrier delivery.

Язык: Английский

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Landscape of small nucleic acid therapeutics: moving from the bench to the clinic as next-generation medicines

Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)

Опубликована: Март 10, 2025

Abstract The ability of small nucleic acids to modulate gene expression via a range processes has been widely explored. Compared with conventional treatments, acid therapeutics have the potential achieve long-lasting or even curative effects editing. As result recent technological advances, efficient delivery for therapeutic and biomedical applications achieved, accelerating their clinical translation. Here, we review increasing number classes most common chemical modifications platforms. We also discuss key advances in design, development application each platform. Furthermore, this presents comprehensive profiles currently approved drugs, including 11 antisense oligonucleotides (ASOs), 2 aptamers 6 siRNA summarizing modifications, disease-specific mechanisms action strategies. Other candidates whose trial status recorded updated are discussed. consider strategic issues such as important safety considerations, novel vectors hurdles translating academic breakthroughs clinic. Small produced favorable results trials address previously “undruggable” targets, suggesting that they could be useful guiding additional candidates.

Язык: Английский

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The potential utility of dendritic fibrous nanosilica as an adsorbent and a catalyst in carbon capture, utilization, and storage

Chemical Society Reviews, Год журнала: 2024, Номер 53(20), С. 9976 - 10011

Опубликована: Янв. 1, 2024

Dendritic fibrous nanosilica (DFNS) is one of the most promising materials for carbon capture, utilization, and storage (CCUS) applications with tunable activity selectivity.

Язык: Английский

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