Fertility and Sterility, Год журнала: 2024, Номер 122(1), С. 6 - 11
Опубликована: Март 5, 2024
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(3), С. 2995 - 2995
Опубликована: Фев. 3, 2023
Recent studies have demonstrated that the uterus has its own microbiota. However, there is no consensus on endometrial microbiota composition, thus role in healthy uterine environment still a frontier topic. Endometrial receptivity key to embryo implantation, and this specific context immunological tolerance against fetal antigens tightly regulated expression of inflammatory mediators are fundamental. According recent evidence, may interact very dynamic way with immune system during peri-conceptional stage later pregnancy. For reason, condition dysbiosis might lead adverse pregnancy outcomes. The aim review summarize evidence molecular mechanisms by which system. purpose, link between reproductive disorders, such as infertility, recurrent loss (RPL), preterm birth, will be discussed. In conclusion, most findings from analyses reported illustrate possibly overcome intrinsic limitations detection (low biomass, high risk contamination sampling, lack standardization).
Язык: Английский
Процитировано
32
International Journal of Gynecology & Obstetrics, Год журнала: 2023, Номер 162(S2), С. 29 - 42
Опубликована: Авг. 1, 2023
Abstract Abnormal uterine bleeding (AUB) is common, often debilitating, and may affect over 50% of reproductive‐aged women girls. Whereas AUB a collection symptoms that include intermenstrual abnormalities in period duration, cycle length, regularity, it heavy menstrual (HMB) most contributory to iron deficiency related anemia. It apparent AUB, general, HMB, particular, remain underrecognized underreported. FIGO created two systems for assessing classifying AUB. System 1 defines the pattern using four primary descriptors: frequency, flow volume. 2 provides structured classification system possible causes acronym PALM‐COEIN. “PALM” refers structural (Polyp, Adenomyosis, Leiomyoma, Malignancy), “COEI” nonstructural (Coagulopathy, Ovulatory dysfunction, Endometrial, Iatrogenic). The “N” reserved those entities are currently not otherwise classified. Using as gateway streamlines investigation girls with Understanding pathogenesis “PALM‐COEIN” helps interpret investigations onward management Numerous evidence gaps exist concerning AUB; however, if researchers trialists universally adopt Systems assessment diagnosis clear translatable research findings can be applied globally.
Язык: Английский
Процитировано
29
Fertility and Sterility, Год журнала: 2024, Номер 122(1), С. 20 - 30
Опубликована: Май 8, 2024
Uterine fibroids (UFs) are the most common female benign pelvic tumors, affecting >60% of patients aged 30-44 years. asymptomatic in a large percentage cases and may be identified incidentally using transvaginal ultrasound or magnetic resonance imaging scan. However, approximately 30% cases, UFs affect quality life women's health, with abnormal uterine bleeding heavy menstrual being complaints, along iron deficiency (ID) ID anemia. Medical treatments used for UFs-related include symptomatic agents, such as nonsteroidal antiinflammatory drugs tranexamic acid, hormonal therapies, including combined oral contraceptives, gonadotropin-releasing hormone agonists antagonists, levonorgestrel intrauterine systems, selective progesterone receptor modulators, aromatase inhibitors. Nevertheless, few approved specifically UF treatment, them manage symptoms. Surgical options fertility-sparing treatments, myomectomy, nonconservative options, hysterectomy, especially perimenopausal women who not responding to any treatment. Radiologic interventions also available: artery embolization, high-intensity focused resonance-guided ultrasound, radiofrequency ablation. Furthermore, management anemia, consequence acute chronic bleeding, should taken into account use replacement therapy both during medical treatment before after surgical procedure. In case UFs, location, size, multiple coexistent adenomyosis guide choice shared decision-making process, considering long- short-term goals expected by patient, pregnancy desire wish preserve uterus independently reproductive goals.
Язык: Английский
Процитировано
13
Fertility and Sterility, Год журнала: 2024, Номер 122(1), С. 31 - 39
Опубликована: Март 5, 2024
Язык: Английский
Процитировано
10
Reproductive Health, Год журнала: 2024, Номер 21(1)
Опубликована: Фев. 19, 2024
Abstract Objective To examine the prevalence of menstrual pain among women reproductive age and its impact on their daily lives professional responsibilities. Methods A cross-sectional descriptive study was conducted in July August 2022. Phone interviews were carried out using a random system to select aged between 15 49 years old. The questionnaire included sociodemographic variables, contraception method used, characteristics pattern (pain bleeding amount), influence working life, if they would need resort sick leaves due impairments arising from symptoms. Results total 1800 representative Spanish population took part this study. 72.6% them report pain, with 45.9% requiring medication. 35.9% identify as intense or very intense. 38.8% assert that discomforts affect everyday life. 34.3% have required not attending work activities having requested leave discomforts, although only 17.3% finally so, mainly because 58.4% considered it might imply consequences environment, especially those Higher Education. who more discomfort are youngest ones condoms contraceptive (p < 0.001). Conclusions Menstrual is prevalent problem can life some occasions.
Язык: Английский
Процитировано
9
BJOG An International Journal of Obstetrics & Gynaecology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 25, 2025
To assess the association between menstrual disorders and workforce participation among Australian women. Population-based cohort study. Secondary analysis of eight surveys collected 2000 2021. A total 11 152 women, born 1973 1978. Between 2021, self-reported longitudinal survey data were collected. At each survey, measured. Data analysed using generalised estimating equations for multinomial responses, with stratification by age. Workforce participation. Women who often experienced premenstrual tension reported lower odds working part-time compared to full-time work (Adjusted Odds Ratio (AOR) = 0.74; 95% CI: 0.61, 0.90), this finding strongest women aged 31 40 (AOR 0.68, 0.59, 0.78). While overall, irregular periods had higher 1.32, 1.08, 1.61), 22 30 0.39, 0.97). severe period pain being unemployed 1.18; 1.01, 1.36), in 41 older 1.19, 1.40). There is substantial variation participation, role women's ages these associations. Increased awareness further elucidation factors may improve engagement workforce.
Язык: Английский
Процитировано
1
Frontiers in Global Women s Health, Год журнала: 2022, Номер 3
Опубликована: Фев. 14, 2022
The purpose of this study was 2-fold, to (1) explore current education provision in UK schools including barriers menstrual cycle and (2) assess the perceived support teachers received deliver education. Seven hundred eighty-nine (91% female) from all stages school England (48%), Scotland (24%), Wales (22%) Northern Ireland (6%) completed an online survey. survey captured information on schools, teacher's knowledge confidence cycle, provided teachers, products impact young people school. Four ninety-eight reported lessons were (63%), predominantly delivered within personal, social, health economic or science subjects, with over half focusing biology (56%) (40%) rather than lived experiences (14%). Teachers affected participation PE (88%), pupil attendance (82%) attitude behavior (82%). Overall, 80% felt receiving training would be beneficial improve results highlight is scientifically focused, less management symptoms experiences. also perceive influence multiple aspects personal performance. There a need address across help empower girls manage their preventing negative
Язык: Английский
Процитировано
29
Endocrines, Год журнала: 2022, Номер 3(1), С. 127 - 138
Опубликована: Март 16, 2022
Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) encompass a variety of symptoms that occur during the luteal phase menstrual cycle impair daily life activities relationships. Depending on type severity physical, emotional or behavioral symptoms, women reproductive age followed for at least two prospective cycles may receive one diagnoses. PMDD is most severe form PMS, predominantly characterized by not due to another psychiatric disorder. PMS are common neuro-hormonal gynecological disorders with multifaceted etiology. Gonadal steroid hormones their metabolites influence plethora biological systems involved in occurrence specific but there no doubt PMS/PMDD centrally based disorders. A more sensitive neuroendocrine threshold cyclical variations estrogens progesterone under physiological hormonal therapies present. Moreover, altered brain sensitivity allopregnanolone, metabolite produced after ovulation potentiating GABA activity, along an impairment opioid serotoninergic systems, justify symptoms. Even neuro-inflammation expressed via GABAergic system investigation as etiological factor PMS/PMDD. Pharmacological management aims stabilize fluctuations restore balance. The rationale suppressing supports prescription combined contraception (CHC). Its effect mood highly variable depends biochemical characteristics exogenous steroids Hormonal regimens reducing estrogen-free interval menstruation seem better choices. Psychoactive agents, such serotonin reuptake inhibitors (SSRIs), effective be prescribed continuously only phase. Novel therapeutic approaches include inhibition receptors brain, i.e., ulipristal acetate, reduced conversion dutasteride, modulation action allopregnanolone sepranolone.
Язык: Английский
Процитировано
29
Expert Review of Hematology, Год журнала: 2023, Номер 16(sup1), С. 71 - 86
Опубликована: Март 15, 2023
Background People who have or had the potential to menstruate (PPM) with inherited bleeding disorders (BD) face particular challenges receiving appropriate diagnosis and care participating in research. As part of an initiative create a National Research Blueprint for future decades research, Hemophilia Foundation (NHF) American Thrombosis Hemostasis Network conducted extensive all-stakeholder consultations identify priorities PPM BDs those them.Research design methods Working group (WG) 4 NHF State Science Summit distilled community-identified into concrete research questions scored their feasibility, impact, risk.Results WG4 identified important gaps foundational knowledge upon which base optimal BDs. They defined 44 top-priority concerning lifespan sex biology, pregnancy post-partum context, uterine physiology bleeding, bone joint health, health delivery, patient-reported outcomes quality-of-life.Conclusions The needs will best be advanced designed across spectrum gender methodologies outcome measures tailored this population, involving them throughout.
Язык: Английский
Процитировано
19
Vaccine, Год журнала: 2023, Номер 41(29), С. 4327 - 4334
Опубликована: Июнь 1, 2023
Язык: Английский
Процитировано
19