Immunological Reviews,
Год журнала:
2022,
Номер
309(1), С. 86 - 89
Опубликована: Июнь 20, 2022
Abstract
After
more
than
20
years
of
studying
sex
differences
in
viral
pathogenesis
and
immunity
to
vaccines,
the
COVID‐19
pandemic
provided
me
with
a
unique
opportunity
raise
awareness
about
biological
differences.
The
scientific
community
public,
alike,
embraced
clinical
epidemiological
data
supported
inquiries
into
how
males
are
twice
as
likely
be
hospitalized
die
from
COVID‐19.
Immunological
changes
associated
pregnancy
also
contribute
worse
outcomes
Collectively,
we
finding
that
inflammation
is
critical
mediator
for
pregnant
females.
gave
platform
discuss
address
on
bigger
stage,
but
two
decades
studies
working
other
viruses
prepared
this
moment
history.
Gynecologic and Obstetric Investigation,
Год журнала:
2022,
Номер
87(3-4), С. 219 - 225
Опубликована: Янв. 1, 2022
SARS-CoV-2
infection
triggers
a
significant
maternal
inflammatory
response.
There
is
dearth
of
information
regarding
whether
at
admission
for
delivery
or
vaccination
an
response
in
the
fetus.
This
study
aims
evaluating
fetal
to
compared
control
group.
Design,
Participants,
Setting,
and
Methods:
A
prospective
cohort
was
performed
with
total
61
pregnant
women
who
presented
single
medical
center
(William
Beaumont
Hospital,
Royal
Oak,
MI).
All
mothers
were
tested
using
polymerase
chain
reaction
(PCR)
on
labor
unit.
Three
groups
evaluated:
22
positive
test
(case
group),
23
negative
(control
16
had
recent
SAR-CoV-2
(vaccine
group).
At
delivery,
cord
blood
collected
determine
levels
IL-6,
C-reactive
protein
(CRP),
nucleocapsid
IgG
IgM
antibodies.
In
all
cases,
newborn
PCR
showed
no
clinical
findings
consistent
infection.Mean
(SD)
IL-6
level
not
significantly
different
three
groups:
case
group
9.00
±
3.340
pg/mL,
5.19
0.759
vaccine
7.11
2.468
pg/mL
(p
value
0.855).
Pairwise
comparison
also
revealed
statistical
difference
concentrations
p
values
versus
control,
vaccine,
=
0.57,
0.91,
0.74,
respectively.
Similarly,
there
statistically
frequency
elevated
(>11
pg/mL)
between
0.89).
CRP
across
0.634).
among
different.
12
out
samples
group,
2
(indicating
old
resolved
infection),
0
group.A
number
enrolled
which
represents
relatively
small
patients.
Most
patients
mainly
asymptomatic.
addition,
our
received
mRNA-based
vaccines
(mRNA1273
BNT162b2).
We
did
other
vaccines.In
cohort,
neither
nor
indicated
increased
inflammation
newborns
SARS-CoV-2-infected
vaccinated
mothers.
American Journal of Reproductive Immunology,
Год журнала:
2023,
Номер
89(4)
Опубликована: Янв. 21, 2023
It
is
now
recognized
that
SARS-CoV-2
infection
and
pandemic-related
stress
impacts
maternal
health.
However,
their
effects
at
the
maternal-fetal
interface
are
still
debated.We
recruited
199
women
between
March
2020
July
2021,
79
SARS-CoV-2+
120
negative
(the
latter
exposed
to
pandemic
only).
We
also
included
40
historic
controls
(i.e.
pre-pandemic
uncomplicated
pregnancies
before
2020).
Placental
samples
were
collected
for
protein
histological
analysis.The
majority
of
multiethnic,
had
higher
pre-pregnancy
BMI
elevated
preterm
birth
rate
(17%)
vs
SARS-CoV-2-
or
control.
inflammatory
profile
revealed
increased
IL-1Ra
CRP,
independently
status,
whilst
MCP-1,
IL-6
IFNγ
in
negative,
but
stress-exposed,
group.
These
changes
predominant
placentas
with
lesions
on
histopathological
analysis.
Furthermore,
we
observed
immune
cells
(CD45+)
from
controls,
even
when
individuals
pregnancy
complications
excluded.Placental
profiles
differed
statuses,
namely
+/-
infection.
This
highlights
need
understand
differences
added
burden
placental
Clinical Case Reports,
Год журнала:
2022,
Номер
10(2)
Опубликована: Фев. 1, 2022
Pregnancy
might
impact
immunity
after
SARS-CoV-2
infection
and/or
vaccination.
We
describe
the
first
case
of
reinfection
with
during
a
pregnancy.
While
mother
lacked
detectable
antibodies
2
months
infection,
both
and
baby
had
IgG
at
delivery.
Infection
did
not
cause
any
adverse
pregnancy
outcome.
Immunological Reviews,
Год журнала:
2022,
Номер
309(1), С. 86 - 89
Опубликована: Июнь 20, 2022
Abstract
After
more
than
20
years
of
studying
sex
differences
in
viral
pathogenesis
and
immunity
to
vaccines,
the
COVID‐19
pandemic
provided
me
with
a
unique
opportunity
raise
awareness
about
biological
differences.
The
scientific
community
public,
alike,
embraced
clinical
epidemiological
data
supported
inquiries
into
how
males
are
twice
as
likely
be
hospitalized
die
from
COVID‐19.
Immunological
changes
associated
pregnancy
also
contribute
worse
outcomes
Collectively,
we
finding
that
inflammation
is
critical
mediator
for
pregnant
females.
gave
platform
discuss
address
on
bigger
stage,
but
two
decades
studies
working
other
viruses
prepared
this
moment
history.
