Asian Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер unknown, С. 101011 - 101011
Опубликована: Дек. 1, 2024
Язык: Английский
Asian Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 19(3), С. 100911 - 100911
Опубликована: Апрель 14, 2024
Precision therapy has become the preferred choice attributed to optimal drug concentration in target sites, increased therapeutic efficacy, and reduced adverse effects. Over past few years, sprayable or injectable thermosensitive hydrogels have exhibited high potential. These can be applied as cell-growing scaffolds drug-releasing reservoirs by simply mixing a free-flowing sol phase at room temperature. Inspired their unique properties, been widely delivery treatment platforms for precision medicine. In this review, state-of-the-art developments are investigated, which covers from thermo-gelling mechanisms main components biomedical applications, including wound healing, anti-tumor activity, osteogenesis, periodontal, sinonasal ophthalmic diseases. The most promising applications trends of also discussed light features.
Язык: Английский
Процитировано
10
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140902 - 140902
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1
International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 137708 - 137708
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
6
Pharmaceutics, Год журнала: 2024, Номер 16(8), С. 969 - 969
Опубликована: Июль 23, 2024
Lung cancer is the leading cause of cancer-related mortality worldwide, largely due to limited efficacy anticancer drugs, which primarily attributed insufficient doses reaching lungs. Additionally, patients undergoing treatment experience severe systemic adverse effects distribution drugs non-targeted sites. In light these challenges, there has been a growing interest in pulmonary administration for lung cancer. This route allows be delivered directly lungs, resulting high local concentrations that can enhance antitumor while mitigating toxic effects. However, poses challenge overcoming mechanical, chemical, and immunological defenses respiratory tract prevent inhaled drug from properly penetrating To overcome drawbacks, use nanoparticles inhaler formulations may promising strategy. Nanoparticles assist minimizing clearance, increasing penetration into epithelium, enhancing cellular uptake. They also facilitate increased stability, promote controlled release, delivery target sites, such as tumor environment. Among them, chitosan-based demonstrate advantages over other polymeric nanocarriers their unique biological properties, including activity mucoadhesive capacity. These properties have potential when administered via route. view above, this paper provides an overview research conducted on drug-loaded incorporated devices Furthermore, article addresses emerging technologies, siRNA (small interfering RNA), context therapy. Particularly, recent studies employing are described.
Язык: Английский
Процитировано
5
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(1), С. 658 - 658
Опубликована: Янв. 4, 2024
High-throughput genetic screening is useful for discovering critical genes or gene sequences that trigger specific cell functions and/or phenotypes. Loss-of-function mainly achieved through RNA interference (RNAi), CRISPR knock-out (CRISPRko), and (CRISPRi) technologies. Gain-of-function depends on the overexpression of a cDNA library activation (CRISPRa). Base editing can perform both gain- loss-of-function screening. This review discusses techniques based Cas9 nuclease, including Cas9-mediated genome dCas9-based interference. We compare these methods with previous RNAi propose future prospects applications
Язык: Английский
Процитировано
4
Journal of drug targeting, Год журнала: 2025, Номер unknown, С. 1 - 43
Опубликована: Фев. 19, 2025
In the dynamic arena of cancer therapeutics, chemoimmunotherapy has shown tremendous promise, especially for aggressive forms breast like triple-negative (TNBC). This review delves into significant role liposomes in enhancing effectiveness by leveraging cancer-specific mechanisms such as induction immunogenic cell death (ICD), reprogramming tumor microenvironment (TME), and enabling sequential drug release. We examine innovative dual-targeting that capitalize on heterogeneity, well pH-sensitive formulations offer improved control over delivery. Unlike prior analyses, this directly links advancements preclinical research-such PAMAM dendrimer-based nanoplatforms RGD-decorated liposomes-to clinical trial results, highlighting their potential to revolutionize TNBC treatment strategies. Additionally, we address ongoing challenges related scalability, toxicity, regulatory compliance, propose future directions personalized, immune-focused nanomedicine. work not only synthesizes latest research but also offers a framework translating liposomal from laboratory practice.
Язык: Английский
Процитировано
0
International Journal of Pharmaceutics, Год журнала: 2024, Номер 662, С. 124403 - 124403
Опубликована: Июнь 28, 2024
Язык: Английский
Процитировано
3
Advanced Science, Год журнала: 2024, Номер 11(41)
Опубликована: Сен. 9, 2024
Abstract The programmed death 1 (PD‐1)/programmed ligand (PD‐L1) axis inhibits T cell activity, impairing anti‐tumor immunity. Blocking this with therapeutic antibodies is one of the most promising immunotherapies. It has long been recognized that PD‐1/PD‐L1 blockade reinvigorates exhausted (T EX ) cells already present in tumor microenvironment (TME). However, recent advancements high‐throughput gene sequencing and bioinformatic tools have provided researchers a more granular dynamic insight into blockade‐responding cells, extending beyond TME populations. This review provides an update on identity, spatial distribution, treatment‐induced spatiotemporal dynamics responders. also synopsis preliminary reports potential responders other than to depict panoramic picture. Important questions answer further studies translational clinical evolving understandings are discussed.
Язык: Английский
Процитировано
3
Nano Today, Год журнала: 2024, Номер 57, С. 102328 - 102328
Опубликована: Июнь 14, 2024
Язык: Английский
Процитировано
2
ACS Nano, Год журнала: 2024, Номер 18(28), С. 18230 - 18245
Опубликована: Июль 1, 2024
Therapy-induced modulation of the tumor microenvironment (TME) to overcome immunosuppressive TME is considered be an opportunity for cancer treatment. However, monitoring during therapeutic process accurately determine immune responses and adjust treatment plans in a timely manner remains challenging. Herein, we report carrier-free nanotheranostic system (CANPs) assembled by two boron dipyrromethene (BODIPY) dyes, sonophotosensitizer C-BDP, nitric oxide (NO) probe amino-BODIPY (A-BDP). CANPs can exert combined sonophototherapeutic effects C-BDP under ultrasound light irradiation simultaneously induce inflammatory TME, as well emit bright fluorescence via A-BDP tumor-associated macrophages (TAMs) repolarization through released NO vitro vivo. Of note, transforming growth factor-β (TGF-β) could key cytokine involved sonophototherapy-induced reprogramming. By virtue high physiological stability, good biocompatibility, effective targetability, potential simultaneous induction detection reprogramming triggered sonophototherapy.
Язык: Английский
Процитировано
2