Prolonged exposure to lung-derived cytokines is associated with inflammatory activation of microglia in patients with COVID-19 DOI Creative Commons
Rogan A. Grant, Taylor A. Poor, Lango Sichizya

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Июль 28, 2023

Neurological impairment is the most common finding in patients with post-acute sequelae of COVID-19. Furthermore, survivors pneumonia from any cause have an elevated risk dementia

Язык: Английский

Cardiovascular autonomic dysfunction in post-COVID-19 syndrome: a major health-care burden DOI
Artur Fedorowski,

Alessandra Fanciulli,

Satish R. Raj

и другие.

Nature Reviews Cardiology, Год журнала: 2024, Номер 21(6), С. 379 - 395

Опубликована: Янв. 2, 2024

Язык: Английский

Процитировано

54
Long COVID Definitions and Models of Care DOI
Roger Chou,

Eric Herman,

Azrah Y. Ahmed

и другие.

Annals of Internal Medicine, Год журнала: 2024, Номер 177(7), С. 929 - 940

Опубликована: Май 20, 2024

Definitions of long COVID are evolving, and optimal models care uncertain.

Язык: Английский

Процитировано

22
Differentiation of Prior SARS-CoV-2 Infection and Postacute Sequelae by Standard Clinical Laboratory Measurements in the RECOVER Cohort DOI
Kristine M. Erlandson, Linda N. Geng, Caitlin Selvaggi

и другие.

Annals of Internal Medicine, Год журнала: 2024, Номер 177(9), С. 1209 - 1221

Опубликована: Авг. 12, 2024

There are currently no validated clinical biomarkers of postacute sequelae SARS-CoV-2 infection (PASC).

Язык: Английский

Процитировано

14
Prolonged exposure to lung-derived cytokines is associated with activation of microglia in patients with COVID-19 DOI Creative Commons
Rogan A. Grant, Taylor A. Poor, Lango Sichizya

и другие.

JCI Insight, Год журнала: 2024, Номер unknown

Опубликована: Март 19, 2024

BACKGROUNDSurvivors of pneumonia, including SARS-CoV-2 are at increased risk for cognitive dysfunction and dementia. In rodent models, following pneumonia has been linked to the systemic release lung-derived pro-inflammatory cytokines. Microglia poised respond inflammatory signals from circulation, their impairment in murine models dementia humans.METHODSWe measured levels 55 cytokines chemokines bronchoalveolar lavage fluid plasma 341 patients with respiratory failure 13 healthy controls, 93 unvaccinated COVID-19 203 other causes pneumonia. We used flow cytometry sort neuroimmune cells postmortem brain tissue 5 who died 3 single-cell RNA-sequencing.RESULTSMicroglia exhibited a transcriptomic signature suggestive activation by circulating Peak were similar irrespective etiology, but cumulative cytokine exposure was higher COVID-19. Treatment corticosteroids reduced expression COVID-19-specific cytokines.CONCLUSIONProlonged lung inflammation results sustained elevations compared those secondary pathogens. exhibit transcriptional responses These findings support data causally linking further investigation into role microglia pneumonia-related dysfunction.FUNDINGSCRIPT U19AI135964, UL1TR001422, P01AG049665, P01HL154998, R01HL149883, R01LM013337, R01HL153122, R01HL147290, R01HL147575, R01HL158139, R01ES034350, R01ES027574, I01CX001777, U01TR003528, R21AG075423, T32AG020506, F31AG071225, T32HL076139.

Язык: Английский

Процитировано

12
How to understand the overlap of long COVID, chronic fatigue syndrome/myalgic encephalomyelitis, fibromyalgia and irritable bowel syndromes DOI
Don L. Goldenberg

Seminars in Arthritis and Rheumatism, Год журнала: 2024, Номер 67, С. 152455 - 152455

Опубликована: Май 7, 2024

Язык: Английский

Процитировано

9
A comparative cohort study of post-COVID-19 conditions based on physical examination records in China DOI Creative Commons
Zhong Liu,

Boqiang Hu,

Tao Zeng

и другие.

EBioMedicine, Год журнала: 2025, Номер 112, С. 105549 - 105549

Опубликована: Янв. 5, 2025

Язык: Английский

Процитировано

1
Wait Time to See a Neurologist After Referral Among Medicare Participants DOI
Chun Chieh Lin, Lavanya Muthukumar, Evan L. Reynolds

и другие.

Neurology, Год журнала: 2025, Номер 104(3)

Опубликована: Янв. 8, 2025

Timely access to specialist care is crucial in expeditious diagnosis and treatment. Our study aimed assess the time patients wait from being referred by a physician seeing neurologist using Medicare data. Specifically, we evaluated differences related sex, race/ethnicity, geography, availability of neurologists. We conducted cross-sectional analysis 2018-2019 sample who had new patient visit neurologist. primary outcome was between their last with referring first (the index visit). also looked at for neurologic condition that same condition. used linear mixed-effects model identify factors associated time, considering patients' hospital referral regions (HRRs). identified 163,313 beneficiaries after them. Their average age 73.8 (SD 10.7). The median (interquartile range) 34 days (15-70), 18% waited >90 days. Patients multiple sclerosis (MS) an 29.4 longer, epilepsy 10.4 Parkinson disease (PD) 9.3 longer than back pain. There were no significant times across race/ethnicity sex. showed varying levels availability. When visited located outside residential or physician's HRR, extended 11 found that, see them while more 90 Factors such as did not significantly affect timely MS, epilepsy, PD times, despite needing specialized neurologists can provide. This highlights need innovative approaches improve

Язык: Английский

Процитировано

1
Neurologic Manifestations of Long COVID Disproportionately Affect Young and Middle‐Age Adults DOI Creative Commons
Natasha A. Choudhury,

Shreya Mukherjee,

Tracey Singer

и другие.

Annals of Neurology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 22, 2024

Objective To investigate neurologic manifestations of post‐acute sequelae SARS‐CoV‐2 infection (Neuro‐PASC) in post‐hospitalization Neuro‐PASC (PNP) and non‐hospitalized (NNP) patients across the adult lifespan. Methods Cross‐sectional study first consecutive 200 PNP 1,100 NNP evaluated at a Neuro‐coronavirus disease 2019 (COVID‐19) clinic between May 2020 March 2023. Patients were divided into younger (18–44 years), middle‐age (45–64 older (65+ years) age groups. Results Younger individuals accounted for 142 (71%) 995 1100 (90.5%) patients. Significant age‐related differences frequencies comorbidities abnormal findings demonstrated higher prevalence Conversely, 10 months from COVID‐19 onset, we found significant symptoms indicating lower prevalence, therefore, symptom burden, individuals. Moreover, there subjective impression fatigue (median [interquartile range (IQR)] patient‐reported outcomes measurement information system [PROMIS] score: 64 [57–69], 63 [57–68], 60.5 [50.8–68.3]; p = 0.04) sleep disturbance [IQR] PROMIS 57 [51–63], 56 [53–63], 54 [46.8–58]; 0.002) group, commensurate with impairment quality life (QoL) among Finally, objective executive function National Institutes Health [NIH] toolbox 48 [35–63], 49 [38–63], 54.5 [45–66.3]; 0.01), working memory NIH 47 [40–53], 50 [44–57], [43–58]; 0.0002) patients, worst performance coming group. Interpretation are disproportionally affected by regardless acute severity. Although people more frequently have comorbidities, suffer burden cognitive dysfunction contributing to decreased QoL. principally affects adults their prime, profound public health socioeconomic impacts warranting dedicated resources prevention, diagnosis interventions. ANN NEUROL 2024

Язык: Английский

Процитировано

7
Profibrotic monocyte-derived alveolar macrophages are expanded in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19 DOI Creative Commons
Joseph I. Bailey, Connor Puritz, Karolina J. Senkow

и другие.

Nature Immunology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 4, 2024

Язык: Английский

Процитировано

6
Plasma proteomics show altered inflammatory and mitochondrial proteins in patients with neurologic symptoms of post-acute sequelae of SARS-CoV-2 infection DOI

Barbara A. Hanson,

Lavanya Visvabharathy, Zachary S. Orban

и другие.

Brain Behavior and Immunity, Год журнала: 2023, Номер 114, С. 462 - 474

Опубликована: Сен. 11, 2023

Язык: Английский

Процитировано

15