What do we know about nutrient-based strategies targeting molecular mechanisms associated with obesity-related fatty liver disease?

Annals of Hepatology, Год журнала: 2022, Номер 28(1), С. 100874 - 100874

Опубликована: Ноя. 10, 2022

Obesity is a risk factor for developing nonalcoholic fatty liver disease (NAFLD), and the associated molecular mechanisms could be targeted with nutrient-based strategies. Therefore, it necessary to review current propose further treatments. facilitates onset of insulin resistance, lipidic abnormalities, hepatic fat accumulation, lipid peroxidation, mitochondrial dysfunction, excessive reactive oxygen species (ROS) production, inflammation, all related steatosis progression fibrosis. Microbiota alterations can also influence by translocation pathogenic bacteria, energy extraction from short chain acids (SCFAs), intestinal suppression expression fasting-induced adipose (FIAF), reduction bile acids, altered choline metabolism. There are genetic polymorphisms in metabolic proteins that predispose higher diseases, such as those found patatin-like phospholipase domain-containing 3 (PNPLA3), transmembrane 6 superfamily member 2 (TM6SF2), membrane-bound O-acyltransferase 7 (MBOAT7) or known lysophosphatidylinositol acyltransferase 1 (LPIAT1), channel-like 4 genes (TMC4), mass obesity-associated protein (FTO), b Klotho (KLB) carboxylesterase (CES1). No clear dietary guidelines target NAFLD development progression. However, carbohydrate intake restriction, regular physical exercise, supplementation antioxidants, restoration gut microbiota seem have beneficial effects on new proposed features NAFLD.

Язык: Английский

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Phenotypes of non-alcoholic fatty liver disease (NAFLD) and all-cause mortality: unsupervised machine learning analysis of NHANES III

BMJ Open, Год журнала: 2022, Номер 12(11), С. e067203 - e067203

Опубликована: Ноя. 1, 2022

Objectives Non-alcoholic fatty liver disease (NAFLD) is a non-communicable with rising prevalence worldwide and large burden for patients health systems. To date, the presence of unique phenotypes in NAFLD has not been studied, their identification could inform precision medicine public pragmatic implications personalised management care NAFLD. Design Cross-sectional prospective (up to 31 December 2019) analysis National Health Nutrition Examination Survey III (1988–1994). Primary secondary outcomes measures diagnosis was based on ultrasound. The following predictors informed an unsupervised machine learning algorithm (k-means): body mass index, waist circumference, systolic blood pressure (SBP), plasma glucose, total cholesterol, triglycerides, enzymes alanine aminotransferase, aspartate aminotransferase gamma glutamyl transferase. We summarised (means) compared across clusters. used Cox proportional hazard models quantify all-cause mortality risk associated each cluster. Results 1652 (mean age 47.2 years 51.5% women) were grouped into 3 clusters: anthro-SBP-glucose (6.36%; highest levels anthropometrics, SBP glucose), lipid-liver (10.35%; lipid enzymes) average (83.29%; at levels). Compared phenotype, phenotype had higher (aHR=2.88; 95% CI: 2.26 3.67); (aHR=1.11; 0.86 1.42). Conclusions There heterogeneity NAFLD, whom can be divided three different risk. These guide specific interventions plans, thus advancing

Язык: Английский

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Metabolic dysfunction associated steatotic liver disease in resource-limited settings

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 167 - 175

Опубликована: Фев. 15, 2024

Язык: Английский

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Curcumin nanoemulsions on the expression of fatty acid transporter proteins during hepatic steatosis

Опубликована: Фев. 19, 2024

Introduction Fructose intake of over 70 g/day is known to cause dyslipidemias, involving multiple metabolic pathways that can promote an excess hepatic lipid synthesis as dysfunction-associated fatty liver disease (MAFLD), formerly non-alcoholic disease.

Язык: Английский

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MBOAT7 rs641738 Variant Is Not Associated with an Increased Risk of Hepatocellular Carcinoma in a Latin American Cohort

Digestive Diseases and Sciences, Год журнала: 2023, Номер 68(11), С. 4212 - 4220

Опубликована: Сен. 8, 2023

The rs641738 C > T single-nucleotide polymorphism of MBOAT7 has been associated with hepatocellular carcinoma (HCC) and nonalcoholic fatty liver disease (NAFLD). Latin Americans have high rates HCC NAFLD, but no assessment between performed in this population. We provide the first impact on risk Americans. Patients were prospectively recruited into ESCALON network, designed to collect samples from American patients 6 South countries (Argentina, Ecuador, Brazil, Chile, Peru, Colombia). A European cohort general Hispanic population gnomAD database included for comparison. Associations evaluated using logistic regression. In total, 310 cases 493 cirrhosis without assessed. TT genotype was not predictive (TT vs CC OR adjusted = 1.15, 95% CI 0.66–2.01, p 0.610) or Europeans 1.20, 0.59–2.43, 0.621). No significant association noted subgroup analysis viral hepatitis, alcohol-related disease. increased NAFLD-cirrhosis compared a non-cirrhotic NAFLD + CT 2.75, 1.10–6.87, 0.031). rs631738 allele Europeans. An increase NAFLD.

Язык: Английский

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