Biosensors and Bioelectronics, Год журнала: 2020, Номер 173, С. 112787 - 112787
Опубликована: Ноя. 6, 2020
Язык: Английский
Nano Convergence, Год журнала: 2021, Номер 8(1)
Опубликована: Ноя. 2, 2021
Modern medicine has been waging a war on cancer for nearly century with no tangible end in sight. Cancer treatments have significantly progressed, but the need to increase specificity and decrease systemic toxicities remains. Early diagnosis holds key improving prognostic outlook patient quality of life, diagnostic tools are cusp technological revolution. Nanotechnology steadily expanded into reaches chemotherapy, radiotherapy, diagnostics, imaging, demonstrating capacity augment each advance care. Nanomaterials provide an abundance versatility, functionality, applications engineer specifically targeted medicine, accurate early-detection devices, robust imaging modalities, enhanced radiotherapy adjuvants. This review provides insights current clinical pre-clinical nanotechnological drug therapy, radiation therapy.
Язык: Английский
Процитировано
181
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Год журнала: 2020, Номер 13(2)
Опубликована: Сен. 19, 2020
Dendritic polymers have highly branched three-dimensional architectures, the fourth type apart from linear, cross-linked, and one. They possess not only a large number of terminal functional units interior cavities, but also low viscosity with weak or no entanglement. These features endow them great potential in various biomedicine applications, including drug delivery, gene therapy, tissue engineering, immunoassay bioimaging. Most review articles related to bio-related applications dendritic focus on their while very few are devoted function as cancer diagnosis agents, which essential for treatment. In this review, we will provide comprehensive insights into polymer-based agents. Their classification preparation presented readers precise understanding polymers. On account physical/chemical properties biological cancer, suggest design strategies constructing such active passive targeting strategies, imaging reporters-incorporating and/or internal stimuli-responsive degradable/enhanced strategies. recent vitro cells exosomes vivo primary metastasis tumor sites aid single/multiple modalities be discussed detail. This article is categorized under: Therapeutic Approaches Drug Discovery > Nanomedicine Oncologic Disease Diagnostic Tools Nanodiagnostics Imaging Nanoparticle-Based Sensing.
Язык: Английский
Процитировано
171
Chemosensors, Год журнала: 2020, Номер 8(4), С. 117 - 117
Опубликована: Ноя. 20, 2020
Brain tumors, especially glioblastoma, remain the most aggressive form of all cancers because inefficient diagnosis and profiling. Nanostructures, such as metallic nanostructures, silica nano-vehicles, quantum dots, lipid nanoparticles (NPs) polymeric NPs, with high specificity have made it possible to permeate blood–brain barrier (BBB). NPs possess optical, magnetic photodynamic properties that can be exploited by surface modification, bio composition, contrast agents’ encapsulation coating tumor-derived cells. Hence, nanotechnology has brought on a revolution in field imaging brain tumors cancers. Recently, nanomaterials biomimetic functions been introduced efficiently cross BBB engulfed deep skin cancer malignancies for imaging. The review focuses nanotechnology-based diagnostic approaches exploration Moreover, also summarizes few strategies image glioblastoma multimodal functional nanocomposites more precise accurate clinical diagnosis. Their unique physicochemical attributes, including nanoscale sizes, larger area, explicit structural features ability encapsulate diverse molecules their surface, render nanostructured materials excellent nano-vehicles convey drug target region. This sheds light current progress various kinds nanomaterials, liposomes, nano-micelles, dendrimers, carbon nanotubes, dots (gold, silver zinc oxide NPs), efficient delivery treatment cancer.
Язык: Английский
Процитировано
139
Progress in Materials Science, Год журнала: 2022, Номер 125, С. 100919 - 100919
Опубликована: Янв. 4, 2022
Язык: Английский
Процитировано
94
International Journal of Nanomedicine, Год журнала: 2021, Номер Volume 16, С. 5955 - 5980
Опубликована: Авг. 1, 2021
Two-dimensional nanomaterials are emerging as promising candidates for a wide range of biomedical applications including tissue engineering, biosensing, pathogen incapacitation, wound healing, and gene drug delivery. Graphene, due to its high surface area, photothermal property, loading capacity, efficient cellular uptake, is at the forefront these materials plays key role in this multidisciplinary research field. Poor water dispersibility low functionality graphene, however, hamper hybridization into new nanostructures future nanomedicine. Functionalization either by covalent or non-covalent methods, most useful strategy improve dispersion well processability devices. In review, recent advances functionalization graphene derivatives different (macro)molecules reported explained. particular, hydrophilic oxide (GO) their physicochemical properties discussed. We have focused on anticancer delivery polyfunctional sheets.
Язык: Английский
Процитировано
66
ACS Nano, Год журнала: 2023, Номер 17(9), С. 8053 - 8063
Опубликована: Апрель 24, 2023
Gadolinium chelates for tumor magnetic resonance imaging (MRI) face challenges such as inadequate sensitivity, lack of selectivity, and risk Gd leakage. This study presents a single-atom nano-contrast agent (Gd-SA) that enhances MRI. Isolated atoms coordinated by six N two O are atomically dispersed on hollow carbon nanosphere, allowing the maximum utilization with reduced toxic ion Owning to large surface area fast exchange relaxed water molecules, Gd-SA shows excellent T1-weighted enhancement r1 value 11.05 mM–1 s–1 at 7 T, which is 3.6 times commercial gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA). In vivo MRI results show has higher spatial resolution wider time window tumors than Gd-DTPA, low hematological, hepatic, nephric toxicities. These advantages demonstrate great potential Gd-based nanomaterials safe, efficient, long-term contrast agents cancer diagnosis.
Язык: Английский
Процитировано
27
Exploration, Год журнала: 2024, Номер 4(4)
Опубликована: Янв. 23, 2024
Self-assembled peptides have been among the important biomaterials due to its excellent biocompatibility and diverse functions. Over past decades, substantial progress breakthroughs made in designing self-assembled with multifaceted biomedical applications. The techniques for quantitative analysis, including imaging-based techniques, chromatographic technique computational approach (molecular dynamics simulation), are becoming powerful tools exploring structure, properties, applications, even supramolecular assembly processes of peptides. However, a comprehensive review concerning these remains scarce. In this review, recent investigation biostability, cellular uptake, biodistribution, self-assembly behaviors peptide etc., summarized. Specific applications roles highlighted detail. Finally, challenges outlook field concluded. It is believed that will provide technical guidance researchers peptide-based materials pharmaceuticals, facilitate related research newcomers field.
Язык: Английский
Процитировано
8
Applied Materials Today, Год журнала: 2024, Номер 37, С. 102087 - 102087
Опубликована: Фев. 16, 2024
Язык: Английский
Процитировано
8
ACS Applied Bio Materials, Год журнала: 2021, Номер 4(3), С. 2798 - 2809
Опубликована: Март 4, 2021
A single-atom metal doped on carbonaceous nanomaterials has attracted increasing attention due to its potential applications as high-performance catalysts. However, few studies focus the of such nanotheranostics for simultaneous bioimaging and cancer therapy. Herein, it is pioneeringly demonstrated that Gd anchored onto graphene quantum dots (SAGd-GQDs), with dendrite-like morphology, was successfully prepared. More importantly, as-fabricated SAGd-GQDs exhibits a robustly enhanced longitudinal relaxivity (r1 = 86.08 mM-1 s-1) at low Gd3+ concentration 2 μmol kg-1, which 25 times higher than commercial Gd-DTPA 3.44 s-1). In vitro in vivo suggest obtained highly potent contrast agent obtain high-definition MRI, thereby opening up more opportunities future precise clinical theranostics.
Язык: Английский
Процитировано
34
Journal of medical & health sciences review., Год журнала: 2025, Номер 2(1)
Опубликована: Янв. 16, 2025
In this study, we reported on the possibility of new material gadolinium-doped carbon nitride (Gd/g-C₃N₄) composite and last documented checks for its antimicrobial properties, antioxidant, biocompatibility. The Gd/g-C₃N₄ was prepared evaluated biotoxicity antioxidant activity, bacterial biofilm inhibition in “Escherichia coli” “Staphylococcus aureus”. Cytotoxicity profiles were further analyzed with help hemolysis assay as per results obtained, exerted mild eryptosis, 10.05% while g-C₃N₄-DMF, 4.78%. anti-radical activities predicted using DPPH assay; g-C₃N₄-DMF showed a higher percentage radical scavenging ability 48.09 % than 36.27 %. For antibacterial testing, potential to inhibit “E. “S. aureus” bio movie formation analyzed, it could be seen that developed significantly performed slightly better compared g-C₃N₄-DMF. These show possesses relatively satisfactory biological but biocompatibility performance should enhanced when applied disinfection antifouling coatings.
Язык: Английский
Процитировано
0