J — Multidisciplinary Scientific Journal,
Год журнала:
2024,
Номер
7(4), С. 584 - 591
Опубликована: Дек. 22, 2024
This
study
explored
a
novel
method
using
fructose-derived
carbon
dots
(FCDs)
for
antitumor
therapy
in
breast
cancer
(BC),
marking
pioneering
use
of
fructose
as
source
nanoparticle
synthesis.
BC,
known
its
complexity
and
heterogeneity,
was
chosen
model
due
to
increasing
mortality
incidence
rates.
The
FCD
synthesis
involved
the
decomposition
through
microwave
irradiation,
followed
by
purification
characterization
techniques
such
transmission
electron
microscopy,
dynamic
light
scattering,
fluorescence
spectrophotometry,
Fourier-transform
infrared
spectroscopy.
FCDs,
ranging
size
from
2
6
nm,
presented
hydrodynamic
diameter
below
spherical
morphology,
crystalline
structure.
As
expected,
FCDs
were
composed
carbon,
oxygen,
hydrogen,
exhibited
with
absorption
emission
spectra
at
405
nm
around
520
respectively.
Cell-based
assays
on
epithelial
tumor
cell
lines
demonstrated
dose-dependent
response,
decreased
viability
rate
more
pronounced
cells.
In
conclusion,
showed
significant
potential
selective
agents
therapy.
comprehensive
cell-based
assay
evaluations
provided
valuable
insights
into
applications
these
nanoparticles
treatment,
highlighting
their
toxicity
impact
ACS Pharmacology & Translational Science,
Год журнала:
2024,
Номер
7(4), С. 967 - 990
Опубликована: Март 19, 2024
Precision
medicine
is
transforming
colorectal
cancer
treatment
through
the
integration
of
advanced
technologies
and
biomarkers,
enhancing
personalized
effective
disease
management.
Identification
key
driver
mutations
molecular
profiling
have
deepened
our
comprehension
genetic
alterations
in
cancer,
facilitating
targeted
therapy
immunotherapy
selection.
Biomarkers
such
as
microsatellite
instability
(MSI)
DNA
mismatch
repair
deficiency
(dMMR)
guide
decisions,
opening
avenues
for
immunotherapy.
Emerging
liquid
biopsies,
artificial
intelligence,
machine
learning
promise
to
revolutionize
early
detection,
monitoring,
selection
precision
medicine.
Despite
these
advancements,
ethical
regulatory
challenges,
including
equitable
access
data
privacy,
emphasize
importance
responsible
implementation.
The
dynamic
nature
with
its
tumor
heterogeneity
clonal
evolution,
underscores
necessity
adaptive
strategies.
future
lies
potential
enhance
patient
care,
clinical
outcomes,
understanding
this
intricate
disease,
marked
by
ongoing
evolution
field.
current
reviews
focus
on
providing
in-depth
knowledge
various
diverse
approaches
utilized
against
at
both
biochemical
levels.
Abstract
Research
into
the
anticancer
activity
of
quantum-sized
carbon
dots
(CDs)
has
emerged
as
a
promising
avenue
in
cancer
research.
This
CDs
delves
opportunities
and
challenges
associated
with
harnessing
potential
these
nanostructures
for
combating
cancer.
Quantum-sized
dots,
owing
to
their
unique
physicochemical
properties,
exhibit
distinct
advantages
therapeutic
agents.
Opportunities
lie
tunable
size,
surface
functionalization
capabilities,
biocompatibility,
enabling
targeted
drug
delivery
imaging
cells.
However,
we
include
challenges,
comprehensive
understanding
underlying
mechanisms,
toxicity
concerns,
optimization
synthesis
methods
enhanced
efficacy.
A
succinct
summary
state
research
this
area
is
given
review,
emphasizing
exciting
possibilities
ongoing
utilizing
novel
strategy
treatment.
C – Journal of Carbon Research,
Год журнала:
2024,
Номер
10(3), С. 60 - 60
Опубликована: Июль 5, 2024
Carbon
dots
(CDs)
have
emerged
as
a
promising
class
of
carbon-based
nanomaterials
due
to
their
unique
properties
and
versatile
applications.
(CDs),
also
known
carbon
quantum
(CQDs)
or
graphene
(GQDs),
are
nanoscale
materials
with
dimensions
typically
less
than
10
nanometers.
They
exhibit
intriguing
optical,
electronic,
chemical
properties,
making
them
attractive
for
wide
range
applications,
including
sensing,
imaging,
catalysis,
energy
conversion,
among
many
others.
Both
bottom-up
top-down
synthesis
approaches
utilized
the
dots,
each
method
impacting
physicochemical
characteristics.
can
diverse
structures,
amorphous,
crystalline,
hybrid
depending
on
precursor
used.
CDs
structures
modified
oxygen,
polymer-based,
amino
groups
surface.
These
influence
optical
electronic
such
photoluminescence,
bandgap,
charge
carrier
mobility,
tunable
specific
Various
characterization
methods
HRTEM,
XPS,
analysis
(PL,
UV)
used
determine
structure
CDs.
cutting-edge
fluorescent
remarkable
qualities
biocompatibility,
low
toxicity,
environmental
friendliness,
high
water
solubility,
photostability.
easily
adjustable
in
terms
highly
various
fields.
find
applications
bio-imaging,
nanomedicine,
drug
delivery,
solar
cells,
photocatalysis,
electrocatalysis,
other
related
areas.
hold
great
promise
field
cell
technology
yield
(CQY),
excellent
separation.
Nanotechnology
sparks
discussions
and
concerns
about
the
impacts
of
new
nanomaterials
on
health
environment.
It
holds
importance
in
various
domains
due
to
its
unique
struc-tures.
Carbon
dots
(C-dots)
are
versatile
with
applications
bioimaging,
sensing,
catalysis,
polymers,
solar
cells,
more.
They
offer
desirable
characteristics
such
as
stability,
cost-effectiveness,
biocompatibility,
high
photoluminescent
quantum
yield.
C-dots
have
potential
replace
expensive
fluorophores
cells.
catego-rized
carbon
dots,
graphene
carbonized
polymer
dots.
outstanding
optical
photoelectric
properties
low
toxicity.
Bottom-up
top-down
approaches
used
for
synthesis
(CDs),
each
method
im-pacting
their
physicochemical
characteristics.
The
choice
depends
de-sired
application
requirements.
Researchers
combine
these
methods
ex-plore
enhance
efficiency
tailor
CD
properties.
CDs
di-verse
chemical
structures
modified
oxygen,
polymer-based,
or
amino
groups
surface.
Various
characterization
HRTEM,
XPS,
analysis
(PL,
UV)
determine
structure.
(CDs)
cutting-edge
fluorescent
nano-materials
remarkable
qualities
toxicity,
environmental
friendliness,
water
solubility,
photo-stability.
easily
adjustable
terms
properties,
making
them
highly
fields.
find
bio-imaging,
nanomedicine,
drug
delivery,
LEDs,
photo-catalysis,
elec-tro-catalysis,
other
related
areas.
Abstract
Colorectal
cancer
is
the
second
most
common
cause
of
cancer‐related
deaths
worldwide
and
third
overall.
In
this
study,
we
investigate
anti‐colon
potential
phytochemically,
thermally
synthesised
novel
green
carbon
dots
based
on
Rhododendron
luteum
(RL‐CDs).
A
new
synthesis
method
was
used
to
produce
obtained
from
(RL)
plant
in
an
environmentally
friendly
manner.
The
RL
were
characterized
using
Fourier‐transform
infrared
spectroscopy
(FTIR),
UV‐Vis
spectroscopy,
transmission
electron
microscopy
(TEM),
artificial
intelligence
(AI)‐based
TEM
analysis.
FTIR
spectrum
showed
peaks
corresponding
hydroxyl
(−OH)
vibration
polyphenols
at
3500
cm
−1
,
C=O
cellulose
derivatives
1728
C−O
stretching
primary
alcohol
1041
.
Two
UV
absorption
roughly
253
nm
(UV−C
range),
320
(UV−B
range)
observed.
size
measured
be
less
than
50
nm,
its
morphology
as
dumbbell‐shaped
through
In‐vitro
studies
performed
with
HCT116
colon
cancer,
MCF‐7
breast
normal
HUVEC
cells.
results
demonstrated
that
RL‐CDs
exhibited
selective
cytotoxic
activity
against
show
extract
stimulates
cell
death
by
decreasing
CD44/24
ratio,
increasing
apoptotic
activity.
These
observations
suggest
could
effective
anticancer
agent
therapy,
investigating
their
direction
a
promising
way
for
future
research.
