Fructose-Derived Carbon Dots as Selective Antitumor Agents in Breast Cancer Therapy: Synthesis, Characterization, and Biological Evaluation DOI Creative Commons
Sofia Magalhães, Carla Luís, Abel J. Duarte

et al.

J — Multidisciplinary Scientific Journal, Journal Year: 2024, Volume and Issue: 7(4), P. 584 - 591

Published: Dec. 22, 2024

This study explored a novel method using fructose-derived carbon dots (FCDs) for antitumor therapy in breast cancer (BC), marking pioneering use of fructose as source nanoparticle synthesis. BC, known its complexity and heterogeneity, was chosen model due to increasing mortality incidence rates. The FCD synthesis involved the decomposition through microwave irradiation, followed by purification characterization techniques such transmission electron microscopy, dynamic light scattering, fluorescence spectrophotometry, Fourier-transform infrared spectroscopy. FCDs, ranging size from 2 6 nm, presented hydrodynamic diameter below spherical morphology, crystalline structure. As expected, FCDs were composed carbon, oxygen, hydrogen, exhibited with absorption emission spectra at 405 nm around 520 respectively. Cell-based assays on epithelial tumor cell lines demonstrated dose-dependent response, decreased viability rate more pronounced cells. In conclusion, showed significant potential selective agents therapy. comprehensive cell-based assay evaluations provided valuable insights into applications these nanoparticles treatment, highlighting their toxicity impact

Language: Английский

Advances in Precision Medicine Approaches for Colorectal Cancer: From Molecular Profiling to Targeted Therapies DOI Creative Commons

Neelakanta Sarvashiva Kiran,

Chandrashekar Yashaswini,

Rahul Maheshwari

et al.

ACS Pharmacology & Translational Science, Journal Year: 2024, Volume and Issue: 7(4), P. 967 - 990

Published: March 19, 2024

Precision medicine is transforming colorectal cancer treatment through the integration of advanced technologies and biomarkers, enhancing personalized effective disease management. Identification key driver mutations molecular profiling have deepened our comprehension genetic alterations in cancer, facilitating targeted therapy immunotherapy selection. Biomarkers such as microsatellite instability (MSI) DNA mismatch repair deficiency (dMMR) guide decisions, opening avenues for immunotherapy. Emerging liquid biopsies, artificial intelligence, machine learning promise to revolutionize early detection, monitoring, selection precision medicine. Despite these advancements, ethical regulatory challenges, including equitable access data privacy, emphasize importance responsible implementation. The dynamic nature with its tumor heterogeneity clonal evolution, underscores necessity adaptive strategies. future lies potential enhance patient care, clinical outcomes, understanding this intricate disease, marked by ongoing evolution field. current reviews focus on providing in-depth knowledge various diverse approaches utilized against at both biochemical levels.

Language: Английский

Citations

18
Anticancer activity of quantum size carbon dots: opportunities and challenges DOI Creative Commons
Tanima Bhattacharya, Subham Preetam, Sohini Mukherjee

et al.

Discover Nano, Journal Year: 2024, Volume and Issue: 19(1)

Published: Aug. 5, 2024

Abstract Research into the anticancer activity of quantum-sized carbon dots (CDs) has emerged as a promising avenue in cancer research. This CDs delves opportunities and challenges associated with harnessing potential these nanostructures for combating cancer. Quantum-sized dots, owing to their unique physicochemical properties, exhibit distinct advantages therapeutic agents. Opportunities lie tunable size, surface functionalization capabilities, biocompatibility, enabling targeted drug delivery imaging cells. However, we include challenges, comprehensive understanding underlying mechanisms, toxicity concerns, optimization synthesis methods enhanced efficacy. A succinct summary state research this area is given review, emphasizing exciting possibilities ongoing utilizing novel strategy treatment.

Language: Английский

Citations

11
Navigating the future of cancer management through carbon nanodots: A review DOI

Arprita Malhan,

Mridul Guleria,

Ushasi Das

et al.

Nano-Structures & Nano-Objects, Journal Year: 2024, Volume and Issue: 39, P. 101217 - 101217

Published: June 17, 2024

Language: Английский

Citations

7
Carbon Dots for Future Prospects: Synthesis, Characterizations and Recent Applications: A Review (2019–2023) DOI Creative Commons

Habtamu Fekadu Etefa,

Aster Aberra Tessema,

F.B. Dejene

et al.

C – Journal of Carbon Research, Journal Year: 2024, Volume and Issue: 10(3), P. 60 - 60

Published: July 5, 2024

Carbon dots (CDs) have emerged as a promising class of carbon-based nanomaterials due to their unique properties and versatile applications. (CDs), also known carbon quantum (CQDs) or graphene (GQDs), are nanoscale materials with dimensions typically less than 10 nanometers. They exhibit intriguing optical, electronic, chemical properties, making them attractive for wide range applications, including sensing, imaging, catalysis, energy conversion, among many others. Both bottom-up top-down synthesis approaches utilized the dots, each method impacting physicochemical characteristics. can diverse structures, amorphous, crystalline, hybrid depending on precursor used. CDs structures modified oxygen, polymer-based, amino groups surface. These influence optical electronic such photoluminescence, bandgap, charge carrier mobility, tunable specific Various characterization methods HRTEM, XPS, analysis (PL, UV) used determine structure CDs. cutting-edge fluorescent remarkable qualities biocompatibility, low toxicity, environmental friendliness, high water solubility, photostability. easily adjustable in terms highly various fields. find applications bio-imaging, nanomedicine, drug delivery, solar cells, photocatalysis, electrocatalysis, other related areas. hold great promise field cell technology yield (CQY), excellent separation.

Language: Английский

Citations

7
One-step hydrothermal synthesis of F,N,S-doped photoluminescent carbon dots with yellowish-orange emission for sensitive Cu2+ ion detection: Environmental and biomedical applications DOI
Sonaimuthu Mohandoss, Kuppu Sakthi Velu, Rizwan Wahab

et al.

Journal of Photochemistry and Photobiology A Chemistry, Journal Year: 2024, Volume and Issue: 459, P. 116037 - 116037

Published: Sept. 16, 2024

Language: Английский

Citations

7
Carbon dots for pathogen detection and imaging: recent breakthroughs and future trends DOI
Sonam Kumari, Monika Nehra, Shikha Jain

et al.

Microchimica Acta, Journal Year: 2024, Volume and Issue: 191(11)

Published: Oct. 21, 2024

Language: Английский

Citations

6
Carbon Dots for Future Prospects: Synthesis, Characterizations and Recent Applications: A Review (2019–2023) DOI Open Access

Habtamu Fekadu Etefa,

Aster Aberra Tessema,

F.B. Dejene

et al.

Published: April 3, 2024

Nanotechnology sparks discussions and concerns about the impacts of new nanomaterials on health environment. It holds importance in various domains due to its unique struc-tures. Carbon dots (C-dots) are versatile with applications bioimaging, sensing, catalysis, polymers, solar cells, more. They offer desirable characteristics such as stability, cost-effectiveness, biocompatibility, high photoluminescent quantum yield. C-dots have potential replace expensive fluorophores cells. catego-rized carbon dots, graphene carbonized polymer dots. outstanding optical photoelectric properties low toxicity. Bottom-up top-down approaches used for synthesis (CDs), each method im-pacting their physicochemical characteristics. The choice depends de-sired application requirements. Researchers combine these methods ex-plore enhance efficiency tailor CD properties. CDs di-verse chemical structures modified oxygen, polymer-based, or amino groups surface. Various characterization HRTEM, XPS, analysis (PL, UV) determine structure. (CDs) cutting-edge fluorescent nano-materials remarkable qualities toxicity, environmental friendliness, water solubility, photo-stability. easily adjustable terms properties, making them highly fields. find bio-imaging, nanomedicine, drug delivery, LEDs, photo-catalysis, elec-tro-catalysis, other related areas.

Language: Английский

Citations

4
Exploring the Multifunctionality of Carbon Dots: Advances in Synthesis, Properties, and Applications DOI

Soumya Pandit,

Nishant Ranjan,

Rajan Verma

et al.

Current Applied Physics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
The legacy of endophytes for the formation of bioactive agents, pigments, biofertilizers, nanoparticles and bioremediation of environment DOI

Anjali Panwar,

Suvendu Manna,

Gayatri Sahini

et al.

World Journal of Microbiology and Biotechnology, Journal Year: 2025, Volume and Issue: 41(2)

Published: Jan. 28, 2025

Language: Английский

Citations

0
In Vitro, Anti‐Colon Cancer Activity of Green Dumbbell‐Shaped Rhododendron luteum‐Based Carbon Dots DOI Creative Commons
Alper Durmaz, İbrahim Mizan Kahyaoğlu, Erdi Can Aytar

et al.

ChemistryOpen, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Abstract Colorectal cancer is the second most common cause of cancer‐related deaths worldwide and third overall. In this study, we investigate anti‐colon potential phytochemically, thermally synthesised novel green carbon dots based on Rhododendron luteum (RL‐CDs). A new synthesis method was used to produce obtained from (RL) plant in an environmentally friendly manner. The RL were characterized using Fourier‐transform infrared spectroscopy (FTIR), UV‐Vis spectroscopy, transmission electron microscopy (TEM), artificial intelligence (AI)‐based TEM analysis. FTIR spectrum showed peaks corresponding hydroxyl (−OH) vibration polyphenols at 3500 cm −1 , C=O cellulose derivatives 1728 C−O stretching primary alcohol 1041 . Two UV absorption roughly 253 nm (UV−C range), 320 (UV−B range) observed. size measured be less than 50 nm, its morphology as dumbbell‐shaped through In‐vitro studies performed with HCT116 colon cancer, MCF‐7 breast normal HUVEC cells. results demonstrated that RL‐CDs exhibited selective cytotoxic activity against show extract stimulates cell death by decreasing CD44/24 ratio, increasing apoptotic activity. These observations suggest could effective anticancer agent therapy, investigating their direction a promising way for future research.

Language: Английский

Citations

0