A Review of Liposomes as a Drug Delivery System: Current Status of Approved Products, Regulatory Environments, and Future Perspectives

Molecules, Год журнала: 2022, Номер 27(4), С. 1372 - 1372

Опубликована: Фев. 17, 2022

Liposomes have been considered promising and versatile drug vesicles. Compared with traditional delivery systems, liposomes exhibit better properties, including site-targeting, sustained or controlled release, protection of drugs from degradation clearance, superior therapeutic effects, lower toxic side effects. Given these merits, several liposomal products successfully approved used in clinics over the last couple decades. In this review, by U.S. Food Drug Administration (FDA) European Medicines Agency (EMA) are discussed. Based on published approval package FDA public assessment report (EPAR) EMA, critical chemistry information mature pharmaceutical technologies applied marketed products, lipid excipient, manufacturing methods, nanosizing technique, loading as well quality attributions (CQAs) introduced. Additionally, current regulatory guidance future perspectives related to summarized. This knowledge can be for research development candidates under various pipelines, laboratory bench, pilot plant, commercial manufacturing.

Язык: Английский

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Immunogenic Cell Death Activates the Tumor Immune Microenvironment to Boost the Immunotherapy Efficiency

Advanced Science, Год журнала: 2022, Номер 9(22)

Опубликована: Июнь 2, 2022

Abstract Tumor immunotherapy is only effective in a fraction of patients due to low response rate and severe side effects, these challenges clinics can be addressed through induction immunogenic cell death (ICD). ICD elicited from many antitumor therapies release danger associated molecular patterns (DAMPs) tumor‐associated antigens facilitate maturation dendritic cells (DCs) infiltration cytotoxic T lymphocytes (CTLs). The process reverse the tumor immunosuppressive microenvironment improve sensitivity immunotherapy. Nanostructure‐based drug delivery systems (NDDSs) are explored induce by incorporating therapeutic molecules for chemotherapy, photosensitizers (PSs) photodynamic therapy (PDT), photothermal conversion agents (PTT), radiosensitizers radiotherapy (RT). These NDDSs loaded at right dose place time, resulting greater effectiveness lower toxicity. Immunotherapeutic also combined with achieve synergic effect multi‐modality approach. In this review, harnessed load multiple PDT, PTT, RT combination promote reduce effects cancer treatment.

Язык: Английский

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Recent Advances in the Development and Antimicrobial Applications of Metal–Phenolic Networks

Advanced Science, Год журнала: 2022, Номер 9(27)

Опубликована: Июль 25, 2022

Due to the abuse of antibiotics and emergence multidrug resistant microorganisms, medical devices, related biomaterials are at high risk microbial infection during use, placing a heavy burden on patients healthcare systems. Metal-phenolic networks (MPNs), an emerging organic-inorganic hybrid network system developed gradually in recent years, have exhibited excellent multifunctional properties such as anti-inflammatory, antioxidant, antibacterial by making use coordination between phenolic ligands metal ions. Further, MPNs received widespread attention antimicrobial infections due their facile synthesis process, biocompatibility, brought about polyphenols In this review, different categories based (nanoparticles, coatings, capsules, hydrogels) fabrication strategies summarized, research advances applications biomedical fields (e.g., skin repair, bone regeneration, etc.) highlighted.

Язык: Английский

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Targeted nanomedicines remodeling immunosuppressive tumor microenvironment for enhanced cancer immunotherapy

Acta Pharmaceutica Sinica B, Год журнала: 2022, Номер 12(12), С. 4327 - 4347

Опубликована: Ноя. 4, 2022

Cancer immunotherapy has significantly flourished and revolutionized the limited conventional tumor therapies, on account of its good safety long-term memory ability. Discouragingly, low patient response rates potential immune-related side effects make it rather challenging to literally bring from bench bedside. However, become evident that, although immunosuppressive microenvironment (TME) plays a pivotal role in facilitating progression metastasis, also provides various targets for remodeling TME, which can consequently bolster effectiveness antitumor suppression. Additionally, particular characteristics turn, be exploited as avenues designing diverse precise targeting nanomedicines. In general, is urgent necessity deliver nanomedicines thus improving therapeutic outcomes clinical translation prospects immunotherapy. Herein, we will illustrate several formation mechanisms TME. More importantly, variety strategies concerning TME strengthening patients' immune systems, reviewed. Ultimately, discuss existing obstacles future perspectives development Hopefully, thriving bloom vibrancy further exploration comprehensive cancer treatment.

Язык: Английский

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Advances in Lung Cancer Treatment Using Nanomedicines

ACS Omega, Год журнала: 2022, Номер 8(1), С. 10 - 41

Опубликована: Дек. 29, 2022

Carcinoma of the lungs is among most menacing forms malignancy and has a poor prognosis, with low overall survival rate due to delayed detection ineffectiveness conventional therapy. Therefore, drug delivery strategies that may overcome undesired damage healthy cells, boost therapeutic efficacy, act as imaging tools are currently gaining much attention. Advances in material science have resulted unique nanoscale-based theranostic agents, which provide renewed hope for patients suffering from lung cancer. Nanotechnology vastly modified upgraded existing techniques, focusing primarily on increasing bioavailability stability anti-cancer drugs. Nanocarrier-based systems treatment carcinoma proven possess considerable benefits, such early targeted effectively treating Several variants nano-drug agents been successfully studied applications, liposomes, dendrimers, polymeric nanoparticles, nanoemulsions, carbon nanotubes, gold magnetic solid lipid hydrogels, micelles. In this Review, we present comprehensive outline various types overexpressed receptors cancer, well targeting approaches nanoparticles.

Язык: Английский

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Impacts of microplastics on immunity

Frontiers in Toxicology, Год журнала: 2022, Номер 4

Опубликована: Сен. 27, 2022

Most disposable plastic products are degraded slowly in the natural environment and continually turned to microplastics (MPs) nanoplastics (NPs), posing additional environmental hazards. The toxicological assessment of MPs for marine organisms mammals has been reported. Thus, there is an urgent need be aware harm human immune system more studies about immunological assessments. This review focuses on how produced they may interact with our body, particularly their responses immunotoxicity. can taken up by cells, thus disrupting intracellular signaling pathways, altering homeostasis finally causing damage tissues organs. generation reactive oxygen species mainly mechanisms after MP exposure, which further induce production danger-associated molecular patterns (DAMPs) associate processes toll-like receptors (TLRs) disruption, cytokine production, inflammatory cells. effectively cell membranes or proteins form a protein-corona, combine external pollutants, chemicals, pathogens greater toxicity strong adverse effects. A comprehensive research immunotoxicity effects MPs, including various chemical compositions, shapes, sizes, combined exposure concentrations, worth studied. Therefore, it urgently needed elucidate hazards risks humans that exposed MPs.

Язык: Английский

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Nucleic acid nanoassembly-enhanced RNA therapeutics and diagnosis

Acta Pharmaceutica Sinica B, Год журнала: 2022, Номер 13(3), С. 916 - 941

Опубликована: Окт. 27, 2022

RNAs are involved in the crucial processes of disease progression and have emerged as powerful therapeutic targets diagnostic biomarkers. However, efficient delivery RNA to targeted location precise detection markers remains challenging. Recently, more attention has been paid applying nucleic acid nanoassemblies diagnosing treating. Due flexibility deformability acids, could be fabricated with different shapes structures. With hybridization, nanoassemblies, including DNA nanostructures, can applied enhance therapeutics diagnosis. This review briefly introduces construction properties their applications for therapy diagnosis makes further prospects development.

Язык: Английский

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Effects of nanoparticle size, shape, and zeta potential on drug delivery

International Journal of Pharmaceutics, Год журнала: 2024, Номер unknown, С. 124799 - 124799

Опубликована: Окт. 1, 2024

Язык: Английский

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The use of photodynamic therapy in medical practice

Frontiers in Oncology, Год журнала: 2024, Номер 14

Опубликована: Май 8, 2024

Cancer therapy, especially for tumors near sensitive areas, demands precise treatment. This review explores photodynamic therapy (PDT), a method leveraging photosensitizers (PS), specific wavelength light, and oxygen to target cancer effectively. Recent advancements affirm PDT’s efficacy, utilizing ROS generation induce cell death. With history spanning over decades, dynamic evolution has expanded its application across dermatology, oncology, dentistry. aims dissect principles, from inception contemporary medical applications, highlighting role in modern treatment strategies.

Язык: Английский

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A large-scale machine learning analysis of inorganic nanoparticles in preclinical cancer research

Nature Nanotechnology, Год журнала: 2024, Номер 19(6), С. 867 - 878

Опубликована: Май 15, 2024

Язык: Английский

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