Biomaterials, Год журнала: 2025, Номер 321, С. 123331 - 123331
Опубликована: Апрель 12, 2025
Язык: Английский
Journal of Biomedical Science, Год журнала: 2023, Номер 30(1)
Опубликована: Окт. 7, 2023
mRNA-based drugs have tremendous potential as clinical treatments, however, a major challenge in realizing this drug class will promise to develop methods for safely delivering the bioactive agents with high efficiency and without activating immune system. With regard mRNA vaccines, researchers modified structure enhance its stability promote systemic tolerance of antigenic presentation non-inflammatory contexts. Still, delivery naked mRNAs is inefficient results low levels antigen protein production. As such, lipid nanoparticles been utilized improve protect cargo from extracellular degradation. This advance was milestone development vaccines dispelled skepticism about technology yield clinically approved medicines. Following resounding success COVID-19, many other proposed treatment variety diseases. review begins discussion modifications vehicles, well factors that influence administration routes. Then, we summarize applications discuss further key points pertaining preclinical targeting wide range Finally, latest market trends future drugs.
Язык: Английский
Процитировано
74
Vaccines, Год журнала: 2024, Номер 12(2), С. 191 - 191
Опубликована: Фев. 13, 2024
Vaccines are essential tools to prevent infection and control transmission of infectious diseases that threaten public health. Most agents enter their hosts across mucosal surfaces, which make up key first lines host defense against pathogens. Mucosal immune responses play critical roles in provide durable better recall responses. Substantial attention has been focused on developing effective vaccines elicit robust localized systemic by administration via routes. yield protection superior parenterally delivered vaccines. Beyond valuable immunogenicity, can be less expensive easier administer without a need for injection materials more highly trained personnel. However, faces many challenges, much effort directed at development. In this article, we review the history vaccine development present an overview compartment biology immunity plays defending infection, knowledge helped inform We explore new progress design optimization novel approaches created improve efficacy safety
Язык: Английский
Процитировано
22
Molecules, Год журнала: 2025, Номер 30(5), С. 1181 - 1181
Опубликована: Март 6, 2025
Nano-drug delivery systems provide targeted solutions for addressing various drug challenges, leveraging nanotechnology to enhance solubility and permeability. Liposomes, explored several decades, face hurdles, especially in oral delivery. Bile-acid stabilized vesicles (bilosomes) are flexible lipid vesicles, composed of phospholipids or other surfactants, along with amphiphilic bile salts, they show superior stability pharmacokinetic behavior comparison conventional vesicular (liposomes niosomes). Bilosomes skin penetration, fluidize the stratum corneum, improve stability. In applications, bilosomes overcome drawbacks, offering improved bioavailability, controlled release, reduced side effects. Vaccines using demonstrate efficacy, intranasal, inhalation, ocular, buccal applications delivery, targeted, efficient, activities. Formulations vary based on active substances optimization techniques, showcasing versatility potential across diverse routes. Therefore, aim this comprehensive review was critically explore state-of-the-art therapeutic applications.
Язык: Английский
Процитировано
2
ACS Nano, Год журнала: 2024, Номер 18(17), С. 11200 - 11216
Опубликована: Апрель 15, 2024
Intranasal vaccines, eliciting mucosal immune responses, can prevent early invasion, replication, and transmission of pathogens in the respiratory tract. However, effective delivery antigens through nasal barrier boosting a robust systematic remain challenges intranasal vaccine development. Here, we describe an intranasally administered self-healing hydrogel with reversible strain-dependent sol-gel transition by precisely modulating self-assembly processes between natural drug rhein aluminum ions. The highly bioadhesive enhances antigen stability prolongs residence time cavity lungs confining to surface mucosa, acting as "mucosal mask". also stimulates superior immunoenhancing properties, including internalization, cross-presentation, dendritic cell maturation. Furthermore, formulation recruits immunocytes mucosa nasal-associated lymphoid tissue (NALT) while enhancing antigen-specific humoral, cellular, responses. Our findings present promising strategy for preparing vaccines infectious diseases or cancer.
Язык: Английский
Процитировано
12
Advanced Materials, Год журнала: 2024, Номер 36(23)
Опубликована: Март 8, 2024
Abstract The sheet‐like lipid bilayer is the fundamental structural component of all cell membranes. Its building blocks are phospholipids and cholesterol. Their amphiphilic structure spontaneously leads to formation a in aqueous environment. Lipids not just elements. Individual species, membrane structure, dynamics influence regulate protein function. An exciting field emerging where membrane‐associated material properties different systems used designing innovative solutions for widespread applications across various fields, such as food industry, cosmetics, nano‐ biomedicine, drug storage delivery, biotechnology, biosensors, computing. Here, authors summarize what known about how lipids determine functions biological membranes this has been or can be translated into applications. Based on recent progress understanding dynamics, physical properties, perspective provided membrane‐controlled regulation extend current even offer new
Язык: Английский
Процитировано
10
Microbiological Research, Год журнала: 2024, Номер 287, С. 127857 - 127857
Опубликована: Июль 26, 2024
The microbiota in the female genital tract is an intricate assembly of diverse aerobic, anaerobic, and microaerophilic microorganisms, which share space within reproductive engage complex interactions. Microbiome dysbiosis may disrupt symbiotic relationship between host microorganisms play a pivotal role pathogenesis various diseases, including its involvement establishment human papillomavirus (HPV)-associated cervical cancer (CC). Interventions to restore homeostasis (e.g., probiotics) bacterial-vector HPV therapeutic vaccines have been reported be potentially effective clearing infection ameliorating cytological abnormalities. In this review, we place emphasis on elucidating alterations cervical-vaginal as well intratumoral context high-risk (HR-HPV) subsequent progression intraepithelial neoplasia/CC. Furthermore, explore mechanisms by these microbial communities exert potential pathogenic or protective effects, modulating inflammation immune responses, affecting HR-HPV oncogene expression oncoprotein production, regulating oxidative stress deoxyribonucleic acid (DNA) damage, inducing metabolic rewiring. Lastly, summarize latest evidence trials regarding efficacy probiotics, prebiotics probiotic-vector vaccines. This review aims foster deeper understanding infection-related cervix development, further provide theoretical basis for development preventive strategies based modulation.
Язык: Английский
Процитировано
10
Biomaterials Science, Год журнала: 2024, Номер 12(8), С. 2057 - 2066
Опубликована: Янв. 1, 2024
A siRNA delivery system was developed using clinically approved mPEG- b -PLGA, cationic lipid and ionizable for cancer immunotherapy.
Язык: Английский
Процитировано
8
RNA Biology, Год журнала: 2024, Номер 21(1), С. 1 - 27
Опубликована: Март 26, 2024
Adjuvanticity and delivery are crucial facets of mRNA vaccine design. In modern vaccines, adjuvant functions integrated into nanoparticles, allowing the co-delivery antigen adjuvants in a unified, all-in-one formulation. this formulation, many vaccines utilize immunostimulating properties carrier components, including lipids polymers, as adjuvants. However, careful design is necessary, excessive adjuvanticity activation improper innate immune signalling can conversely hinder vaccination efficacy trigger adverse effects. also require systems to achieve expression antigen-presenting cells (APCs) within lymphoid organs. Some directly target APCs organs, while others rely on migration draining lymph nodes after taking up vaccines. This review explores current mechanistic understanding these processes ongoing efforts improve safety based understanding.
Язык: Английский
Процитировано
8
Drug delivery, Год журнала: 2025, Номер unknown, С. 223 - 241
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Dentistry Journal, Год журнала: 2025, Номер 13(2), С. 79 - 79
Опубликована: Фев. 13, 2025
Background: Recent advances in mRNA vaccine technology, accelerated by the global COVID-19 pandemic, have generated significant interest their applications beyond infectious diseases. Dentistry has emerged as a promising field for exploring potential of mRNA-based therapies preventing and treating oral Objectives: This narrative review aims to evaluate current status development its preclinical health, focusing on periodontal disease, dental caries, regenerative medicine, implantology, cancer. Methods: The synthesizes findings from studies, including research conducted animal models vitro, assess modulate immune responses promote tissue regeneration cavity. Clinical trials were only mentioned context broader areas implementation such oncology immunotherapy. Results: studies highlight capacity vaccines enhance body's response facilitate repair processes. Despite these results, challenges persist delivering effectively within complex environment. These include stability, delivery mechanisms, modulation responses. Conclusions: While offer promise revolutionizing health care, they face notable limitations concerning safety, efficacy, clinical feasibility. Overcoming obstacles through further is essential unlock full translational ensure safe effective integration into practice.
Язык: Английский
Процитировано
1