Talanta, Год журнала: 2024, Номер 277, С. 126345 - 126345
Опубликована: Июнь 5, 2024
Язык: Английский
International Journal of Pharmaceutics, Год журнала: 2025, Номер 670, С. 125186 - 125186
Опубликована: Янв. 8, 2025
The blood-brain barrier (BBB) plays a vital role in protecting the central nervous system (CNS) by preventing entry of harmful pathogens from bloodstream. However, this also presents significant obstacle when it comes to delivering drugs for treatment neurodegenerative diseases and brain cancer. Recent breakthroughs nanotechnology have paved way creation wide range nanoparticles (NPs) that can serve as carriers diagnosis therapy. Regarding their promising properties, organic NPs potential be used effective drug delivery across BBB based on recent advancements. These remarkable ability penetrate using various mechanisms. This review offers comprehensive examination intricate structure distinct properties BBB, emphasizing its crucial function preserving balance regulating transport ions molecules. disruption conditions such stroke, Alzheimer's disease, Parkinson's disease highlights importance developing creative approaches drugs. Through encapsulation therapeutic molecules precise targeting processes vasculature, NP formulations present hopeful strategy improve BBB. We explore changes pathological investigate factors affect successful into brain. In addition, we most systems associated with shown positive results treating ischemic disorders. opens up new possibilities nanotechnology-based therapies cerebral diseases.
Язык: Английский
Процитировано
12
Journal of Clinical Medicine, Год журнала: 2025, Номер 14(2), С. 386 - 386
Опубликована: Янв. 9, 2025
The blood-brain barrier (BBB) is a crucial structure that maintains brain homeostasis by regulating the entry of molecules and cells from bloodstream into central nervous system (CNS). Neurodegenerative diseases such as Alzheimer's Parkinson's disease, well ischemic stroke, compromise integrity BBB. This leads to increased permeability infiltration harmful substances, thereby accelerating neurodegeneration. In this review, we explore mechanisms underlying BBB disruption, including oxidative stress, neuroinflammation, vascular dysfunction, loss tight junction integrity, in patients with neurodegenerative diseases. We discuss how breakdown contributes neurotoxicity, abnormal accumulation pathological proteins, all which exacerbate neuronal damage facilitate disease progression. Furthermore, potential therapeutic strategies aimed at preserving or restoring function, anti-inflammatory treatments, antioxidant therapies, approaches enhance integrity. Given role neurodegeneration, maintaining its represents promising approach slow prevent progression
Язык: Английский
Процитировано
5
Antioxidants, Год журнала: 2025, Номер 14(2), С. 155 - 155
Опубликована: Янв. 28, 2025
The aim of this study was to investigate the antioxidant capacity fruit wines and their protective effects against hydrogen peroxide-induced oxidative stress in rat synaptosomes vitro. were produced from strawberries drupe fruits (i.e., plum, sweet cherry, peach, apricot) through microvinification with a pure S. cerevisiae yeast culture. Fruit without added sugar before start fermentation, whereas subvariants pits only applied wines. First, treated wines, while induced H2O2. Subsequently, activities enzymes (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx)) content malondialdehyde (MDA), an indicator membrane injury, determined. In addition, Briggs–Rauscher reaction (BR) used evaluate inhibition free radicals. All investigated increased activity studied decreased MDA compared corresponding controls (synaptosomes H2O2). After synaptosomal treatment plum wine, highest observed for SOD (5.57 U/mg protein) GPx (0.015 protein). Strawberry wine CAT (0.047 showed best ability reduce lipid peroxidation, yielding lowest level (2.68 nmol/mg). Strawberry, cherry identified as samples higher both principal component analysis (PCA) hierarchical cluster (HCA). Finally, exhibited inhibitory BR (397 s). results suggest that could be considered potential functional food due stress.
Язык: Английский
Процитировано
5
Cells, Год журнала: 2025, Номер 14(7), С. 511 - 511
Опубликована: Март 29, 2025
Oxidative stress (OS) is an established hallmark of cancer and neurodegenerative disorders (NDDs), which contributes to genomic instability neuronal loss. This review explores the contrasting role OS in stem cells (CSCs) NDDs. Elevated levels reactive oxygen species (ROS) contribute promote tumor initiation progression CSCs, while NDDs such as Alzheimer’s Parkinson’s disease, accelerates death impairs cellular repair mechanisms. Both scenarios involve disruption delicate balance between pro-oxidant antioxidant systems, leads chronic oxidative stress. Notably, CSCs neurons display alterations redox-sensitive signaling pathways, including Nrf2 NF-κB, influence cell survival, proliferation, differentiation. Mitochondrial dynamics further illustrate these differences: enhanced function supports adaptability whereas impairments heighten vulnerability. Understanding common mechanisms OS-induced redox imbalance may provide insights for developing interventions, addressing aging hallmarks, potentially mitigating or preventing both
Язык: Английский
Процитировано
5
Nutrients, Год журнала: 2023, Номер 15(24), С. 5116 - 5116
Опубликована: Дек. 15, 2023
Cognitive impairment and dementia are burgeoning public health concerns, especially given the increasing longevity of global population. These conditions not only affect quality life individuals their families, but also pose significant economic burdens on healthcare systems. In this context, our comprehensive narrative review critically examines role nutritional supplements in mitigating cognitive decline. Amidst growing interest non-pharmacological interventions for enhancement, delves into efficacy vitamins, minerals, antioxidants, other dietary supplements. Through a systematic evaluation randomized controlled trials, observational studies, meta-analysis, focuses outcomes such as memory attention improvement, executive function support, neuroprotection. The findings suggest complex interplay between supplementation health, with some showing promising results others displaying limited or context-dependent effectiveness. highlights importance dosage, bioavailability, individual differences response to supplementation. Additionally, it addresses safety concerns potential interactions conventional treatments. By providing clear overview current scientific knowledge, aims guide professionals researchers making informed decisions about use health.
Язык: Английский
Процитировано
34
Journal of Alzheimer s Disease, Год журнала: 2023, Номер 96(4), С. 1353 - 1382
Опубликована: Ноя. 7, 2023
Diet is an important nonpharmacological risk-modifying factor for Alzheimer's disease (AD). The approaches used here to assess diet's role in the risk of AD include multi-country ecological studies, prospective and cross-sectional observational laboratory studies. Ecological studies have identified fat, meat, obesity from high-energy diets as factors reported that rates peak about 15-20 years after national dietary changes. Observational compared Western pattern with those Dietary Approaches Stop Hypertension (DASH), Mediterranean (MedDi), Mediterranean-DASH Intervention Neurodegenerative Delay (MIND) diets. Those including higher consumption saturated total fats, ultraprocessed foods a lower fruits, legumes, nuts, omega-3 fatty acids, vegetables, whole grains. Diet-induced associated significant inflammation, insulin resistance, oxidative stress, elevated homocysteine, advanced glycation end products, trimethylamine N-oxide. molecular mechanisms by which bioactive components specific affect are discussed. Given most countries' entrenched food supply systems, upward trends would be hard reverse. However, people willing able, low-animal product diet plenty anti-inflammatory, low-glycemic load may helpful.
Язык: Английский
Процитировано
33
Ageing Research Reviews, Год журнала: 2024, Номер 98, С. 102224 - 102224
Опубликована: Фев. 10, 2024
Язык: Английский
Процитировано
16
Food Science & Nutrition, Год журнала: 2024, Номер 12(11), С. 8715 - 8741
Опубликована: Окт. 16, 2024
Certain carotene components, such as lycopene and beta-carotene, are found in tomatoes, carrots, sweet potatoes, etc. good for human health. It gives plants their distinctive red color. A class of lipid-soluble natural pigments known carotenoids is the precursor vitamin vital antioxidant defense against peroxides cells tissues. This review provides an overview current state knowledge research on sources, structures, physiochemical properties, absorption metabolism, functional advantages, prevention many diseases associated with beta-carotene. These antioxidants have been linked to a lower risk cardiovascular disease cancer, they also help draw pollinators flowers. Carrots potatoes rich sources which strengthens immune system improves eye The vivid color reproductive organs, including flowers fruits, caused by carotenoid, secondary metabolite that produced plastids. other health advantages attributed lycopene. When ingested through food or supplements, beta-carotene manage prevent number diseases, metabolic, inflammatory, cardiovascular, hepatic, ophthalmic, skeletal, infertility disorders. main point toxicity uncommon, these generally accepted be safe at different doses. Including nutrients your diet can improve general provide illness prevention.
Язык: Английский
Процитировано
16
Molecules, Год журнала: 2024, Номер 29(5), С. 967 - 967
Опубликована: Фев. 22, 2024
Carotenoids, which are inherent pigments occurring in plants and microorganisms, manifest a diverse array of vivid hues. Owing to their multifarious health advantages, carotenoids have engendered substantial interest among scholars consumers alike. Presently, extensively employed the realms food, nutrition commodities, pharmaceuticals, cosmetics, rendering them an indispensable constituent our quotidian existence. Therefore, objective this review is present succinct methodical examination sources, constituents, factors influencing formation carotenoids. Particular attention will be given encapsulation strategies that maintain intrinsic characteristics, as growing desire for propelled by individuals’ escalating standards living. Moreover, applications natural multiple fields, including pharmaceutical, food feed, well discussed detail. Finally, article explores main challenges hindering future advancement carotenoids, aiming at facilitating effective integration into circular economy.
Язык: Английский
Процитировано
14
Current Research in Food Science, Год журнала: 2024, Номер 8, С. 100753 - 100753
Опубликована: Янв. 1, 2024
Camellia oleifera oil is a pure and natural high-grade prevalent in South China. known for its richness unsaturated fatty acids high nutritional value. There increasing evidence indicating that diet rich beneficial to health. Despite the widespread production of bioactive components, reports on components are scarce, especially regarding systematic reviews extraction methods biological functions. This review systematically summarized latest research functions reported over past decade. In addition acids, contains six main functional contributing antioxidant, antibacterial, anti-inflammatory, antidiabetic, anticancer, neuroprotective, cardiovascular protective properties. These vitamin E, saponins, polyphenols, sterols, squalene, flavonoids. paper reviewed activity methods, laying foundation further development components.
Язык: Английский
Процитировано
11