Advanced Healthcare Materials,
Год журнала:
2024,
Номер
14(2)
Опубликована: Дек. 4, 2024
Abstract
Cancer
treatment
has
witnessed
revolutionary
advancements
marked
by
the
emergence
of
immunotherapy,
specifically
immune
checkpoint
blockade
(ICB).
However,
inherent
low
immunogenicity
tumor
cells
and
intricate
immunosuppressive
network
within
microenvironment
(TME)
pose
significant
challenges
to
further
development
immunotherapy.
Nanotechnology
ushered
in
unprecedented
opportunities
vast
prospects
for
Nevertheless,
traditional
nano‐formulations
often
rely
on
inducing
apoptosis
kill
cancer
cells,
which
encounters
issue
silencing,
hindering
effective
activation.
The
non‐apoptotic
modes
regulated
cell
death
(RCD),
including
pyroptosis,
ferroptosis,
autophagy,
necroptosis,
cuproptosis,
have
gradually
garnered
attention.
These
pathways
can
induce
immunogenic
(ICD),
enhancing
This
review
comprehensively
explores
advanced
nano‐formulation
design
strategies
their
applications
immunotherapy
promoting
RCD
recent
years.
It
also
discusses
potential
advantages
these
tumor‐specific
RCD.
By
deeply
understanding
significance
synergistic
this
article
provides
valuable
insights
developing
more
nano‐delivery
systems
that
robustly
highly
modes,
offering
novel
research
avenues
address
clinical
encountered
represented
ICB.
Journal of Hematology & Oncology,
Год журнала:
2024,
Номер
17(1)
Опубликована: Авг. 16, 2024
Cuproptosis
is
a
newly
identified
form
of
cell
death
induced
by
excessive
copper
(Cu)
accumulation
within
cells.
Mechanistically,
cuproptosis
results
from
Cu-induced
aggregation
dihydrolipoamide
S-acetyltransferase,
correlated
with
the
mitochondrial
tricarboxylic
acid
cycle
and
loss
iron–sulfur
cluster
proteins,
ultimately
resulting
in
proteotoxic
stress
triggering
death.
Recently,
has
garnered
significant
interest
tumor
research
due
to
its
potential
as
crucial
therapeutic
strategy
against
cancer.
In
this
review,
we
summarized
cellular
molecular
mechanisms
relationship
other
types
Additionally,
reviewed
current
drugs
or
strategies
available
induce
cells,
including
Cu
ionophores,
small
compounds,
nanomedicine.
Furthermore,
targeted
metabolism
specific
regulatory
genes
cancer
therapy
enhance
sensitivity
cuproptosis.
Finally,
discussed
feasibility
targeting
overcome
chemotherapy
immunotherapy
resistance
suggested
future
directions.
This
study
that
could
open
new
avenues
for
developing
therapy.
Nano Letters,
Год журнала:
2024,
Номер
24(22), С. 6767 - 6777
Опубликована: Май 21, 2024
Efforts
to
prolong
the
blood
circulation
time
and
bypass
immune
clearance
play
vital
roles
in
improving
therapeutic
efficacy
of
nanoparticles
(NPs).
Herein,
a
multifunctional
nanoplatform
(BPP@RTL)
that
precisely
targets
tumor
cells
is
fabricated
by
encapsulating
ultrasmall
phototherapeutic
agent
black
phosphorus
quantum
dot
(BPQD),
chemotherapeutic
drug
paclitaxel
(PTX),
immunomodulator
PolyMetformin
(PM)
hybrid
membrane-camouflaged
liposomes.
Specifically,
cell
membrane
coating
derived
from
fusion
cancer
red
displays
excellent
targeting
efficiency
long
property
due
innate
features
both
membranes.
After
collaboration
with
aPD-L1-based
checkpoint
blockade
therapy,
boosted
immunotherapeutic
effect
obtained
elevated
dendritic
maturation
T
activation.
Significantly,
laser-irradiated
BPP@RTL
combined
aPD-L1
effectively
eliminates
primary
tumors
inhibits
lung
metastasis
4T1
breast
model,
offering
promising
treatment
plan
develop
personalized
antitumor
strategy.
Copper-based
nanoparticles
have
garnered
significant
interest
in
cancer
therapy
due
to
their
ability
induce
oxidative
stress
and
cuproptosis
cells.
However,
antitumor
effectiveness
is
constrained
by
the
dynamic
redox
balance
metabolic
shift
between
phosphorylation
glycolysis.
Here,
a
polydopamine-coated
copper-α-ketoglutaric
acid
(α-KG)
coordination
polymer
nanoparticle
(CKPP)
designed
for
combined
pyroptosis-cuproptosis
immunotherapy
amplifying
reactive
oxygen
species
(ROS)
production
regulating
cellular
metabolism.
The
intracellular
imbalance
achieved
through
synergistic
effects
of
α-KG-induced
mitochondrial
reprogramming,
photothermally
enhanced
superoxide
dismutase-like
activity
polydopamine,
glutathione
depletion
copper
ions.
multifaceted
modulation
results
substantial
increase
ROS
levels,
triggering
subsequent
pyroptosis
Furthermore,
α-KG
shifts
metabolism
from
glycolysis
phosphorylation,
thereby
enhancing
induced
combination
dyshomeostasis
inhibition
potent
enhancement
pyroptosis-cuproptosis-mediated
therapy.
In
murine
model
colorectal
cancer,
CKPP
exhibited
remarkable
anticancer
effect,
achieving
tumor
rate
96.3%
complete
eradication
two
out
five
cases.
Overall,
this
bio-engineered
metal-organic
nanocomposite
demonstrates
potential
treating
immunotherapy.
Cellular & Molecular Biology Letters,
Год журнала:
2024,
Номер
29(1)
Опубликована: Июнь 25, 2024
Abstract
Cuproptosis,
a
newly
identified
copper
(Cu)-dependent
form
of
cell
death,
stands
out
due
to
its
distinct
mechanism
that
sets
it
apart
from
other
known
death
pathways.
The
molecular
underpinnings
cuproptosis
involve
the
binding
Cu
lipoylated
enzymes
in
tricarboxylic
acid
cycle.
This
interaction
triggers
enzyme
aggregation
and
proteotoxic
stress,
culminating
death.
specific
has
yet
be
fully
elucidated.
recognized
sparked
numerous
investigations
into
role
tumorigenesis
cancer
therapy.
In
this
review,
we
summarized
current
knowledge
on
metabolism
link
cancer.
Furthermore,
delineated
mechanisms
roles
cuproptosis-related
genes
Finally,
offered
comprehensive
discussion
most
recent
advancements
ionophores
nanoparticle
delivery
systems
utilize
as
cutting-edge
strategy
for
treatment.
Journal of Materials Chemistry B,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
This
review
discusses
the
recent
developments
in
copper-based
nanomaterials
that
utilize
copper-induced
cell
death,
categorized
by
materials
systems,
while
highlighting
limitations
of
current
cuproptosis
related
nanomaterials.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 24, 2024
The
dysfunction
of
gut
microbiome
and
bile
acid
metabolism
might
cause
the
incidence
relapse
ulcerative
colitis
(UC).
Thus,
natural
products
have
been
considered
effective
for
UC
through
regulation
acid.
In
this
study,
we
evaluated
regulatory
effect
berberine
on
in
UC.
Results
showed
that
relative
abundances
beneficial
bacteria
a
decreasing
trend
model,
taurine
conjugated
acids
increased
from
liver
tissue
to
colon
tissue.
Berberine
inhibited
colonization
harmful
promoted
primary
metabolism.
Moreover,
used
multi-omics
technology
(metagenomics,
metabolomics,
transcriptomics
technology)
reveal
restored
intestinal
barrier
function
acid/S1PR2/RhoA/ROCK
pathway.
result
transmission
electron
microscopy
directly
damaged
mucosal
was
repaired
treatment.
This
study
revealed
treatment
influence
