ACS Nano,
Год журнала:
2024,
Номер
18(46), С. 32103 - 32117
Опубликована: Ноя. 9, 2024
Pulmonary
delivery
of
anticancer
therapeutics
has
shown
encouraging
performance
in
treating
nonsmall
cell
lung
cancer
(NSCLC),
which
is
characterized
by
high
aggressiveness
and
poor
prognosis.
Cisplatin,
a
key
member
the
family
DNA
alkylating
agents,
extensively
employed
during
NSCLC
therapy.
However,
development
chemoresistance
occurrence
side
effects
severely
impede
long-term
application
cisplatin-based
chemotherapies.
Herein,
we
propose
meaningful
strategy
to
precisely
treat
cisplatin-resistant
based
on
combination
bioorthogonal
chemistry
with
an
inhalation
approach.
Ethacraplatin
(EA-Pt),
platinum
prodrug
(IV),
was
synthesized
encapsulated
nitric
oxide
(NO)-containing
micelles
overcome
cisplatin
chemoresistance.
By
further
modifying
molecules
this
nanoplatform
(EA-Pt@M
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 15, 2024
Exploring
effective
antibacterial
approaches
for
targeted
treatment
of
pathogenic
bacterial
infections
with
reduced
drug
resistance
is
great
significance.
Combinational
modality
that
leverages
different
therapeutic
components
can
improve
the
overall
effectiveness
and
minimize
adverse
effects,
thus
displaying
considerable
potential
against
infections.
Herein,
red
blood
cell
membrane
fuses
macrophage
to
develop
hybrid
shell,
which
further
camouflages
around
drug-loaded
liposome
fabricate
biomimetic
(AB@LRM)
precise
therapy.
Specifically,
photoactive
agent
black
phosphorus
quantum
dots
(BPQDs)
classical
antibiotics
amikacin
(AM)
are
loaded
in
AB@LRM
accurately
target
inflammatory
sites
through
guidance
long
residence
capability
membrane,
eventually
exerting
efficacious
activities.
Besides,
due
excellent
photothermal
photodynamic
properties,
BPQDs
act
as
an
efficient
when
exposed
near-infrared
laser
irradiation,
dramatically
increasing
sensitivity
bacteria
antibiotics.
Consequently,
synergistic
sterilizing
effect
produced
by
restricts
resistance.
Upon
shows
superior
anti-inflammatory
properties
models
P.
aeruginosa-infected
pneumonia
wounds.
Hence,
this
light-activatable
nanoplatform
good
biocompatibility
presents
advance
clinical
development
Chemical Society Reviews,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 2, 2024
Black
phosphorus
nanomaterials
have
opened
new
doors
to
cancer
therapy.
They
can
induce
anticancer
activities
intrinsically
(selectively)
and/or
with
external
stimuli
(PTT,
PDT,
SDT,
etc.
)
and
are
highly
suitable
for
drug/gene
delivery.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Abstract
Violet
phosphorus
(VP)
is
a
allotrope
first
discovered
by
Hittorf
in
1865,
which
has
aroused
more
attention
the
biomedical
field
recent
years
attributed
to
its
gradually
unique
properties.
VP
can
be
further
categorized
into
bulk
VP,
nanosheets
(VPNs),
and
quantum
dots
(VPQDs),
chemical
vapor
transport
(CVT),
liquid‐phase/mechanical/laser
exfoliation,
solvothermal
synthesis
are
common
preparation
approaches
of
VPNs,
VPQDs,
respectively.
Compared
with
another
(black
phosphorus,
BP)
that
once
highly
regarded
applications,
nanomaterial
(namely
VPNs
VPQDs)
not
only
exhibits
tunable
bandgap,
moderate
on/off
current
ratio,
good
biodegradability,
but
shows
enhanced
stability
biosafety
as
well,
allowing
it
promising
candidate
for
variety
applications
like
antibacterial
therapy,
anticancer
biosensing
disease
diagnosis.
In
this
review,
classification
relevant
routes
initially
summarized,
properties
momentous
subsequently
expounded.
The
latest
research
advances
emerging
then
introduced
detail,
both
existing
challenges
future
prospects
also
discussed.
ACS Applied Bio Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 11, 2024
Cancer
is
becoming
a
global
threat,
as
the
cancerous
cells
manipulate
themselves
frequently,
resulting
in
mutants
and
more
abnormalities.
Early-stage
real-time
detection
of
cancer
biomarkers
can
provide
insight
into
designing
cost-effective
diagnostic
therapeutic
modalities.
Nanoparticle
quantum
dot
(QD)-based
approaches
have
been
recognized
clinically
relevant
methods
to
detect
disease
at
molecular
level.
Over
decades,
an
emergent
noninvasive
approach,
photothermal
therapy
has
evolved
eradicate
cancer.
Moreover,
various
structures,
viz.,
nanoparticles,
clusters,
dots,
etc.,
tested
bioimaging
agents
identify
tumor
selectively.
Among
them,
QDs
versatile
probes.
They
attracted
enormous
attention
for
imaging
applications
due
their
unique
colloidal
stability,
optical
physicochemical
properties,
biocompatibility,
easy
surface
conjugation,
scalable
production,
etc.
However,
few
critical
concerns
QDs,
precise
engineering
sensing,
selective
interaction
with
biological
system,
associated
toxicity,
restrict
potential
intervention
curing
are
yet
be
explored.
According
U.S.
Food
Drug
Administration
(FDA),
there
no
specific
regulation
approval
nanomedicines.
Therefore,
these
nanomedicines
undergo
traditional
drug,
biological,
device
process.
market
survey
increasing,
prospects
translational
nanomedicine
very
promising.
From
this
perspective,
we
discuss
importance
imaging,
usage
pertinent
cancer,
especially
its
early
stages.
also
rapidly
growing
view
QDs.
The
long-term
safety
studies
cellular
could
enhance
visibility
bring
photothermally
active
clinical
stage
concurrently
FDA
approval.
Cancer
remains
a
global
health
challenge,
driving
the
need
for
advanced
treatments.
While
transition
metal
dichalcogenides
(TMDs)
show
promise
in
cancer
therapy,
their
stability
and
efficacy
require
improvement.
This
study
explores
TMD-based
composites
as
solution
to
enhance
therapeutic
potential.
review
begins
by
providing
an
overview
of
TMDs
emphasizing
preparation
techniques
fundamental
properties.
The
focus
is
then
shifted
categorizing
based
on
constituent
materials,
delving
into
various
types,
such
TMD-organic,
TMD-carbon,
TMD-metal
chalcogenide,
TMD-metal,
TMD-oxide
composites,
well
more
complex
ternary
multinary
systems.
We
further
explore
key
fabrication
strategies,
including
hydrothermal/solvothermal
methods
surface
deposition/coating
techniques.
Subsequently,
applications
treatment,
chemotherapy,
photothermal
phototherapy,
integrated
combination
therapies.
Finally,
critical
challenges
field
perspectives
potential
directions
future
research
are
presented.
