Food Science & Nutrition,
Год журнала:
2024,
Номер
13(1)
Опубликована: Дек. 31, 2024
ABSTRACT
Coumarins,
a
group
of
naturally
occurring
compounds,
have
been
reported
to
demonstrate
anticancer
potential.
These
substances,
distinguished
by
their
combined
benzene
and
α‐pyrone
rings,
demonstrated
impact
multiple
cellular
mechanisms
essential
for
the
initiation
advancement
cancer.
agents
work
in
different
ways
that
prevent
tumor
cells
from
growing,
spreading,
increasing.
One
main
coumarin
act
is
killing
cancer
through
apoptosis.
This
includes
changes
pro‐
anti‐apoptotic
proteins
like
Bcl‐2
Bax,
release
cytochrome
c
mitochondria,
activation
caspases.
The
suppressor
protein
p53's
expression
has
discovered
be
upregulated
coumarins
such
as
esculetin
imperatorin,
which
encourage
interrupted
cell
cycle
death.
Additionally,
anti‐angiogenic
qualities,
are
critical
development
spread
tumors.
It
can
slow
new
blood
vessels
feed
tumors
inhibiting
“vascular
endothelial
growth
factor
(VEGF)”
route
signaling.
Coumarins
inhibit
number
signaling
pathways
vital
division.
For
example,
they
suppress
“PI3K/mTOR”
pathway,
usually
impairs
results
decreased
viability
growth.
Finally,
could
modulate
response
immune
system
cancerous
cells.
They
ability
boost
activity
natural
killer
cytotoxic
T
lymphocytes,
aid
identifying
eliminating
Through
variety
mechanisms,
regulation,
angiogenesis
reduction,
inhibition,
apoptosis
activation,
exhibit
effects.
molecular
coumarins'
potential
an
interesting
option
novel
treatments.
More
studies
needed
completely
understand
modes
action
maximize
therapeutic
efficacy.
Pharmaceuticals,
Год журнала:
2023,
Номер
16(5), С. 651 - 651
Опубликована: Апрель 26, 2023
Ubiquitously
present
in
plant
life,
coumarins,
as
a
class
of
phenolic
compounds,
have
multiple
applications-in
everyday
organic
synthesis,
medicine
and
many
others.
Coumarins
are
well
known
for
their
broad
spectrum
physiological
effects.
The
specific
structure
the
coumarin
scaffold
involves
conjugated
system
with
excellent
charge
electron
transport
properties.
antioxidant
activity
natural
coumarins
has
been
subject
intense
study
at
least
two
decades.
Significant
research
into
behavior
natural/semi-synthetic
complexes
carried
out
published
scientific
literature.
authors
this
review
noted
that,
during
past
five
years,
efforts
seem
to
focused
on
synthesis
examination
synthetic
derivatives
aim
produce
potential
drugs
enhanced,
modified
or
entirely
novel
As
pathologies
associated
oxidative
stress,
coumarin-based
compounds
could
be
candidates
medicinal
molecules.
aims
inform
reader
some
prominent
results
from
investigations
properties
over
years.
Pharmaceuticals,
Год журнала:
2023,
Номер
16(12), С. 1732 - 1732
Опубликована: Дек. 15, 2023
Umbelliferone
(UMB),
known
as
7-hydroxycoumarin,
hydrangine,
or
skimmetine,
is
a
naturally
occurring
coumarin
in
the
plant
kingdom,
mainly
from
Umbelliferae
family
that
possesses
wide
variety
of
pharmacological
properties.
In
addition,
use
nanoparticles
containing
umbelliferone
may
improve
anti-inflammatory
anticancer
therapy.
Also,
its
derivatives
are
endowed
with
great
potential
for
therapeutic
applications
due
to
their
broad
spectrum
biological
activities
such
anti-inflammatory,
antioxidant,
neuroprotective,
antipsychotic,
antiepileptic,
antidiabetic,
antimicrobial,
antiviral,
and
antiproliferative
effects.
Moreover,
7-hydroxycoumarin
ligands
have
been
implemented
develop
7-hydroxycoumarin-based
metal
complexes
improved
activity.
Besides
applications,
analogues
designed
fluorescent
probes
detection
biologically
important
species,
enzymes,
lysosomes,
endosomes,
monitoring
cell
processes
protein
functions
well
various
diseases
caused
by
an
excess
hydrogen
peroxide.
Furthermore,
7-hydroxy-based
chemosensors
serve
highly
selective
tool
Al3+
Hg2+
systems.
This
review
devoted
summary
research
on
synthetic
terms
pharmaceutical
properties,
especially
those
reported
literature
during
period
2017-2023.
Future
presented.
