Synergistic Interactions Between Probiotics and Anticancer Drugs: Mechanisms, Benefits, and Challenges
Probiotics and Antimicrobial Proteins,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 28, 2025
Язык: Английский
Probiotics: health benefits, microencapsulation, and viability, combination with natural compounds, and applications in foods
Food Bioscience,
Год журнала:
2025,
Номер
unknown, С. 106253 - 106253
Опубликована: Фев. 1, 2025
Язык: Английский
Crosstalk between ROS-inflammatory gene expression axis in the progression of lung disorders
Naunyn-Schmiedeberg s Archives of Pharmacology,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 28, 2024
Язык: Английский
Immunomodulatory effects of Lactiplantibacillus plantarum CCFM8661 + stachyose on cyclophosphamide-induced immunosuppression mice
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 27, 2025
Introduction
The
increasing
stress
of
modern
life
has
led
to
a
decline
in
immunity,
sparking
widespread
interest
new
strategies
boost
immune
function.
Lactiplantibacillus
plantarum
and
stachyose
have
gained
attention
for
their
immune-regulating
effects,
but
the
mechanisms
combined
application
remain
unclear.
This
study
aims
investigate
immunoregulatory
effects
CCFM8661
with
cyclophosphamide-induced
immunocompromised
mice.
Methods
Mice
were
divided
into
normal
control
group,
model
group
(normal
saline),
positive
drug
(levamisole
hydrochloride,
10
mg/kg),
low,
medium,
high-dose
groups
(1.5×10
5
,
1.5×10
6
7
CFU
+
1.5
mg
stachyose).
Each
treatment
received
continuous
oral
gavage
administration
28
days.
On
days
23
24,
except
all
other
intraperitoneally
injected
cyclophosphamide
(40
mg/kg)
establish
an
immunosuppressed
model.
day
28,
30
minutes
after
final
administration,
mice
euthanized
collect
thymus,
spleen,
serum,
ileum,
feces
subsequent
analysis
indicators,
intestinal
barrier
function,
serum
cytokines,
microbiota.
Results
combination
significantly
improved
organ
atrophy,
restored
morphology,
normalized
cytokine
levels
mice,
indicating
enhanced
Additionally,
it
microbiota
diversity
by
abundance
Muribaculaceae
while
reducing
Lachnospiraceae
potentially
promoting
homeostasis.
Discussion
immune-enhancing
achieved
regulating
inflammation
maintaining
Язык: Английский
Genetic and Molecular Profiling in Merkel Cell Carcinoma: Focus on MCPyV Oncoproteins and Emerging Diagnostic Techniques
Pathology - Research and Practice,
Год журнала:
2025,
Номер
unknown, С. 155869 - 155869
Опубликована: Фев. 1, 2025
Язык: Английский
Silk fibroin: An innovative protein macromolecule-based hydrogel/scaffold revolutionizing breast cancer treatment and diagnosis – Mechanisms, advancements, and targeting capabilities
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 142870 - 142870
Опубликована: Апрель 1, 2025
Язык: Английский
Development of optimized resveratrol/piperine-loaded phytosomal nanocomplex for isoproterenol-induced myocardial infarction treatment
Journal of Liposome Research,
Год журнала:
2024,
Номер
34(4), С. 640 - 657
Опубликована: Июль 12, 2024
Cardiovascular
disease
is
a
significant
and
ever-growing
concern,
causing
high
morbidity
mortality
worldwide.
Conventional
therapy
often
very
precarious
requires
long-term
usage.
Several
phytochemicals,
including
Resveratrol
(RSV)
Piperine
(PIP),
possess
cardioprotection
may
be
restrained
in
clinical
settings
due
to
inadequate
pharmacokinetic
properties.
Therefore,
this
study
strives
develop
an
optimized
RSV
phytosomes
(RSVP)
co-loaded
with
PIP
(RPP)
via
solvent
evaporation
method
using
Box-Behnken
design
enhance
the
properties
isoproterenol-induced
myocardial
infarction
(MI).
The
particle
size
(20.976
±
0.39
176.53
0.88
nm),
zeta
potential
(−33.33
1.5
−48.7
1.6
mV),
drug
content
(84.57
0.9
87.16
0.6%),
%EE
(70.56
0.7
67.60
0.57%)
of
prepared
RSVP
RPP,
respectively
demonstrated
enhanced
solubility
control
release
diffusion
media.
oral
administration
RPP
infarction-induced
rats
exhibited
(p
<
0.001)
improvement
heart
rate,
ECG,
biomarker,
anti-oxidant
levels,
no
inflammation
than
pure
RSV.
assessment
on
healthy
Wistar
prolonged
circulation
(>24
h)
compared
free
drug/s.
ability
penetrate
bio-membranes
enter
systemic
renders
them
more
promising
strategy
for
mitigating
MI.
Язык: Английский