Development of optimized resveratrol/piperine-loaded phytosomal nanocomplex for isoproterenol-induced myocardial infarction treatment DOI

Thriveni Raunak Salian,

Nadira Noushida, Sourav Mohanto

et al.

Journal of Liposome Research, Journal Year: 2024, Volume and Issue: 34(4), P. 640 - 657

Published: July 12, 2024

Cardiovascular disease is a significant and ever-growing concern, causing high morbidity mortality worldwide. Conventional therapy often very precarious requires long-term usage. Several phytochemicals, including Resveratrol (RSV) Piperine (PIP), possess cardioprotection may be restrained in clinical settings due to inadequate pharmacokinetic properties. Therefore, this study strives develop an optimized RSV phytosomes (RSVP) co-loaded with PIP (RPP) via solvent evaporation method using Box-Behnken design enhance the properties isoproterenol-induced myocardial infarction (MI). The particle size (20.976 ± 0.39 176.53 0.88 nm), zeta potential (−33.33 1.5 −48.7 1.6 mV), drug content (84.57 0.9 87.16 0.6%), %EE (70.56 0.7 67.60 0.57%) of prepared RSVP RPP, respectively demonstrated enhanced solubility control release diffusion media. oral administration RPP infarction-induced rats exhibited (p < 0.001) improvement heart rate, ECG, biomarker, anti-oxidant levels, no inflammation than pure RSV. assessment on healthy Wistar prolonged circulation (>24 h) compared free drug/s. ability penetrate bio-membranes enter systemic renders them more promising strategy for mitigating MI.

Language: Английский

Synergistic Interactions Between Probiotics and Anticancer Drugs: Mechanisms, Benefits, and Challenges DOI
Babak Pezeshki, Hussein T. Abdulabbas, Asma M. Alturki

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Language: Английский

Citations

1
Probiotics: health benefits, microencapsulation, and viability, combination with natural compounds, and applications in foods DOI
Marcieli Peruzzolo, Giovana Cristina Ceni, Alexander Junges

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106253 - 106253

Published: Feb. 1, 2025

Language: Английский

Citations

1
Crosstalk between ROS-inflammatory gene expression axis in the progression of lung disorders DOI
Sumel Ashique, Neeraj Mishra, Shubhrajit Mantry

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 28, 2024

Language: Английский

Citations

6
Immunomodulatory effects of Lactiplantibacillus plantarum CCFM8661 + stachyose on cyclophosphamide-induced immunosuppression mice DOI Creative Commons
Weiwei Ma, Hang Sun, Lian Lian

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 27, 2025

Introduction The increasing stress of modern life has led to a decline in immunity, sparking widespread interest new strategies boost immune function. Lactiplantibacillus plantarum and stachyose have gained attention for their immune-regulating effects, but the mechanisms combined application remain unclear. This study aims investigate immunoregulatory effects CCFM8661 with cyclophosphamide-induced immunocompromised mice. Methods Mice were divided into normal control group, model group (normal saline), positive drug (levamisole hydrochloride, 10 mg/kg), low, medium, high-dose groups (1.5×10 5 , 1.5×10 6 7 CFU + 1.5 mg stachyose). Each treatment received continuous oral gavage administration 28 days. On days 23 24, except all other intraperitoneally injected cyclophosphamide (40 mg/kg) establish an immunosuppressed model. day 28, 30 minutes after final administration, mice euthanized collect thymus, spleen, serum, ileum, feces subsequent analysis indicators, intestinal barrier function, serum cytokines, microbiota. Results combination significantly improved organ atrophy, restored morphology, normalized cytokine levels mice, indicating enhanced Additionally, it microbiota diversity by abundance Muribaculaceae while reducing Lachnospiraceae potentially promoting homeostasis. Discussion immune-enhancing achieved regulating inflammation maintaining

Language: Английский

Citations

0
Genetic and Molecular Profiling in Merkel Cell Carcinoma: Focus on MCPyV Oncoproteins and Emerging Diagnostic Techniques DOI
H. B. Singh, Sourav Mohanto, Anil Kumar

et al.

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: unknown, P. 155869 - 155869

Published: Feb. 1, 2025

Language: Английский

Citations

0
Silk fibroin: An innovative protein macromolecule-based hydrogel/scaffold revolutionizing breast cancer treatment and diagnosis – Mechanisms, advancements, and targeting capabilities DOI
Shubhrajit Mantry,

Kotaiah Silakabattini,

Prabhat Kumar Das

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142870 - 142870

Published: April 1, 2025

Language: Английский

Citations

0
Development of optimized resveratrol/piperine-loaded phytosomal nanocomplex for isoproterenol-induced myocardial infarction treatment DOI

Thriveni Raunak Salian,

Nadira Noushida, Sourav Mohanto

et al.

Journal of Liposome Research, Journal Year: 2024, Volume and Issue: 34(4), P. 640 - 657

Published: July 12, 2024

Cardiovascular disease is a significant and ever-growing concern, causing high morbidity mortality worldwide. Conventional therapy often very precarious requires long-term usage. Several phytochemicals, including Resveratrol (RSV) Piperine (PIP), possess cardioprotection may be restrained in clinical settings due to inadequate pharmacokinetic properties. Therefore, this study strives develop an optimized RSV phytosomes (RSVP) co-loaded with PIP (RPP) via solvent evaporation method using Box-Behnken design enhance the properties isoproterenol-induced myocardial infarction (MI). The particle size (20.976 ± 0.39 176.53 0.88 nm), zeta potential (−33.33 1.5 −48.7 1.6 mV), drug content (84.57 0.9 87.16 0.6%), %EE (70.56 0.7 67.60 0.57%) of prepared RSVP RPP, respectively demonstrated enhanced solubility control release diffusion media. oral administration RPP infarction-induced rats exhibited (p < 0.001) improvement heart rate, ECG, biomarker, anti-oxidant levels, no inflammation than pure RSV. assessment on healthy Wistar prolonged circulation (>24 h) compared free drug/s. ability penetrate bio-membranes enter systemic renders them more promising strategy for mitigating MI.

Language: Английский

Citations

1