Hallmarks of aging: An expanding universe

Cell, Год журнала: 2023, Номер 186(2), С. 243 - 278

Опубликована: Янв. 1, 2023

Язык: Английский

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Transforming Growth Factor-β Signaling in Fibrotic Diseases and Cancer-Associated Fibroblasts

Biomolecules, Год журнала: 2020, Номер 10(12), С. 1666 - 1666

Опубликована: Дек. 12, 2020

Transforming growth factor-β (TGF-β) signaling is essential in embryo development and maintaining normal homeostasis. Extensive evidence shows that TGF-β activation acts on several cell types, including epithelial cells, fibroblasts, immune to form a pro-fibrotic environment, ultimately leading fibrotic diseases. stored the matrix latent form; once activated, it promotes fibroblast myofibroblast transition regulates extracellular (ECM) formation remodeling fibrosis. can also promote cancer progression through its effects tumor microenvironment. In cancer, contributes generation of cancer-associated fibroblasts (CAFs) have different molecular cellular properties from activated or fibroblasts. CAFs chronic fibrosis via signaling. Fibrosis CAF-mediated share common traits are closely related. this review, we consider how progression. We discuss recent suggesting inhibition as defense against disorders highlight potential implications TGF-β-targeted therapies for cancer.

Язык: Английский

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Gut microbiota-derived tryptophan metabolism mediates renal fibrosis by aryl hydrocarbon receptor signaling activation

Cellular and Molecular Life Sciences, Год журнала: 2020, Номер 78(3), С. 909 - 922

Опубликована: Сен. 23, 2020

Язык: Английский

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Fibrosis: Types, Effects, Markers, Mechanisms for Disease Progression, and Its Relation with Oxidative Stress, Immunity, and Inflammation

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(4), С. 4004 - 4004

Опубликована: Фев. 16, 2023

Most chronic inflammatory illnesses include fibrosis as a pathogenic characteristic. Extracellular matrix (ECM) components build up in excess to cause or scarring. The fibrotic process finally results organ malfunction and death if it is severely progressive. Fibrosis affects nearly all tissues of the body. associated with inflammation, metabolic homeostasis, transforming growth factor-β1 (TGF-β1) signaling, where balance between oxidant antioxidant systems appears be key modulator managing these processes. Virtually every system, including lungs, heart, kidney, liver, can affected by fibrosis, which characterized an excessive accumulation connective tissue components. Organ frequently caused remodeling, also linked high morbidity mortality. Up 45% fatalities industrialized world are damage any organ. Long believed persistently progressing irreversible, has now been revealed very dynamic preclinical models clinical studies variety systems. pathways from and/or main topics this review. Furthermore, different organs their effects was discussed. Finally, we highlight many principal mechanisms fibrosis. These could considered promising targets for development potential therapies important human diseases.

Язык: Английский

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Role of miRNA and lncRNAs in organ fibrosis and aging

Biomedicine & Pharmacotherapy, Год журнала: 2021, Номер 143, С. 112132 - 112132

Опубликована: Сен. 1, 2021

Fibrosis is the endpoint of pathological remodeling. This process contributes to pathogenesis several chronic disorders and aging-associated organ damage. Different molecular cascades contribute this process. TGF-β, WNT, YAP/TAZ signaling pathways have prominent roles in A number long non-coding RNAs microRNAs been found regulate fibrosis through modulation activity related pathways. miR-144-3p, miR-451, miR-200b, miR-328 are among that participate pathology cardiac fibrosis. Meanwhile, miR-34a, miR-17-5p, miR-122, miR-146a, miR-350 liver different situations. PVT1, MALAT1, GAS5, NRON, PFL, MIAT, HULC, ANRIL, H19 We review impact aging-related pathologies.

Язык: Английский

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Traditional Chinese medicine for precancerous lesions of gastric cancer: A review

Biomedicine & Pharmacotherapy, Год журнала: 2021, Номер 146, С. 112542 - 112542

Опубликована: Дек. 20, 2021

Gastric cancer (GC) is the fifth most common type of and third leading cause death due to worldwide. The gastric mucosa often undergoes many years precancerous lesions (PLGC) stages before progressing malignancy. Unfortunately, there are no effective Western drugs for patients with PLGC. In recent years, traditional Chinese medicine (TCM) has been proven in treating Classical TCM formulas chemical components isolated from some herbal medicines have administered treat PLGC, main advantage their comprehensive intervention multiple approaches targets. this review, we focus on studies using treatment including clinical observations experimental research, a targets mechanisms drugs. This review provides ideas theoretical basis applying PLGC prevent GC.

Язык: Английский

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Epigenetic regulation of melanogenesis

Ageing Research Reviews, Год журнала: 2021, Номер 69, С. 101349 - 101349

Опубликована: Май 10, 2021

Язык: Английский

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Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Март 14, 2023

Abstract The ageing process is a systemic decline from cellular dysfunction to organ degeneration, with more predisposition deteriorated disorders. Rejuvenation refers giving aged cells or organisms youthful characteristics through various techniques, such as reprogramming and epigenetic regulation. great leaps in rejuvenation prove that not one-way street, many rejuvenative interventions have emerged delay even reverse the process. Defining mechanism by which roadblocks signaling inputs influence complex programs essential for understanding developing strategies. Here, we discuss intrinsic extrinsic factors counteract cell rejuvenation, targeted core mechanisms involved this Then, critically summarize latest advances state-of-art strategies of rejuvenation. Various methods also provide insights treating specific ageing-related diseases, including reprogramming, removal senescence (SCs) suppression senescence-associated secretory phenotype (SASP), metabolic manipulation, stem cells-associated therapy, dietary restriction, immune heterochronic transplantation, etc. potential applications therapy extend cancer treatment. Finally, analyze detail therapeutic opportunities challenges technology. Deciphering will further into anti-ageing disease treatment clinical settings.

Язык: Английский

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CARDIOVASCULAR DISEASE, SIGNALING, GENE/CELL THERAPY AND ADVANCED NANOBIOMATERIALS

Advances in Biology & Earth Sciences, Год журнала: 2024, Номер 9(Special Issue), С. 58 - 80

Опубликована: Апрель 11, 2024

Cardiovascular biomaterials (also known as CB) are the most common type of biomaterials, both in terms investments and demand. This review article compiles information on CB categorizes it into three primary categories: metals, polymers, biological materials. Blood compatibility is one parameters that restricts use for cardiovascular applications. Within scope this study, a number significant figures concerning blood investigated. There were variety surface modification techniques being utilized at moment order to enhance CB. For purpose gaining deeper comprehension, contemporary applications materials devices also discussed. Last but not least, utilization induced human pluripotent stem cells, endothelization cardiac implants, current trend As result rapid expansion field CB, new researchers academics developing an interest it. overview will serve one-stop shop quickly understanding fundamental studies have been conducted

Язык: Английский

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Fibroageing: An ageing pathological feature driven by dysregulated extracellular matrix-cell mechanobiology

Ageing Research Reviews, Год журнала: 2021, Номер 70, С. 101393 - 101393

Опубликована: Июнь 15, 2021

Ageing is a multifactorial biological process leading to progressive decline of physiological functions. The ageing includes numerous changes in the cells and interactions between cell-cell cell-microenvironment remaining as critical risk factor for development chronic degenerative diseases. Systemic inflammation, known inflammageing, increases consequence contributing age-related morbidities. But also, persistent uncontrolled activation fibrotic pathways, with excessive accumulation extracellular matrix (ECM) organ dysfunction markedly more frequent elderly. In this context, we introduce here concept Fibroageing, that is, propensity develop tissue fibrosis associated ageing, propose ECM key player underlying process. During molecules become damaged through many modifications including glycation, crosslinking, accumulation, stiffness which intensifies ageing-associated alterations. We provide framework some mechanistic hypotheses proposing stiff ECM, addition well-known positive feedback loops, affect several hallmarks such cell senescence mitochondrial dysfunction, mechanism driver thread Fibroageing.

Язык: Английский

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