Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy

Molecular Cancer, Год журнала: 2023, Номер 22(1)

Опубликована: Ноя. 28, 2023

The advent of iPSCs has brought about a significant transformation in stem cell research, opening up promising avenues for advancing cancer treatment. formation is multifaceted process influenced by genetic, epigenetic, and environmental factors. offer distinctive platform investigating the origin cancer, paving way novel approaches to treatment, drug testing, tailored medical interventions. This review article will provide an overview science behind iPSCs, current limitations challenges iPSC-based therapy, ethical social implications, comparative analysis with other types also discuss applications tumorigenesis, future tumorigenesis highlight successful case studies utilizing research. conclusion summarize advancements made research importance continued investment iPSC unlock full potential these cells.

Язык: Английский

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Recent Advances in 3D Printing of Smart Scaffolds for Bone Tissue Engineering and Regeneration

Advanced Materials, Год журнала: 2024, Номер 36(34)

Опубликована: Июнь 11, 2024

The repair and functional reconstruction of bone defects resulting from severe trauma, surgical resection, degenerative disease, congenital malformation pose significant clinical challenges. Bone tissue engineering (BTE) holds immense potential in treating these defects, without incurring prevalent complications associated with conventional autologous or allogeneic grafts. 3D printing technology enables control over architectural structures at multiple length scales has been extensively employed to process biomimetic scaffolds for BTE. In contrast inert grafts, next-generation smart possess a remarkable ability mimic the dynamic nature native extracellular matrix (ECM), thereby facilitating regeneration. Additionally, they can generate tailored controllable therapeutic effects, such as antibacterial antitumor properties, response exogenous and/or endogenous stimuli. This review provides comprehensive assessment progress 3D-printed BTE applications. It begins an introduction physiology, followed by overview technologies utilized scaffolds. Notable advances various stimuli-responsive strategies, efficacy, applications are discussed. Finally, highlights existing challenges development implementation scaffolds, well emerging this field.

Язык: Английский

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Hydrogen sulfide (H2S) metabolism: Unraveling cellular regulation, disease implications, and therapeutic prospects for precision medicine

Nitric Oxide, Год журнала: 2024, Номер 144, С. 20 - 28

Опубликована: Янв. 17, 2024

Язык: Английский

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Epigenetic reprogramming as a key to reverse ageing and increase longevity

Ageing Research Reviews, Год журнала: 2024, Номер 95, С. 102204 - 102204

Опубликована: Янв. 23, 2024

The pursuit for the fountain of youth has long been a fascination amongst scientists and humanity. Ageing is broadly characterized by cellular decline with increased susceptibility to age-related diseases, being intimately associated epigenetic modifications. Recently, reprogramming-induced rejuvenation strategies have begun greatly alter longevity research not only tackle defects but also possibly reverse ageing process. Hence, in this review, we highlight major changes during state-of-art current emerging reprogramming leveraging on transcription factors. Notably, partial enables resetting clock without erasing identity. Promising chemical-based harnessing small molecules, including DNA methyltransferase histone deacetylase inhibitors are discussed. Moreover, parallel interventions, foundations clocks accurate assessment evaluation approaches briefly presented. Going further, such scientific breakthroughs, witnessing rise biotech industry aiming extend health span ideally achieve human one day. In context, overview main scenarios proposed future socio-economic ethical challenges an field. Ultimately, review aims inspire interventions that promote healthy all.

Язык: Английский

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CircRNAs: Pivotal modulators of TGF-β signalling in cancer pathogenesis

Non-coding RNA Research, Год журнала: 2024, Номер 9(2), С. 277 - 287

Опубликована: Янв. 26, 2024

The intricate molecular landscape of cancer pathogenesis continues to captivate researchers worldwide, with Circular RNAs (circRNAs) emerging as pivotal players in the dynamic regulation biological functions. study investigates elusive link between circRNAs and Transforming Growth Factor-β (TGF-β) signalling pathway, exploring their collective influence on progression metastasis. Our comprehensive investigation begins by profiling circRNA expression patterns diverse types, revealing a repertoire intricately linked TGF-β pathway. Through integrated bioinformatics analyses functional experiments, we elucidate specific circRNA-mRNA interactions that modulate signalling, unveiling regulatory controls governing this crucial Furthermore, provide compelling evidence impact circRNA-mediated modulation key cellular processes, including epithelial-mesenchymal transition (EMT), migration, cell proliferation. In addition mechanistic roles, have shown promise diagnostic prognostic biomarkers, well potential targets for therapy. Their ability critical pathways, such axis, underscores significance biology clinical applications. interplay is dissected, uncovering novel circuits contribute complexity biology. This review unravels previously unexplored dimension carcinogenesis, emphasizing role shaping landscape.

Язык: Английский

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Considerations for the development of iPSC-derived cell therapies: A review of key challenges by the JSRM-ISCT iPSC Committee

Cytotherapy, Год журнала: 2024, Номер unknown

Опубликована: Июнь 1, 2024

Since their first production in 2007, human induced pluripotent stem cells (iPSCs) have provided a novel platform for the development of various cell therapies targeting spectrum diseases, ranging from rare genetic eye disorders to cancer treatment. However, several challenges must be tackled iPSC-based therapy enter market and achieve broader global adoption. This white paper, authored by Japanese Society Regenerative Medicine (JSRM) - International Cell Therapy (ISCT) iPSC Committee delves into hurdles encountered pursuit safe economically viable therapies, particularly standpoint industry. It discusses differences guidelines regulatory frameworks, outlines series quality control tests required ensure safety therapy, provides details important considerations around cost goods (COGs), including impact automated advanced manufacturing.

Язык: Английский

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Cellular senescence in cancer: molecular mechanisms and therapeutic targets

MedComm, Год журнала: 2024, Номер 5(5)

Опубликована: Апрель 24, 2024

Abstract Aging exhibits several hallmarks in common with cancer, such as cellular senescence, dysbiosis, inflammation, genomic instability, and epigenetic changes. In recent decades, research into the role of senescence on tumor progression has received widespread attention. While how limits course cancer is well established, also been found to promote certain malignant phenotypes. The tumor‐promoting effect mainly elicited by a senescence‐associated secretory phenotype, which facilitates interaction senescent cells their surroundings. Targeting therefore offers promising technique for therapy. Drugs that pharmacologically restore normal function or eliminate them would assist reestablishing homeostasis cell signaling. Here, we describe its occurrence, impact biology. A “one‐two‐punch” therapeutic strategy first induced, followed use senotherapeutics eliminating introduced. advances application targeting treatment are outlined, an emphasis drug categories, strategies screening, design, efficient targeting. This work will foster thorough comprehension encourage additional within this field.

Язык: Английский

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Molecular insights of exercise therapy in disease prevention and treatment

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Май 29, 2024

Despite substantial evidence emphasizing the pleiotropic benefits of exercise for prevention and treatment various diseases, underlying biological mechanisms have not been fully elucidated. Several attributed to signaling molecules that are released in response by different tissues such as skeletal muscle, cardiac adipose, liver tissue. These molecules, which collectively termed exerkines, form a heterogenous group bioactive substances, mediating inter-organ crosstalk well structural functional tissue adaption. Numerous scientific endeavors focused on identifying characterizing new mediators with properties. Additionally, some investigations molecular targets exerkines cellular cascades trigger adaption processes. A detailed understanding tissue-specific downstream effects is crucial harness health-related mediated improve targeted programs health disease. Herein, we review current vivo exerkine-induced signal transduction across multiple target highlight preventive therapeutic value exerkine diseases. By aspects research, provide comprehensive overview (i) underpinnings secretion, (ii) receptor-dependent receptor-independent adaption, (iii) clinical implications these disease treatment.

Язык: Английский

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Senescence and SASP Are Potential Therapeutic Targets for Ischemic Stroke

Pharmaceuticals, Год журнала: 2024, Номер 17(3), С. 312 - 312

Опубликована: Фев. 28, 2024

Aging is a known co-morbidity of ischemic stroke with its risk and severity increasing every year past 55+. While many the current therapies have shown success in reducing mortality, post-stroke morbidity has not seen same substantial reduction. Recently, involvement cellular senescence SASP brain injury neurological degeneration been recognized. Ischemic causes oxidative stress mitochondrial damage that induces through activation p21 p16 pathways, ultimately leading to synthesis release senescence-associated secretory phenotype (SASP). This event stress-induced premature (SIPS), aging decades beyond standard biological age due an increase senescent cells core ipsilateral hemisphere. Therefore, target SASP, including senolytics, senomorphic drugs, stem cell therapies, other cell-specific interventions, may be new path for treatment.

Язык: Английский

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Advances in Therapy for Urothelial and Non-Urothelial Subtype Histologies of Advanced Bladder Cancer: From Etiology to Current Development

Biomedicines, Год журнала: 2025, Номер 13(1), С. 86 - 86

Опубликована: Янв. 1, 2025

Urothelial carcinoma (UC) is the most common histological subtype of bladder tumors; however, cancer represents a heterogeneous group diseases with at least 40 distinct subtypes. Among these, 2022 World Health Organization classification urinary tract tumors identifies range less subtypes invasive UC, formerly known as variants, which are considered high-grade tumors, including squamous cell, small-cell, sarcomatoid urothelial, micropapillary, plasmacytoid, and urachal carcinomas, adenocarcinoma. Their accurate diagnosis critical for risk stratification therapeutic decision-making, histologies associated poorer outcomes than conventional UC. Despite importance precise diagnosis, high-quality evidence on optimal treatments remains limited owing to their rarity. In particular, neoadjuvant adjuvant chemotherapy have not been well characterized, prospective data scarce. For advanced-stage diseases, clinical trial participation strongly recommended address lack robust evidence. Advances in molecular pathology development targeted therapies immunotherapies reshaped our understanding subtypes, spurring efforts identify predictive biomarkers guide personalized treatment strategies. Nevertheless, management rare subgroups challenging because they frequently excluded from trials. localized disease, curative options such surgical resection or radiotherapy available; become more recurrence metastasis, where systemic therapy primarily used control disease progression palliate symptoms. Herein, we present recent advances urothelial non-urothelial also explore current guiding emphasize challenges perspectives future

Язык: Английский

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