Vaccines,
Год журнала:
2021,
Номер
9(6), С. 679 - 679
Опубликована: Июнь 21, 2021
This
review
describes
investigations
of
specific
topics
that
lie
within
the
general
subject
HSV1’s
role
in
AD/dementia,
published
last
couple
years.
They
include
studies
on
following:
relationship
HSV1
to
AD
using
neural
stem
cells;
apparent
protective
effects
treatment
infection
or
VZV
with
antivirals
prior
onset
dementia;
putative
involvement
AD/dementia;
possible
human
herpes
virus
6
(HHV6)
AD;
seemingly
reduced
risk
dementia
after
vaccination
diverse
types
vaccine,
and
association
shown
some
vaccine
frequency
reactivation;
anti-HSV
serum
antibodies
supporting
linkage
brain
APOE-ε4
carriers,
between
APOE
cognition,
AD/dementia.
The
conclusions
are
there
is
now
overwhelming
evidence
for
role—probably
causal—in
AD,
when
it
present
further
should
be
made
prevention
disease
by
vaccination,
prolonged
antiviral
before
onset.
Journal of Experimental & Clinical Cancer Research,
Год журнала:
2022,
Номер
41(1)
Опубликована: Март 22, 2022
Abstract
Prostate
cancer
is
a
leading
cause
of
death
worldwide
and
new
estimates
revealed
prostate
as
the
in
men
2021.
Therefore,
strategies
are
pertinent
treatment
this
malignant
disease.
Macroautophagy/autophagy
“self-degradation”
mechanism
capable
facilitating
turnover
long-lived
toxic
macromolecules
organelles.
Recently,
attention
has
been
drawn
towards
role
autophagy
how
its
modulation
provides
effective
therapy.
In
present
review,
we
provide
mechanistic
discussion
cancer.
Autophagy
can
promote/inhibit
proliferation
survival
cells.
Besides,
metastasis
cells
affected
(via
induction
inhibition)
by
autophagy.
affect
response
to
therapy
such
chemotherapy
radiotherapy,
given
close
association
between
apoptosis.
Increasing
evidence
demonstrated
that
upstream
mediators
AMPK,
non-coding
RNAs,
KLF5,
MTOR
others
regulate
Anti-tumor
compounds,
for
instance
phytochemicals,
dually
inhibit
or
induce
For
improving
therapy,
nanotherapeutics
chitosan
nanoparticles
have
developed.
With
respect
context-dependent
cancer,
genetic
tools
siRNA
CRISPR-Cas9
be
utilized
targeting
autophagic
genes.
Finally,
these
findings
translated
into
preclinical
clinical
studies
improve
prognosis
patients.
Graphical
abstract
FEBS Letters,
Год журнала:
2022,
Номер
596(9), С. 1095 - 1110
Опубликована: Янв. 28, 2022
Mitochondria
are
associated
with
various
cellular
activities
critical
to
homeostasis,
particularly
in
the
nervous
system.
The
plastic
architecture
of
mitochondrial
network
and
its
dynamic
structure
play
crucial
roles
ensuring
that
varying
energetic
demands
rapidly
met
maintain
neuronal
axonal
energy
homeostasis.
Recent
evidence
associates
aging
neurodegeneration
anomalous
metabolism
as
age‐dependent
alterations
now
believed
occur
prior
neurodegeneration.
brain
has
a
high
demand,
which
makes
it
sensitive
dysfunction.
Distinct
events
causing
oxidative
stress
or
disruption
homeostasis
can
trigger
neuropathology.
This
review
explores
bioenergetic
hypothesis
for
neurodegenerative
pathomechanisms,
discussing
factors
leading
age‐related
hypometabolism
contribution
cognitive
decline.
research
on
healthy
system
cells,
response
stress,
how
is
affected
by
pathology,
well
current
contributions
novel
therapeutic
approaches
will
be
highlighted.
Journal of Neuroinflammation,
Год журнала:
2022,
Номер
19(1)
Опубликована: Окт. 6, 2022
Abstract
Alzheimer's
disease
(AD)
is
the
most
common
neurodegenerative
in
elderly
globally.
Emerging
evidence
has
demonstrated
microglia-driven
neuroinflammation
as
a
key
contributor
to
onset
and
progression
of
AD,
however,
mechanisms
that
mediate
remain
largely
unknown.
Recent
studies
have
suggested
mitochondrial
dysfunction
including
DNA
(mtDNA)
damage,
metabolic
defects,
quality
control
(QC)
disorders
precedes
microglial
activation
subsequent
neuroinflammation.
Therefore,
an
in-depth
understanding
relationship
between
AD
important
unveil
pathogenesis
develop
effective
approaches
for
early
diagnosis
treatment.
In
this
review,
we
summarized
current
progress
roles
mtDNA,
metabolism,
QC
changes
provide
comprehensive
thoughts
targeting
mitochondria
potential
therapeutic
strategies
AD.
Macroautophagy/autophagy
is
an
evolutionally
conserved
catabolic
process
in
which
cytosolic
contents,
such
as
aggregated
proteins,
dysfunctional
organelle,
or
invading
pathogens,
are
sequestered
by
the
double-membrane
structure
termed
autophagosome
and
delivered
to
lysosome
for
degradation.
Over
past
two
decades,
autophagy
has
been
extensively
studied,
from
molecular
mechanisms,
biological
functions,
implications
various
human
diseases,
development
of
autophagy-related
therapeutics.
This
review
will
focus
on
latest
research,
covering
mechanisms
control
biogenesis
autophagosome-lysosome
fusion,
upstream
regulatory
pathways
including
AMPK
MTORC1
pathways.
We
also
provide
a
systematic
discussion
implication
cancer,
neurodegenerative
disorders
(Alzheimer
disease,
Parkinson
Huntington's
Amyotrophic
lateral
sclerosis),
metabolic
diseases
(obesity
diabetes),
viral
infection
especially
SARS-Cov-2
COVID-19,
cardiovascular
(cardiac
ischemia/reperfusion
cardiomyopathy),
aging.
Finally,
we
summarize
pharmacological
agents
that
have
therapeutic
potential
clinical
applications
via
targeting
pathway.
It
believed
decades
hard
work
research
eventually
bring
real
tangible
benefits
improvement
health
diseases.
Molecular Medicine Reports,
Год журнала:
2022,
Номер
26(4)
Опубликована: Авг. 8, 2022
Astaxanthin
is
a
lipid‑soluble
carotenoid
produced
by
various
microorganisms
and
marine
animals,
including
bacteria,
yeast,
fungi,
microalgae,
shrimps
lobsters.
has
antioxidant,
anti‑inflammatory
anti‑apoptotic
properties.
These
characteristics
suggest
that
astaxanthin
health
benefits
protects
against
diseases.
Owing
to
its
ability
cross
the
blood‑brain
barrier,
received
attention
for
protective
effects
neurological
disorders,
Alzheimer's
disease,
Parkinson's
amyotrophic
lateral
sclerosis,
cerebral
ischemia/reperfusion,
subarachnoid
hemorrhage,
traumatic
brain
injury,
spinal
cord
cognitive
impairment
neuropathic
pain.
Previous
studies
on
of
are
mostly
based
animal
models
cellular
experiments.
Thus,
biological
humans
underlying
mechanisms
still
not
fully
understood.
The
present
review
summarizes
neuroprotective
astaxanthin,
explores
action
draws
potential
clinical
implications
as
therapeutic
agent.
Molecular Psychiatry,
Год журнала:
2024,
Номер
29(5), С. 1427 - 1439
Опубликована: Янв. 29, 2024
Abstract
One
mechanism
of
particular
interest
to
regulate
mRNA
fate
post-transcriptionally
is
modification.
Especially
the
extent
m
1
A
methylation
highly
discussed
due
methodological
differences.
However,
one
single
site
in
mitochondrial
ND5
was
unanimously
reported
by
different
groups.
a
subunit
complex
I
respiratory
chain.
It
considered
essential
for
coupling
oxidation
and
proton
transport.
Here
we
demonstrate
that
this
might
be
involved
pathophysiology
Alzheimer’s
disease
(AD).
pathological
hallmarks
neurodegenerative
dysfunction,
mainly
induced
Amyloid
β
(Aβ).
Aβ
disturbs
functions
IV
molecular
dysfunction
still
not
fully
understood.
We
found
enhanced
an
AD
cell
model
as
well
patients.
Formation
catalyzed
increased
TRMT10C
protein
levels,
leading
translation
repression
ND5.
As
consequence,
here
demonstrated
first
time,
leads
dysfunction.
Our
findings
suggest
newly
identified
Aβ-induced
