Foods,
Год журнала:
2025,
Номер
14(3), С. 347 - 347
Опубликована: Янв. 21, 2025
Bee
pollen
is
characterized
by
an
exceptional
diversity
and
abundance
of
micronutrients
bioactive
phytochemicals.
This
richness
remains
very
sparsely
investigated,
but
accumulating
evidence
strongly
supports
a
promising
future
for
bee
in
human
nutrition
medicine.
Epigenetic
regulation
among
the
most
compelling
biomedical
topics
that
remain
completely
untapped
derivative
research.
In
our
current
research,
we
identified
numerous
ubiquitous
compounds
are
consistently
present
this
matrix,
regardless
its
botanical
geographical
origins,
have
been
well
studied
documented
as
epigenetic
regulators
recent
years.
Given
relative
newness
both
research
studies
within
nutritional,
pharmaceutical,
medical
sciences,
review
aims
to
bridge
these
valuable
fields
advance
related
experimental
investigations.
To
best
knowledge,
first
work
has
aimed
comprehensively
investigate
modulatory
potential
compounds.
Our
findings
also
unveiled
several
intriguing
phenomena,
such
dual
effect
same
compound
depending
on
cellular
context
or
some
cross-generational
heritability
traits.
Although
whole
extract
still
lacking,
study
clearly
indicates
avenue
worth
further
We
hope
constitutes
foundational
cornerstone
investigations
Pharmaceutics,
Год журнала:
2025,
Номер
17(1), С. 134 - 134
Опубликована: Янв. 19, 2025
Resveratrol
is
a
natural
polyphenol
(stilbenoid),
which
can
be
found
in
grape
skin,
red
wine,
blueberries,
peanuts
and
others.
The
biological
properties
of
resveratrol,
particular
antioxidant,
anti-inflammatory,
anticancer,
estrogenic,
vasorelaxant
cardioprotective
activity,
are
the
main
reason
for
its
importance
medicine
pharmacy.
Despite
all
advantages,
however,
there
many
problems
related
to
this
polyphenolic
substance,
such
as
low
stability,
water
insolubility,
poor
bioavailability
fast
metabolism.
For
reason,
scientists
currently
searching
different
approaches
dealing
with
these
problematic
improving
therapeutic
usage
resveratrol.
This
review
summarizes
mechanisms
effects
determined
vitro
vivo,
limitations
drug.
article
emphasizes
new
improvement
resveratrol
delivery,
nanoencapsulation,
formation
nanocrystals,
prodrugs
structure
analogues.
Antioxidants,
Год журнала:
2022,
Номер
11(6), С. 1151 - 1151
Опубликована: Июнь 12, 2022
Control
of
excessive
mitochondrial
oxidative
stress
could
provide
new
targets
for
both
preventive
and
therapeutic
interventions
in
the
treatment
chronic
inflammation
or
any
pathology
that
develops
under
an
inflammatory
scenario,
such
as
rheumatoid
arthritis
(RA).
Increasing
evidence
has
demonstrated
role
alterations
autoimmune
diseases
mainly
due
to
interplay
between
metabolism
innate
immunity,
but
also
modulation
response
resident
cells,
synoviocytes.
Thus,
dysfunction
derived
from
several
danger
signals
activate
tricarboxylic
acid
(TCA)
disruption,
thereby
favoring
a
vicious
cycle
oxidative/mitochondrial
stress.
Mitochondrial
can
act
through
modulating
immunity
via
redox-sensitive
pathways
direct
activation
inflammasome.
Besides,
mitochondria
have
central
regulating
cell
death,
which
is
deeply
altered
RA.
Additionally,
multiple
suggests
pathological
processes
RA
be
shaped
by
epigenetic
mechanisms
turn,
are
involved
regulation.
Finally,
we
will
discuss
about
involvement
some
dietary
components
onset
progression
Toxins,
Год журнала:
2022,
Номер
14(11), С. 733 - 733
Опубликована: Окт. 26, 2022
Zearalenone
(ZEA)
is
a
common
mycotoxin
that
induces
oxidative
stress
(OS)
and
affects
the
male
reproductive
system
in
animals.
Resveratrol
(RSV)
has
good
antioxidant
activity
can
activate
nuclear
factor
erythroid
2-related
(Nrf2)
to
protect
cells
through
phosphatidylinositol
3-kinase
(PI3K)/protein
kinase
B
(Akt)
signaling
pathway.
The
objective
of
this
study
was
investigate
protective
effect
mechanism
RSV
on
OS
apoptosis
TM4
induced
by
ZEA.
Prior
being
exposed
ZEA,
were
pretreated
with
or
PI3K/Akt
inhibitor
LY294002.
Cell
viability
measured
Counting
Kit-8
(CCK-8)
assays.
Flow
cytometry
used
determine
level
intracellular
reactive
oxygen
species
(ROS).
expression
poly
ADP-ribose
polymerase
(PARP),
caspase-3,
BCL2-associated
X
(Bax)/B-cell
lymphoma-2
(Bcl-2),
PI3K/Akt-mediated
Nrf2/heme
oxygenase
1
(HO-1)
pathway-related
proteins
evaluated
Western
blotting.
Nrf2
siRNA
transfection
LY294002
treatment
role
Nrf2/HO-1
pathways
alleviation
ZEA-induced
OS.
results
showed
pretreatment
significantly
reduced
apoptosis-related
increased
cell
viability.
Catalase
(CAT)
glutathione
(GSH)
levels
also
increased,
whereas
malondialdehyde
(MDA)
ROS
decreased
(p
<
0.05).
upregulated
Akt
phosphorylation,
translocation,
HO-1
under
conditions
Transfection
abolished
effects
against
cytotoxicity
0.05),
accumulation
completely
blocked
RSV-mediated
increase
translocation
cytoprotective
Collectively,
above
findings
indicate
activation
Journal of Alzheimer s Disease,
Год журнала:
2023,
Номер
96(4), С. 1353 - 1382
Опубликована: Ноя. 7, 2023
Diet
is
an
important
nonpharmacological
risk-modifying
factor
for
Alzheimer's
disease
(AD).
The
approaches
used
here
to
assess
diet's
role
in
the
risk
of
AD
include
multi-country
ecological
studies,
prospective
and
cross-sectional
observational
laboratory
studies.
Ecological
studies
have
identified
fat,
meat,
obesity
from
high-energy
diets
as
factors
reported
that
rates
peak
about
15-20
years
after
national
dietary
changes.
Observational
compared
Western
pattern
with
those
Dietary
Approaches
Stop
Hypertension
(DASH),
Mediterranean
(MedDi),
Mediterranean-DASH
Intervention
Neurodegenerative
Delay
(MIND)
diets.
Those
including
higher
consumption
saturated
total
fats,
ultraprocessed
foods
a
lower
fruits,
legumes,
nuts,
omega-3
fatty
acids,
vegetables,
whole
grains.
Diet-induced
associated
significant
inflammation,
insulin
resistance,
oxidative
stress,
elevated
homocysteine,
advanced
glycation
end
products,
trimethylamine
N-oxide.
molecular
mechanisms
by
which
bioactive
components
specific
affect
are
discussed.
Given
most
countries'
entrenched
food
supply
systems,
upward
trends
would
be
hard
reverse.
However,
people
willing
able,
low-animal
product
diet
plenty
anti-inflammatory,
low-glycemic
load
may
helpful.
Neural Regeneration Research,
Год журнала:
2023,
Номер
19(4), С. 833 - 845
Опубликована: Авг. 14, 2023
A
growing
body
of
evidence
suggests
that
the
gut
microbiota
contributes
to
development
neurodegenerative
diseases
via
microbiota-gut-brain
axis.
As
a
contributing
factor,
dysbiosis
always
occurs
in
pathological
changes
diseases,
such
as
Alzheimer's
disease,
Parkinson's
and
amyotrophic
lateral
sclerosis.
High-throughput
sequencing
technology
has
helped
reveal
bidirectional
communication
between
central
nervous
system
enteric
is
facilitated
by
microbiota's
diverse
microorganisms,
for
both
neuroimmune
neuroendocrine
systems.
Here,
we
summarize
bioinformatics
analysis
wet-biology
validation
metagenomics
with
an
emphasis
on
multi-omics
studies
virome.
The
pathogen-associated
signaling
biomarkers
identifying
brain
disorders
potential
therapeutic
targets
are
also
elucidated.
Finally,
discuss
role
diet,
prebiotics,
probiotics,
postbiotics
exercise
interventions
remodeling
microbiome
reducing
symptoms
diseases.
Alzheimer s & Dementia,
Год журнала:
2023,
Номер
19(8), С. 3701 - 3717
Опубликована: Май 3, 2023
Abstract
This
review
discusses
the
driving
principles
that
may
underlie
neurodegeneration
in
dementia,
represented
most
dominantly
by
Alzheimer's
disease
(AD).
While
a
myriad
of
different
risk
factors
contribute
to
AD,
these
ultimately
converge
common
outcome.
Based
on
decades
research,
picture
emerges
where
upstream
combine
feedforward
pathophysiological
cycle,
culminating
rise
cytosolic
calcium
concentration
([Ca
2+
]
c
)
triggers
neurodegeneration.
In
this
framework,
positive
AD
entail
conditions,
characteristics,
or
lifestyles
initiate
accelerate
self‐reinforcing
cycles
pathophysiology,
whereas
negative
therapeutic
interventions,
particularly
those
mitigating
elevated
[Ca
,
oppose
effects
and
therefore
have
neuroprotective
potential.
Abstract
Senescence
is
a
heterogenous
and
dynamic
process
in
which
various
cell
types
undergo
cell‐cycle
arrest
due
to
cellular
stressors.
While
senescence
has
been
implicated
aging
many
human
pathologies,
therapeutic
interventions
remain
inadequate
the
absence
of
comprehensive
set
biomarkers
context‐dependent
manner.
Polyphenols
have
investigated
as
senotherapeutics
both
preclinical
clinical
settings.
However,
their
use
hindered
by
limited
stability,
toxicity,
modest
bioavailability,
often
concentration
at
target
sites.
To
address
these
limitations,
nanocarriers
such
polymer
nanoparticles
lipid
vesicles
can
be
utilized
enhance
efficacy
senolytic
polyphenols.
Focusing
on
widely
studied
agents—specifically
fisetin,
quercetin,
resveratrol—we
provide
concise
summaries
physical
chemical
properties,
along
with
an
overview
findings.
We
also
highlight
common
signaling
pathways
potential
toxicities
associated
agents.
Addressing
challenges
linked
nanocarriers,
we
present
examples
senotherapeutic
delivery
types,
without
nanocarriers.
Finally,
continued
research
development
agents
are
encouraged
reduce
undesirable
effects
different
organs.
This
review
underscores
need
for
establishing
reliable
sets
that
could
assist
evaluating
effectiveness
current
future
candidates
Antioxidants,
Год журнала:
2024,
Номер
13(5), С. 606 - 606
Опубликована: Май 15, 2024
Epigenetics
defines
changes
in
cell
function
without
involving
alterations
DNA
sequence.
Neuroepigenetics
bridges
neuroscience
and
epigenetics
by
regulating
gene
expression
the
nervous
system
its
impact
on
brain
function.
With
increase
research
recent
years,
it
was
observed
that
did
not
always
originate
from
genetic
sequence,
which
has
led
to
understanding
role
of
neurodegenerative
diseases
(NDDs)
including
Alzheimer's
disease
(AD)
Parkinson's
(PD).
Epigenetic
contribute
aberrant
genes
involved
neuroinflammation,
protein
aggregation,
neuronal
death.
Natural
phytochemicals
have
shown
promise
as
potential
therapeutic
agents
against
NDDs
because
their
antioxidant,
anti-inflammatory,
neuroprotective
effects
cellular
animal
models.
For
instance,
resveratrol
(grapes),
curcumin
(turmeric),
epigallocatechin
gallate
(EGCG;
green
tea)
exhibit
through
influence
methylation
patterns,
histone
acetylation,
non-coding
RNA
profiles.
Phytochemicals
also
aid
slowing
progression,
preserving
function,
enhancing
cognitive
motor
abilities.
The
present
review
focuses
various
epigenetic
modifications
pathology
NDDs,
AD
PD,
regulation
related
alterations,
specific
polyphenols
influencing
PD.
Abstract
Traditional
Chinese
Medicine
(TCM)
is
widely
used
in
clinical
practice
to
treat
diseases
related
central
nervous
system
(CNS)
damage.
However,
the
blood‐brain
barrier
(BBB)
constitutes
a
significant
impediment
effective
delivery
of
TCM,
thus
substantially
diminishing
its
efficacy.
Advances
nanotechnology
and
applications
TCM
(also
known
as
nano‐TCM)
can
deliver
active
ingredients
or
components
across
BBB
targeted
brain
region.
This
review
provides
an
overview
physiological
pathological
mechanisms
systematically
classifies
common
CNS
types
nanocarriers
that
effectively
brain.
Additionally,
drug
strategies
for
nano‐TCMs
utilize
vivo
properties
vitro
devices
bypass
cross
are
discussed.
further
focuses
on
application
treatment
various
diseases.
Finally,
this
article
anticipates
design
strategy
with
higher
efficiency
probes
their
potential
treating
wider
range
