Frontiers in Public Health,
Год журнала:
2025,
Номер
13
Опубликована: Фев. 21, 2025
Dementia
has
emerged
as
a
predominant
health
challenge.
However,
there
is
notable
research
gap
in
the
collective
screening
of
dementia
risks.
Hence,
pressing
need
to
formulate
prediction
tool
tailored
older
adult
demographic,
enabling
identification
high-risk
individuals
for
dementia.
From
May
October
2023,
multi-stage
sampling
method
was
utilized
survey
aged
60
and
above
Weifang.
This
study
employed
Brief
Community
Screening
Instrument
(BCSI-D)
with
We
integrated
biopsychosocial
model
construct
comprehensive
pool
factors
influencing
Employing
least
absolute
shrinkage
selection
operator
multivariate
logistic
regression
analyses,
independent
were
identified
nomogram
model.
Six
hundred
sixty
valid
questionnaires
included
final
analysis,
validity
rate
95.23%.
178
cases
using
BCSI-D.
Napping,
lack
concentration,
self-assessed
status,
education
level,
residence,
social
interaction
medical
insurance
The
efficiency
analysis
model,
constructed
these
factors,
demonstrated
area
under
receiver
operating
characteristic
0.751
training
set
0.794
test
set.
decision
curve
threshold
probabilities
sets
5-60%
1-60%,
respectively.
calibration
curves
both
datasets
exhibited
high
degree
fitting
predicted
curve.
developed
risk
noteworthy
predictive
performance.
proposed
offers
theoretical
data
support
screening.
Alzheimer s & Dementia,
Год журнала:
2023,
Номер
19(7), С. 3171 - 3185
Опубликована: Апрель 19, 2023
Abstract
Introduction
The
projected
growth
of
Alzheimer's
disease
(AD)
and
AD‐related
dementia
(ADRD)
cases
by
midcentury
has
expanded
the
research
field
impelled
new
lines
inquiry
into
structural
social
determinants
health
(S/SDOH)
as
fundamental
drivers
disparities
in
AD/ADRD.
Methods
In
this
review,
we
employ
Bronfenbrenner's
ecological
systems
theory
a
framework
to
posit
how
S/SDOH
impact
AD/ADRD
risk
outcomes.
Results
Bronfenbrenner
defined
“macrosystem”
realm
power
(structural)
that
drive
are
root
cause
disparities.
These
causes
have
been
discussed
little
date
relation
AD/ADRD,
thus,
macrosystem
influences,
such
racism,
classism,
sexism,
homophobia,
emphasis
paper.
Discussion
Under
framework,
highlight
key
quantitative
qualitative
studies
linking
with
identify
scientific
gaps
literature,
propose
guidance
for
future
research.
Highlights
Ecological
links
structural/social
Structural/social
accrue
interact
over
life
course
Macrosystem
is
made
up
societal
norms,
beliefs,
values,
practices
(e.g.,
laws).
Most
macro‐level
understudied
literature.
JAMA Internal Medicine,
Год журнала:
2023,
Номер
183(10), С. 1080 - 1080
Опубликована: Авг. 14, 2023
Emerging
evidence
indicates
that
exposure
to
fine
particulate
matter
(PM2.5)
air
pollution
may
increase
dementia
risk
in
older
adults.
Although
this
suggests
opportunities
for
intervention,
little
is
known
about
the
relative
importance
of
PM2.5
from
different
emission
sources.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(2), С. 1659 - 1659
Опубликована: Янв. 14, 2023
Alzheimer's
disease
(AD)
is
a
multifactorial,
progressive,
neurodegenerative
typically
characterized
by
memory
loss,
personality
changes,
and
decline
in
overall
cognitive
function.
Usually
manifesting
individuals
over
the
age
of
60,
this
most
prevalent
type
dementia
remains
fifth
leading
cause
death
among
Americans
aged
65
older.
While
development
effective
treatment
prevention
for
AD
major
healthcare
goal,
unfortunately,
therapeutic
approaches
to
date
have
yet
find
plan
that
produces
long-term
improvement.
Drugs
may
be
able
slow
down
progression
rate
are
being
introduced
market;
however,
there
has
been
no
previous
solution
preventing
or
reversing
disease-associated
decline.
Recent
studies
identified
several
factors
contribute
severity
disease:
diet,
lifestyle,
stress,
sleep,
nutrient
deficiencies,
mental
health,
socialization,
toxins.
Thus,
increasing
evidence
supports
dietary
other
lifestyle
changes
as
potentially
ways
prevent,
slow,
reverse
progression.
Studies
also
demonstrated
personalized,
multi-therapeutic
approach
needed
improve
metabolic
abnormalities
AD-associated
These
suggest
effects
abnormalities,
such
insulin
resistance,
chronic
inflammation,
hypovitaminosis
D,
hormonal
hyperhomocysteinemia,
process.
Therefore
program
based
on
an
individual's
genetics
biochemistry
preferable
single-drug/mono-therapeutic
approach.
This
article
reviews
these
strategies
identify
attenuate
all
risk
specific
each
affected
individual.
systematically
incorporated
multiple
target
numerous
simultaneously
treat
We
included
high-quality
clinical
trials
observational
focused
programs
comprising
physical,
activity,
well
nutritional
aspects.
Articles
from
PubMed
Central,
Scopus,
Google
Scholar
databases
were
collected,
abstracts
reviewed
relevance
subject
matter.
Epidemiological,
pathological,
toxicological,
genetic,
biochemical
concluded
represents
complex
network
insufficiency.
The
research
explored
manuscript
confirm
need
multifactorial
various
AD.
A
single-drug
delay
loss
but,
date,
not
prevented
reversed
it.
Diet,
physical
environment
disease,
and,
therefore,
multi-factorial
optimization
support
function
offers
rational
strategy.
targets
underlying
more
than
mono-therapeutic
World Psychiatry,
Год журнала:
2024,
Номер
23(2), С. 244 - 256
Опубликована: Май 10, 2024
The
impact
of
air
pollution
and
climate
change
on
mental
health
has
recently
raised
strong
concerns.
However,
a
comprehensive
overview
analyzing
the
existing
evidence
while
addressing
relevant
biases
is
lacking.
This
umbrella
review
systematically
searched
PubMed/Medline,
Scopus
PsycINFO
databases
(up
to
June
26,
2023)
for
any
systematic
with
meta-analysis
investigating
association
or
outcomes.
We
used
R
metaumbrella
package
calculate
stratify
credibility
according
criteria
(i.e.,
convincing,
highly
suggestive,
weak)
that
address
several
biases,
complemented
by
sensitivity
analyses.
included
32
reviews
examined
284
individual
studies
237
associations
exposures
hazards
Most
(n=195,
82.3%)
involved
pollution,
rest
(n=42,
17.7%)
regarded
(mostly
focusing
temperature:
n=35,
14.8%).
Mental
outcomes
in
most
(n=185,
78.1%)
disorders,
followed
suicidal
behavior
(n=29,
12.4%),
access
care
services
(n=9,
3.7%),
disorders-related
symptomatology
(n=8,
3.3%),
multiple
categories
together
(n=6,
2.5%).
Twelve
(5.0%)
achieved
convincing
(class
I)
suggestive
II)
evidence.
Regarding
there
was
between
long-term
exposure
solvents
higher
incidence
dementia
cognitive
impairment
(odds
ratio,
OR=1.139),
some
pollutants
risk
disorders
(higher
high
vs.
low
levels
carbon
monoxide,
CO:
OR=1.587;
vascular
per
1
μg/m
Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Июль 22, 2022
Neurological
disorders
(NDs)
are
one
of
the
leading
causes
global
death.
A
sustained
neuroinflammatory
response
has
been
reported
to
be
associated
with
pathogenesis
multiple
NDs,
including
Parkinson’s
disease
(PD),
sclerosis
(MS),
Alzheimer’s
(AD),
amyotrophic
lateral
(ALS),
and
major
depressive
disorder
(MDD).
Accumulating
evidence
shows
that
recruitment
abundant
lymphocytes
in
central
nervous
system
may
contribute
promoting
development
progress
inflammation
neurological
disorders.
As
subset
T
lymphocytes,
CD4
+
cells
have
a
critical
impact
on
helper
(Th)
17
is
most
studied
Th
subpopulations
produces
cytokines
(e.g.,
IL-17A,
IL-23,
IL-21,
IL-6,
IFN-γ),
abnormal
excessive
activation
microglia
other
immune
cell
types.
All
these
factors
involved
several
However,
possible
mechanisms
Th17
their
immunopathology
abovementioned
not
clarified
completely.
This
review
will
summarize
by
which
encephalitogenic
inflammatory
related
strongly
chronic
neuroinflammation,
thus
perpetuating
neurodegenerative
processes
NDs.
Finally,
potential
therapeutic
prospects
NDs
also
discussed.
Particle and Fibre Toxicology,
Год журнала:
2023,
Номер
20(1)
Опубликована: Ноя. 22, 2023
Microplastics
and
nanoplastics
(MNPs)
are
emerging
environmental
contaminants
detected
in
human
samples,
have
raised
concerns
regarding
their
potential
risks
to
health,
particularly
neurotoxicity.
This
study
aimed
investigate
the
deleterious
effects
of
polystyrene
(PS-NPs,
50
nm)
understand
mechanisms
inducing
Parkinson's
disease
(PD)-like
neurodegeneration,
along
with
exploring
preventive
strategies.
Antioxidants,
Год журнала:
2024,
Номер
13(10), С. 1256 - 1256
Опубликована: Окт. 17, 2024
Environmental
pollution
continues
to
increase
with
industrial
development
and
has
become
a
threat
human
health.
Atmospheric
particulate
matter
(PM)
was
designated
as
Group
1
carcinogen
by
the
International
Agency
for
Research
on
Cancer
in
2013
is
an
emerging
global
environmental
risk
factor
that
major
cause
of
death
related
cardiovascular
respiratory
diseases.
PM
complex
composed
highly
reactive
organic
matter,
chemicals,
metal
components,
which
mainly
excessive
production
oxygen
species
(ROS)
can
lead
DNA
cell
damage,
endoplasmic
reticulum
stress,
inflammatory
responses,
atherosclerosis,
airway
remodeling,
contributing
increased
susceptibility
exacerbation
various
diseases
infections.
effects
health
depending
particle
size,
physical
chemical
characteristics,
source,
exposure
period.
smaller
than
5
μm
penetrate
accumulate
alveoli
circulatory
system,
causing
harmful
skin,
brain.
In
this
review,
we
describe
relationship
mechanism
ROS-mediated
oxidative
responses
caused
organs,
well
comprehensively
discuss
harmfulness
PM.
