Aging and Disease,
Год журнала:
2024,
Номер
unknown, С. 0 - 0
Опубликована: Янв. 1, 2024
Alzheimer's
disease
(AD)
is
an
intricate
neurodegenerative
disorder
characterized
by
the
accumulation
of
misfolded
proteins,
including
beta-amyloid
(Aβ)
and
tau,
leading
to
cognitive
decline.
Despite
decades
research,
precise
mechanisms
underlying
its
onset
progression
remain
elusive.
Cathepsins
are
a
family
lysosomal
enzymes
that
play
vital
roles
in
cellular
processes,
protein
degradation
regulation
immune
responses.
Emerging
evidence
suggests
cathepsins
may
be
involved
AD
pathogenesis.
can
influence
activation
microglia
astrocytes,
resident
cells
brain.
However,
cathepsin
dysfunction
lead
notably
Aβ
tau.
In
addition,
dysregulated
activity
induce
exaggerated
response,
promoting
chronic
inflammation
neuronal
patients
with
AD.
By
unraveling
classification,
functions,
AD's
pathogenesis,
this
review
sheds
light
on
their
involvement
devastating
disease.
Targeting
could
promising
novel
approach
for
mitigating
pathological
processes
contribute
AD,
providing
new
avenues
treatment
prevention.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(19), С. 14499 - 14499
Опубликована: Сен. 24, 2023
Over
the
past
30
years,
majority
of
(pre)clinical
efforts
to
find
an
effective
therapy
for
Alzheimer’s
disease
(AD)
focused
on
clearing
β-amyloid
peptide
(Aβ)
from
brain
since,
according
amyloid
cascade
hypothesis,
was
(and
it
is
still
considered
by
many)
pathogenic
determinant
this
neurodegenerative
disorder.
However,
as
reviewed
in
article,
results
numerous
clinical
trials
that
have
tested
anti-Aβ
therapies
date
indicate
plays
a
minor
role
pathogenesis
AD.
Indeed,
even
Aducanumab
and
Lecanemab,
two
antibodies
recently
approved
FDA
AD
therapy,
well
Donanemab
showed
limited
efficacy
cognitive
parameters
phase
III
trials,
despite
their
capability
markedly
lowering
Aβ
load.
Furthermore,
preclinical
evidence
demonstrates
possesses
several
physiological
functions,
including
memory
formation,
suggesting
may
part
be
due
loss
function
peptide.
Finally,
generally
accepted
could
result
many
molecular
dysfunctions,
therefore,
if
we
keep
chasing
only
Aβ,
means
cannot
see
forest
trees.
Frontiers in Aging Neuroscience,
Год журнала:
2023,
Номер
15
Опубликована: Ноя. 16, 2023
Alzheimer's
disease
(AD)
is
a
prevalent
neurodegenerative
account
for
60-80%
of
the
total
number
people
with
dementia,
but
its
treatment
and
prevention
strategies
are
still
in
long
process
exploration.
It
has
been
reported
that
healthy
lifestyle
may
be
an
effective
non-pharmacological
intervention
AD,
including
increased
physical
activity
consumption
polyphenol-rich
foods.
This
study,
therefore,
investigated
effects
8
weeks
moderate-intensity
aerobic
exercise
(EX),
administration
chlorogenic
acid
(GCA),
combination
both
(EX+GCA)
on
β-amyloid
(Aβ)
deposition,
inflammatory
factors,
oxidative
stress
markers,
neuronal
damage,
cognitive
performance
brains
AD
model
mice
(APP/PS1)
which
signaling
pathways
responsible
these
effects.
The
study
used
Western
blot
to
detect
expression
pathway-related
proteins,
enzyme-linked
immunosorbent
assay
hematoxylin-eosin
staining
hippocampal
morphology,
immunohistochemistry
changes
Aβ
deposition
hippocampus,
marker
kit
status
Morris
water
maze
performance.
showed
8-week
(EX/GCA/EX+GCA)
activating
SIRT1/PGC-1α
pathway
improved
stress,
neuroinflammation,
mice.
However,
there
was
no
obvious
difference
between
EX
GCA
groups.
In
contrast,
combined
EX+GCA
significantly
better
than
phase
or
GCA.
Our
suggests
although
relief
decline
could
also
achieved
GCA,
results.
These
AD-related
conditions
obtained
by
mediating
activation
pathway.
first
explore
improvement
EX+GCA.
candidate
option
AD.
Research on Social Work Practice,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 2, 2025
Purpose:
The
aim
of
this
study
was
to
evaluate
the
effects
a
16-session
multicomponent
intervention
improve
cognitive
abilities
older
adults
with
mild
impairment
(MCI)
through
promotion
healthy
lifestyle,
skills,
tai
chi,
and
mindfulness
exercises
delivered
by
social
worker
6
months
after
intervention.
Method:
This
6-month
follow-up
pilot
randomized
controlled
trial
57
community-dwelling
who
were
randomly
assigned
either
group
(
n
=
30)
or
non-active
control
27).
Results:
Repeated
measures
mixed
linear
model
showed
that
had
significantly
greater
improvement
in
ability
at
post-intervention,
3
compared
group.
Conclusion:
demonstrates
MCI
persisted
up
post-intervention.
Improving
supports
to
enhance
wellbeing
of
people
living
with
dementia
is
a
priority.
Engaging
dementia,
care
partners,
and
other
stakeholders
in
development
interventions
increases
the
likelihood
they
will
be
relevant
impactful.
We
describe
participatory
approach
used
co-design
Dementia
Lifestyle
Intervention
for
Getting
Healthy
Together
(DELIGHT)
program,
which
aims
promote
health
partners.
The
DELIGHT
project
was
guided
by
team
researchers,
an
Alzheimer
Society
representative.
included
additional
exercise
professionals,
dietitians,
community
service
providers
(
n
=
29).
planned
in-person
but
transitioned
six
online,
1.5-h
sessions
due
COVID-19
related
restrictions.
breakout
rooms
discussion,
each
room.
Co-design
meetings
focused
on
identifying
target
population
outcomes
developing
program
components
structure.
Two
or
three
guiding
questions
discussion
meeting.
final
session
overall
structure
program.
Program
resources
were
iteratively
designed
research
team,
external
stakeholders.
result
process
8-week,
twice
weekly
well
Each
includes
50–60
minutes
20–30
facilitated,
shared
learning
associated
resource.
A
healthy
snack
may
offered.
Shared
focuses
eating,
sleeping
well,
mental
well-being,
social
connection,
physical
activity.
Our
vision
that
co-designed
increasing
dementia.
Frontiers in Public Health,
Год журнала:
2025,
Номер
13
Опубликована: Март 18, 2025
To
explore
the
relationship
between
sleep
quality
and
mild
cognitive
impairment
in
older
adult
patients
with
multimorbidity.
The
general
data
of
chronic
diseases
were
collected,
(MCI)
multimorbidity
investigated
by
questionnaire.
Logistic
regression
model
restricted
cubic
spline
(RCS)
used
to
analyze
correlation
MCI
There
are
902
valid
samples
this
study,
which
333
(36.9%)
have
MCI.
number
ranges
from
2
6,
types
medication
0
7.
score
PSQI
is
2-18,
an
average
11.13.
MoCA
range
7-30.
lower
than
that
Non-MCI
patients.
In
all
three
models,
significantly
correlated
results
segmented
analysis
show
that:
inflection
point
MCI's
scoring
12.
RCS
result
display:
increase
score,
OR
increases
MCI,
when
reaches
12,
higher
1.
Sleep
important
influencing
factor
there
a
threshold
effect
above
association.
According
correlation,
health
professionals
can
take
measures
improve
reduce
occurrence
