Development of a nomogram model for predicting dementia risk in the older adult population of Weifang, Shandong Province, China: based on the biopsychosocial model DOI Creative Commons

Pengxin Geng,

Wenjia Feng,

Weiqin Cai

и другие.

Frontiers in Public Health, Год журнала: 2025, Номер 13

Опубликована: Фев. 21, 2025

Dementia has emerged as a predominant health challenge. However, there is notable research gap in the collective screening of dementia risks. Hence, pressing need to formulate prediction tool tailored older adult demographic, enabling identification high-risk individuals for dementia. From May October 2023, multi-stage sampling method was utilized survey aged 60 and above Weifang. This study employed Brief Community Screening Instrument (BCSI-D) with We integrated biopsychosocial model construct comprehensive pool factors influencing Employing least absolute shrinkage selection operator multivariate logistic regression analyses, independent were identified nomogram model. Six hundred sixty valid questionnaires included final analysis, validity rate 95.23%. 178 cases using BCSI-D. Napping, lack concentration, self-assessed status, education level, residence, social interaction medical insurance The efficiency analysis model, constructed these factors, demonstrated area under receiver operating characteristic 0.751 training set 0.794 test set. decision curve threshold probabilities sets 5-60% 1-60%, respectively. calibration curves both datasets exhibited high degree fitting predicted curve. developed risk noteworthy predictive performance. proposed offers theoretical data support screening.

Язык: Английский

Variables associated with cognitive function: an exposome-wide and mendelian randomization analysis DOI Creative Commons
Yongli Zhao, Yizhe Hao,

Yi‐Jun Ge

и другие.

Alzheimer s Research & Therapy, Год журнала: 2025, Номер 17(1)

Опубликована: Янв. 7, 2025

Evidence indicates that cognitive function is influenced by potential environmental factors. We aimed to determine the variables influencing function. Our study included 164,463 non-demented adults (89,644 [54.51%] female; mean [SD] age, 56.69 [8.14] years) from UK Biobank who completed four assessments at baseline. 364 were finally extracted for analysis through a rigorous screening process. performed univariate analyses identify significantly associated with each in two equal-sized split discovery and replication datasets. Subsequently, identified further assessed multivariable model. Additionally, model, we explored associations longitudinal decline. Moreover, one- two- sample Mendelian randomization (MR) conducted confirm genetic associations. Finally, quality of pooled evidence between was evaluated. 252 (69%) exhibited significant least one dataset. Of these, 231 (92%) successfully replicated. our 41 function, spanning categories such as education, socioeconomic status, lifestyle factors, body measurements, mental health, medical conditions, early life household characteristics. Among these variables, 12 more than domain, all subgroup analyses. And LASSO, rigde, principal component indicated robustness primary results. among Furthermore, 22 supported one-sample MR analysis, 5 confirmed two-sample analysis. 10 rated high. Based on adopting favorable 38% 34% decreased risks dementia Alzheimer's disease (AD). Overall, constructed an database which could contribute prevention impairment dementia.

Язык: Английский

Процитировано

1
Environmental Risk Factors for All-Cause Dementia, Alzheimer’s Disease Dementia, Vascular Dementia, and Mild Cognitive Impairment: An Umbrella Review and Meta-Analysis DOI Creative Commons
Aaron Jones, Muhammad Usman Ali, Alexandra Mayhew

и другие.

Environmental Research, Год журнала: 2025, Номер unknown, С. 121007 - 121007

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1
Fine Particulate Matter Triggers α‐Synuclein Fibrillization and Parkinson‐like Neurodegeneration DOI
Xin Yuan,

Yingxu Yang,

Chaoyang Liu

и другие.

Movement Disorders, Год журнала: 2022, Номер 37(9), С. 1817 - 1830

Опубликована: Авг. 22, 2022

ABSTRACT Background The deposition of α‐synuclein (α‐Syn) in the brain is pathological hallmark Parkinson's disease (PD). Epidemiological data indicate that exposure to fine particulate matter (≤2.5 μm aerodynamic diameter [PM2.5]) associated with an increased risk for PD. Objective aim this study investigate whether PM2.5 has a direct effect on α‐Syn pathology and how it drives Methods was added into monomers different cell models test can promote fibrillization aggregation α‐Syn. A53T transgenic mice knockout were used effects PD‐like pathology. Results triggers promotes formation fibrils enhanced seeding activity neurotoxicity. also induces mitochondrial dysfunction oxidative stress. Intrastriatal injection or intranasal administration exacerbates dopaminergic neuronal degeneration mice. detrimental attenuated Conclusions Our results identify could pathology, providing mechanistic insights increases © 2022 International Parkinson Movement Disorder Society.

Язык: Английский

Процитировано

33
Long-Term Exposure to Greenspace and Cognitive Function during the Lifespan: A Systematic Review DOI Open Access
Elisabetta Ricciardi, Giuseppina Spano, Antonella Lopez

и другие.

International Journal of Environmental Research and Public Health, Год журнала: 2022, Номер 19(18), С. 11700 - 11700

Опубликована: Сен. 16, 2022

Recent advances in environmental psychology highlighted the beneficial role of greenspace exposure on cognition. We conducted a systematic review available studies association long-term to and cognitive functions across lifespan. PRISMA guidelines PECOs method were applied screen for eligible studies. Twenty-five from Scopus, PubMed, PsycINFO met inclusion criteria. Six longitudinal nineteen cross-sectional. Fifteen focused schoolchildren, six adults, four elderly. Twenty used NDVI assess remaining other indexes. Eight employed academic achievement as outcome, eight global cognition, attention/executive functions, three memory. The evidence was inconsistent but suggestive functions. Further are required, especially among adults older people, by adopting designs.

Язык: Английский

Процитировано

29
Is Greenness Associated with Dementia? A Systematic Review and Dose–Response Meta-analysis DOI Creative Commons

Federico Zagnoli,

Tommaso Filippini, Marcia Pescador Jimenez

и другие.

Current Environmental Health Reports, Год журнала: 2022, Номер 9(4), С. 574 - 590

Опубликована: Июль 20, 2022

Abstract Purpose of Review We assessed the relation between environmental greenness and risk dementia cognitive impairment, based on a systematic review meta-analysis up to March 30, 2022, characterizing whenever possible shape association using dose–response meta-analysis. Recent Findings Twelve studies were included in this review, either normalized difference vegetation index (NDVI) or land use/cover (LU/LC) methodology assess greenness. Comparing highest versus lowest exposure categories NDVI (6 studies) LU/LC studies), we found no with dementia. Dose–response measured by dementia, only 3 studies, indicated U-shaped association, but estimates imprecise. Summary Our provided some evidence slight inverse at intermediate levels, not high levels. Potential methodological limitations, such as misclassification unmeasured confounding, may have affected results.

Язык: Английский

Процитировано

28
Global ambient particulate matter pollution and neurodegenerative disorders: a systematic review of literature and meta-analysis DOI

Yuting Gong,

Xiaoan Zhang, Xin Zhao

и другие.

Environmental Science and Pollution Research, Год журнала: 2023, Номер 30(14), С. 39418 - 39430

Опубликована: Фев. 10, 2023

Язык: Английский

Процитировано

16
Contributions of neighborhood social environment and air pollution exposure to Black-White disparities in epigenetic aging DOI Creative Commons
Isabel Yannatos, Shana D. Stites, Rebecca T. Brown

и другие.

PLoS ONE, Год журнала: 2023, Номер 18(7), С. e0287112 - e0287112

Опубликована: Июль 5, 2023

Racial disparities in many aging-related health outcomes are persistent and pervasive among older Americans, reflecting accelerated biological aging for Black Americans compared to White, known as weathering. Environmental determinants that contribute weathering poorly understood. Having a higher age, measured by DNA methylation (DNAm), than chronological age is robustly associated with worse age-related social adversity. We hypothesize individual socioeconomic status (SES), neighborhood environment, air pollution exposures racial DNAm according GrimAge Dunedin Pace of Aging (DPoAm). perform retrospective cross-sectional analyses 2,960 non-Hispanic participants (82% 18% Black) the Health Retirement Study whose 2016 linked survey responses geographic data. defined residual after regressing on age. observe individuals have significantly average White (239%) DPoAm (238%). implement multivariable linear regression models threefold decomposition identify this disparity. Exposure measures include individual-level SES, census-tract-level deprivation (fine particulate matter, nitrogen dioxide, ozone), perceived physical disorder. Race gender included covariates. Regression results show SES strongly accounts large portion disparity both aging. Higher contributes more vulnerable fine matter exposure DPoAm, perhaps due individual- neighborhood-level which may play role environment “getting under skin”, contributing between Americans.

Язык: Английский

Процитировано

13
Gut microbiome-based therapies for alleviating cognitive impairment: state of the field, limitations, and future perspectives DOI
Linli Bu, Chen Wang, Junying Bai

и другие.

Food & Function, Год журнала: 2024, Номер 15(3), С. 1116 - 1134

Опубликована: Янв. 1, 2024

Cognitive impairment (CI) is a multifaceted neurological condition that can trigger negative emotions and range of concurrent symptoms, imposing significant public health economic burdens on society.

Язык: Английский

Процитировано

5
Effect of air pollutants particulate matter (PM2.5, PM10), sulfur dioxide (SO2) and ozone (O3) on cognitive health DOI Creative Commons
Sultan Ayoub Meo,

Narmeen Shaikh,

Metib Alotaibi

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Авг. 23, 2024

Impaired cognitive health is the leading cause of various disabilities and disorders. Air pollution has been dramatically increasing over last few decades identified as a potential risk factor for impaired health. This study investigates effect air pollutants, particulate matter (PM2.5, PM10), sulfur dioxide (SO2), ground-level ozone, on global The data environmental pollutants were recorded from PubMed, Web Science, Scopus, Google Scholar. Initially, 790 articles after screening duplicates applying inclusion exclusion criteria, 21 studies included, was synthesized to get pooled result. overall results revealed that increased exposure PM2.5 positively significantly associated with decline (OR 1.49; 95% CI 1.11, 1.99; p = 0.01). impairment due PM10 1.30; 1.00–1.70, 0.05), SO2 1.39; 1.27–1.51; < 0.01) also heightened. findings show PM2.5, PM10, an decrease in functions. suggest reducing levels could be strategic approach mitigate risks populations worldwide.

Язык: Английский

Процитировано

5
Credibility of the evidence on green space and human health: an overview of meta-analyses using evidence grading approaches DOI Creative Commons
Yuting Xie, Shujun Fan, Yana Luo

и другие.

EBioMedicine, Год журнала: 2024, Номер 106, С. 105261 - 105261

Опубликована: Июль 29, 2024

Язык: Английский

Процитировано

4