Modern Rheumatology Journal,
Год журнала:
2024,
Номер
18(2), С. 103 - 110
Опубликована: Апрель 22, 2024
Osteoporosis
(OP)
is
a
common
disease
leading
to
low-trauma
fractures
and
serious
medical
social
problem.
Often
fracture
the
first
clinical
manifestation
of
OP
that
has
been
asymptomatic
for
long
time,
necessitating
development
methods
early
detection
risk
assessment
this
disease.
multifactorial
with
strong
hereditary
component.
However,
as
data
from
study
genetic
factors
show,
only
15%
heritability
trait
can
be
explained.
In
context,
focus
research
shifting
area
epigenetic
regulation,
which
controls
gene
activity
without
altering
primary
structure
DNA.
One
most
promising
mechanisms
control
methylation,
affects
DNA
well
RNA
histones.
The
characteristics
these
possibilities
their
use
diagnosis
treatment
are
presented
in
review.
International Journal of Medical Sciences,
Год журнала:
2023,
Номер
20(2), С. 254 - 261
Опубликована: Янв. 1, 2023
Ischemia-induced
pathological
neovascularization
in
the
retina
is
a
leading
cause
of
blindness
various
age
groups.
The
purpose
current
study
was
to
identify
involvement
circular
RNAs
(circRNAs)
methylated
by
N6-methyladenosine
(m6A),
and
predict
their
potential
roles
oxygen-induced
retinopathy
(OIR)
mice.
Methylation
assessment
via
microarray
analysis
indicated
that
88
circRNAs
were
differentially
modified
m6A
methylation,
including
56
hyper-methylated
32
hypo-methylated
circRNAs.
Gene
ontology
enrichment
predicted
enriched
host
genes
involved
cellular
process,
anatomical
entity,
protein
binding.
Host
regulation
biosynthetic
nucleus,
According
Kyoto
Encyclopedia
Genes
Genomes
analysis,
those
pathways
selenocompound
metabolism,
salivary
secretion,
lysine
degradation.
MeRIP-qPCR
verified
significant
alterations
methylation
levels
mmu_circRNA_33363,
mmu_circRNA_002816,
mmu_circRNA_009692.
In
conclusion,
revealed
modification
OIR
retinas,
findings
above
shed
light
on
circRNA
regulatory
functions
pathogenesis
ischemia-induced
retinal
neovascularization.
Aging,
Год журнала:
2023,
Номер
15(17), С. 8873 - 8907
Опубликована: Сен. 7, 2023
Postmenopausal
osteoporosis
(PMOP)
is
a
prevalent
bone
disorder
with
significant
global
impact.
The
elevated
risk
of
osteoporotic
fracture
in
elderly
women
poses
substantial
burden
on
individuals
and
society.
Unfortunately,
the
current
lack
dependable
diagnostic
markers
precise
therapeutic
targets
for
PMOP
remains
major
challenge.PMOP-related
datasets
GSE7429,
GSE56814,
GSE56815,
GSE147287,
were
downloaded
from
GEO
database.
DEGs
identified
by
"limma"
packages.
WGCNA
Machine
Learning
used
to
choose
key
module
genes
highly
related
PMOP.
GSEA,
DO,
GO,
KEGG
enrichment
analysis
was
performed
all
selected
hub
genes.
PPI
network
constructed
through
GeneMANIA
ROC
curves
AUC
values
validated
both
training
validation
datasets.
xCell
immune
infiltration
single-cell
genes'
function
reaction
Pan-cancer
revealed
role
cancers.A
total
1278
between
patients
healthy
controls.
purple
cyan
as
modules
112
common
after
combining
Five
algorithms
screened
three
(KCNJ2,
HIPK1,
ROCK1),
validate
ROCK1
(AUC
=
0.73)
0.81).
GSEA
low-ROCK1
patients,
top
enriched
field
included
protein
binding
reaction.
DCs
NKT
cells
expressed
showed
correlation
low
expression
SKCM
well
renal
tumors
(KIRP,
KICH,
KIRC).ROCK1
significantly
associated
pathogenesis
PMOP,
influenced
cancer
development,
progression,
prognosis,
which
provided
potential
therapy
target
tumors.
However,
further
laboratory
clinical
evidence
required
before
application
target.
Disease Markers,
Год журнала:
2022,
Номер
2022, С. 1 - 23
Опубликована: Сен. 16, 2022
The
most
frequent
internal
modification
in
eukaryotic
mRNA
is
N6-methyladenosine
(m6A).
However,
what
we
know
about
the
m6A
regulators
Ankylosing
spondylitis
(AS)
still
limited.
In
our
study,
eight
distinct
were
selected
utilizing
Differentially
Expressed
Gene
(DEG)
analysis
of
Expression
Omnibus
GSE73754
dataset
for
making
comparisons
between
AS
(Ankylosing
spondylitis)
and
non-AS
patients.
random
forest
model
nomogram
used
to
screen
candidate
evaluate
their
prediction
accuracy
occurrence
AS.
Furthermore,
based
on
regulators,
patients
divided
into
two
subgroups,
applied
principal
component
algorithms
calculate
score
patterns.
Our
findings
revealed
that
cluster
A
linked
activated
CD4
T
cell
immunity
CD8
immunity.
With
its
major
contributions
area
immunology,
research
patterns
may
benefit
future
diagnosis
treatment
strategies
Modern Rheumatology Journal,
Год журнала:
2024,
Номер
18(2), С. 103 - 110
Опубликована: Апрель 22, 2024
Osteoporosis
(OP)
is
a
common
disease
leading
to
low-trauma
fractures
and
serious
medical
social
problem.
Often
fracture
the
first
clinical
manifestation
of
OP
that
has
been
asymptomatic
for
long
time,
necessitating
development
methods
early
detection
risk
assessment
this
disease.
multifactorial
with
strong
hereditary
component.
However,
as
data
from
study
genetic
factors
show,
only
15%
heritability
trait
can
be
explained.
In
context,
focus
research
shifting
area
epigenetic
regulation,
which
controls
gene
activity
without
altering
primary
structure
DNA.
One
most
promising
mechanisms
control
methylation,
affects
DNA
well
RNA
histones.
The
characteristics
these
possibilities
their
use
diagnosis
treatment
are
presented
in
review.
