Biomedicines,
Год журнала:
2023,
Номер
11(2), С. 442 - 442
Опубликована: Фев. 2, 2023
Heart
failure
with
preserved
ejection
fraction
(HFpEF)
is
a
disease
for
which
there
no
definite
and
effective
treatment,
the
number
of
patients
more
than
50%
heart
(HF)
patients.
Gut
microbiota
(GMB)
general
term
group
living
in
humans’
intestinal
tracts,
has
been
proved
to
be
related
cardiovascular
diseases,
including
HFpEF.
In
HFpEF
patients,
composition
GMB
significantly
changed,
tendency
toward
dysbacteriosis.
Metabolites
GMB,
such
as
trimethylamine
N-oxide
(TMAO),
short-chain
fatty
acids
(SCFAs)
bile
(BAs)
mediate
various
pathophysiological
mechanisms
crucial
influential
factor
inflammation,
considered
one
main
causes
The
role
its
important
comorbidity—metabolic
syndrome—also
mediates
Moreover,
HF
would
aggravate
barrier
impairment
microbial
translocation,
further
promoting
progression.
view
these
mechanisms,
drugs
targeting
may
ways
treat
This
review
focuses
on
interaction
analyzes
potential
therapies.
Frontiers in Genetics,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 13, 2024
Background:
Physical
weakness
and
cardiovascular
risk
increase
significantly
with
age,
but
the
underlying
biological
mechanisms
remain
largely
unknown.
This
study
aims
to
reveal
causal
effect
of
circulating
metabolites
on
frailty,
sarcopenia
vascular
aging
related
traits
diseases
through
a
two-sample
Mendelian
Randomization
(MR)
analysis.
Methods:
Exposures
were
486
analyzed
in
genome-wide
association
(GWAS),
while
outcomes
included
sarcopenia,
arterial
stiffness,
atherosclerosis,
peripheral
disease
(PAD)
aortic
aneurysm.
Primary
estimates
calculated
using
inverse-variance
weighted
(IVW)
method.
Methods
including
MR
Egger,
median,
Q-test,
leave-one-out
analysis
used
for
sensitive
Results:
A
total
125
suggestive
causative
associations
between
identified.
Seven
strong
links
ultimately
identified
six
(kynurenine,
pentadecanoate
(15:0),
1-arachidonoylglycerophosphocholine,
androsterone
sulfate,
glycine
mannose)
three
(sarcopenia,
PAD
atherosclerosis).
Besides,
metabolic
pathway
13
significant
pathways
6
age-related
diseases.
Furthermore,
metabolite-gene
interaction
networks
constructed.
Conclusion:
Our
research
suggested
new
evidence
relationship
diseases,
which
may
hold
promise
as
valuable
biomarkers.
Polymers,
Год журнала:
2025,
Номер
17(3), С. 405 - 405
Опубликована: Фев. 3, 2025
Cardiovascular
risk
is
a
clinical
factor
that
represents
the
probability
of
developing
cardiovascular
diseases
(CVDs).
This
shaped
by
non-modifiable
and
modifiable
factors,
including
dietary
patterns,
which
are
main
lifestyle
influencing
CVD.
Dietary
polysaccharides,
integral
to
nutrition,
have
varying
effects
on
health
depending
their
type
source.
They
include
starches,
non-starch
prebiotic
fibers,
categorized
further
into
soluble
insoluble
fibers.
Soluble
found
in
oats,
legumes,
fruits,
dissolve
water,
forming
gels
help
lower
serum
cholesterol
modulate
blood
glucose
levels.
Insoluble
present
whole
grains
vegetables,
aid
bowel
regularity.
The
benefits
polysaccharides
linked
ability
bind
bile
acids,
reducing
levels,
production
short-chain
fatty
acids
gut
microbiota,
anti-inflammatory
properties.
However,
not
all
beneficial;
refined
starches
can
lead
adverse
metabolic
effects,
chitosan
mixed
microbiota.
review
examines
dualistic
nature
highlighting
beneficial
roles
factors
potential
specific
types.
Cardiovascular Diabetology,
Год журнала:
2025,
Номер
24(1)
Опубликована: Апрель 4, 2025
Heart
failure
with
preserved
ejection
fraction
(HFpEF)
represents
a
significant
and
growing
clinical
challenge.
Initially,
for
an
extended
period,
HFpEF
was
simply
considered
as
subset
of
heart
failure,
manifesting
haemodynamic
disorders
such
hypertension,
myocardial
hypertrophy,
diastolic
dysfunction.
However,
the
rising
prevalence
obesity
diabetes
has
reshaped
phenotype,
nearly
45%
cases
coexisting
diabetes.
Currently,
it
is
recognized
multi-system
disorder
that
involves
heart,
liver,
kidneys,
skeletal
muscle,
adipose
tissue,
along
immune
inflammatory
signaling
pathways.
In
this
review,
we
summarize
landscape
metabolic
rewiring
crosstalk
between
other
organs/systems
(e.g.,
adipose,
gut,
liver
hematopoiesis
system)
in
diabetic
first
instance.
A
diverse
array
metabolites
cytokines
play
pivotal
roles
intricate
process,
rewiring,
chronic
responses,
dysregulation,
endothelial
dysfunction,
fibrosis
identified
central
mechanisms
at
complex
interplay.
The
liver-heart
axis
links
nonalcoholic
steatohepatitis
through
shared
lipid
accumulation,
inflammation,
pathways,
while
gut-heart
dysbiosis-driven
trimethylamine
N-oxide,
indole-3-propionic
acid
short-chain
fatty
acids)
impacting
cardiac
function
inflammation.
Adipose-heart
highlights
epicardial
tissue
source
local
inflammation
mechanical
stress,
whereas
hematopoietic
system
contributes
via
cell
activation
cytokine
release.
We
contend
that,
based
on
viewpoints
expounded
breaking
inter-organ/system
vicious
cycle
linchpin
treating
HFpEF.
Journal of Translational Medicine,
Год журнала:
2023,
Номер
21(1)
Опубликована: Май 25, 2023
Abstract
Cardiovascular
disease
(CVD)
is
the
leading
cause
of
noncommunicable
disease-related
death
worldwide,
and
effective
therapeutic
strategies
against
CVD
are
urgently
needed.
Mitochondria
dysfunction
involves
in
onset
development
CVD.
Nowadays,
mitochondrial
transplantation,
an
alternative
treatment
aimed
at
increasing
number
improving
function,
has
been
emerged
with
great
potential.
Substantial
evidence
indicates
that
transplantation
improves
cardiac
function
outcomes
patients
Therefore,
profound
implications
prevention
Here,
we
review
abnormalities
occur
summarize
for
npj Biofilms and Microbiomes,
Год журнала:
2023,
Номер
9(1)
Опубликована: Окт. 30, 2023
Abstract
There
has
been
an
increase
in
cardiovascular
morbidity
and
mortality
over
the
past
few
decades,
making
disease
(CVD)
leading
cause
of
death
worldwide.
However,
pathogenesis
CVD
is
multi-factorial,
complex,
not
fully
understood.
The
gut
microbiome
long
recognized
to
play
a
critical
role
maintaining
physiological
metabolic
health
host.
Recent
scientific
advances
have
provided
evidence
that
alterations
its
metabolites
profound
influence
on
development
progression
CVD.
Among
trillions
microorganisms
gut,
bifidobacteria,
which,
interestingly,
were
found
through
literature
key
only
regulating
microbiota
function
metabolism,
but
also
reducing
classical
risk
factors
for
(e.g.,
obesity,
hyperlipidemia,
diabetes)
by
suppressing
oxidative
stress,
improving
immunomodulation,
correcting
lipid,
glucose,
cholesterol
metabolism.
This
review
explores
direct
indirect
effects
bifidobacteria
highlights
potential
therapeutic
value
hypertension,
atherosclerosis,
myocardial
infarction,
heart
failure.
By
describing
Bifidobacterium
link
between
microbiology
CVD,
we
aim
provide
theoretical
basis
subsequent
clinical
applications
nutritional
products.
Molecular Nutrition & Food Research,
Год журнала:
2024,
Номер
68(14)
Опубликована: Июнь 22, 2024
Scope
The
microbes
in
breast
milk
are
critical
for
the
early
establishment
of
infant
gut
microbiota
and
have
important
implications
health.
Breast
primarily
derive
from
migration
maternal
intestinal
microbiota.
This
review
suggests
that
regulation
diet
on
may
be
an
effective
strategy
to
improve
Methods
results
article
reviews
impact
development
close
relationship
between
through
entero‐mammary
pathway
is
discussed.
Based
effect
microbiota,
it
proposed
changing
dietary
structure
a
new
regulating
which
would
positive
Conclusion
beneficial
effects
immune
system.
mother's
can
undergo
certain
bacterial
pathway.
Research
has
shown
intervening
during
breastfeeding
affect
composition
thereby
intestines,
closely
related
Abstract
Emerging
evidence
has
demonstrated
the
profound
impact
of
gut
microbiome
on
cardiovascular
diseases
through
production
diverse
metabolites.
Using
an
animal
model
myocardial
ischemia–reperfusion
(I/R)
injury,
we
found
that
prophylactic
administration
a
well‐known
probiotic,
Bifidobacterium
infantis
(
B.
),
exhibited
cardioprotective
effects
in
terms
preserving
cardiac
contractile
function
and
preventing
adverse
remodeling
following
I/R
these
were
recapitulated
by
its
metabolite
inosine.
Transcriptomic
analysis
further
revealed
inosine
mitigated
I/R‐induced
inflammation
cell
death.
Mechanistic
investigations
elucidated
suppressed
pro‐inflammatory
cytokines
reduced
numbers
dendritic
cells
natural
killer
cells,
achieved
activation
adenosine
A2A
receptor
(A2AR)
when
inhibited
abrogated
Additionally,
vitro
studies
using
C2C12
myoblasts
attenuated
death
serving
as
alternative
carbon
source
for
triphosphate
(ATP)
generation
purine
salvage
pathway
subjected
to
oxygen‐glucose
deprivation/reoxygenation
simulated
injury.
Likewise,
reversed
decrease
ATP
levels
mouse
hearts.
Taken
together,
our
findings
indicate
or
exerts
against
suppressing
attenuating
death,
suggesting
therapeutic
options
acute
ischemic
