Molecular Biology Reports, Год журнала: 2025, Номер 52(1)
Опубликована: Май 28, 2025
Язык: Английский
Frontiers in Physiology, Год журнала: 2024, Номер 15
Опубликована: Фев. 28, 2024
Until recently, the study of age-related decline in fertility has focused primarily on ovary; depletion finite pool oocytes and increases meiotic errors leading to oocyte aneuploidy are well-established mechanisms by which declines with advancing age. Comparatively little is known about impact age endometrial function. The endometrium a complex tissue comprised many cell types, including epithelial, stromal, vascular, immune stem cells. capacity this for rapid, cyclic regeneration unique tissue, undergoing repeated cycles growth shedding (in absence an embryo) response ovarian hormones. Furthermore, been shown be capable supporting pregnancies beyond established boundaries reproductive lifespan. Despite its longevity, molecular studies have changes individual populations within endometrium. Human clinical attempted isolate effect aging analyzing conceived euploid, high quality embryos. In review, we explore existing literature pregnancy outcomes. We begin overview principles physiology then behind cellular compartments. Finally, highlight lessons gleaned from rodent human propose opportunities future better understand contribution fertility.
Язык: Английский
Процитировано
3
Obstetrics & Gynecology Science, Год журнала: 2024, Номер 67(4), С. 380 - 392
Опубликована: Апрель 26, 2024
Objective To assess the influence of advanced maternal age on congenital malformations, short- and long-term outcomes in offspring nulligravida.Methods A retrospective study was conducted using Korean National Health Insurance Service database spanning from January 2005 to December 2019. All live-born nulligravida (n=3,685,817) were included. The subdivided into following subgroups: <25 years (n=153,818), 25-29 (n=845,355), 30-34 (n=1,738,299), 35-39 (n=787,530), 40-44 (n=151,519), >44 (n=9,296). Outcomes assessed based International Classification Diseases-10 codes. Adjusted odds ratios (aOR) calculated with group as a reference.Result Most malformations showed an dependent increase, but cleft lip abdominal wall defect exhibited U-shape curve, indicating increase even those old. Similarly, various disorders included neonatal composite short-term aged escalation. However, preterm birth outcome most developmental outcomes, except for motor delay Tics, U-shaped pattern. aOR autism cerebral palsy, showing obvious curved 1.50 (95% confidence interval [CI], 1.24-1.82) 1.54 CI, 1.17-2.03), respectively old 1.18 1.11-1.25) 1.19 1.09-1.30) group.Conclusion Overall, has age-dependent correlation shortand neonates.
Язык: Английский
Процитировано
3
Aging Cell, Год журнала: 2024, Номер 23(11)
Опубликована: Авг. 7, 2024
Maternal age is one of the most important factors affecting success maternal pregnancy. Uterine aging leading cause pregnancy failure in older women. However, how uterine affects receptivity and decidualization unclear. In this study, naturally aged one-year-old female mice were used to investigate effects on embryo implantation during early our we found abnormal mice. Aged mouse uterus indicates a decrease nuclear LAMIN A, an increase PRELAMIN A PROGERIN. uterus, double-stranded DNA (dsDNA) cytoplasmic fraction significantly increased. PROGERIN overexpression epithelial cells organoids leads leakage impaired receptivity. DNase I, II, TREX1 are obviously reduced uterus. Treatments with foreign or STING agonist downregulate markers activate cGAS-STING pathway. estrogen (E
Язык: Английский
Процитировано
3
Archives of Gynecology and Obstetrics, Год журнала: 2024, Номер 310(3), С. 1365 - 1376
Опубликована: Авг. 9, 2024
Язык: Английский
Процитировано
3
ACS Nano, Год журнала: 2024, Номер 18(44), С. 30132 - 30152
Опубликована: Окт. 22, 2024
Infertility is an important issue for human reproductive health, with over half of all cases infertility associated female factors. Dysfunction the complex system may cause infertility. In clinical practice, often treated oral medications and/or surgical procedures, and ultimately assisted technologies. Owing to their excellent biocompatibility, low immunogenicity, adjustable mechanical properties, hydrogels are emerging as valuable tools in reconstruction organ function, supplemented by tissue engineering techniques increase structure functionality. Hydrogel-based strategies targeting pathological mechanisms provide alternatives treatment ovarian, endometrium/uterine, fallopian tube dysfunction. this review, we a general introduction basic physiology pathology system, limitations current treatments, lack translation from animal models physiology. We further overview future potential applications dysfunction, highlighting great prospects hydrogel-based field translational medicine, along significant challenges be overcome.
Язык: Английский
Процитировано
3
Frontiers in Endocrinology, Год журнала: 2024, Номер 15
Опубликована: Ноя. 13, 2024
Ovarian aging is a major health concern for women. associated with reduced span and longevity. Mitochondrial dysfunction one of the hallmarks ovarian aging. In addition to providing oocytes optimal energy, mitochondria provide co-substrate that drives epigenetic processes. Studies show alterations, both nuclear mitochondrial contribute Both, genomes cross-talk each other, resulting in two ways orchestrated anterograde retrograde response involves changes compartments. Epigenetic alterations causing metabolism impact function. Key includes acetyl CoA, NAD+, ATP, α-KG. Thus, enhancing function ovaries may preserve can lead longevity reproductive better outcomes This article describes role mitochondria-led epigenetics involved discusses strategies restore reprogramming by preserving, protecting, or promoting
Язык: Английский
Процитировано
3
Journal of Assisted Reproduction and Genetics, Год журнала: 2025, Номер unknown
Опубликована: Янв. 23, 2025
Язык: Английский
Процитировано
0
Human Reproduction, Год журнала: 2025, Номер unknown
Опубликована: Фев. 21, 2025
Abstract STUDY QUESTION What is the best-performing model currently predicting live birth outcomes for IVF or ICSI? SUMMARY ANSWER Among identified prognostic models, McLernon’s post-treatment outperforms other models in both meta-analysis and external validation of a Chinese cohort. WHAT IS KNOWN ALREADY With numerous similar available across different time periods using various predictors there need to summarize evaluate them, due lack validated evidence distinguishing high-quality from low-quality prediction tools. However, notable dearth research form assessing performance births this field. DESIGN, SIZE, DURATION The researchers conducted comprehensive literature review PubMed, EMBASE, Web Science, keywords related IVF/ICSI outcomes. search included studies published up 3 April 2024, was limited English language studies. PARTICIPANTS/MATERIALS, SETTING, METHODS that developed while providing clear reports on characteristics. Researchers extracted analysed data accordance with guidelines outlined Preferred Reporting Items Systematic Reviews Meta-Analyses model-related guidelines. For effects meta-analysis, choice would be based heterogeneity assessed I2 statistic Cochrane Q test. Model evaluated by their area under receiver operating characteristic curves (AUCs) calibration plots MAIN RESULTS AND THE ROLE OF CHANCE This provides summary derived 72 an overall ROB high unclear. These contained total 132 86 then meta-analyses were performed each five selected models. random Templeton’s, Nelson’s, pre-treatment demonstrated AUCs 0.65 (95% CI: 0.61–0.69), 0.63 0.63–0.64), 0.67 0.62–0.71), 0.73 0.71–0.75), respectively. fixed intelligent analysis score (iDAScore) estimated AUC 0.66 0.63–0.68). initial four our cohort produced ranging 0.53 0.58, confirmed through plots. LIMITATIONS, REASONS FOR CAUTION While focus English-language may constrain generalizability findings diverse populations, approach equips clinicians, who view as ultimate objective, more precise actionable reference WIDER IMPLICATIONS FINDINGS study represents first field definitively confirming superior model. conclusion reinforced independent another perspective. Nevertheless, further investigation warranted develop new externally validate existing high-performing accuracy FUNDING/COMPETING INTEREST(S) supported National Natural Science Foundation China (Grant No. 82174517). authors report no conflict interest. REGISTRATION NUMBER 2022 CRD42022312018.
Язык: Английский
Процитировано
0
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown
Опубликована: Март 6, 2025
ABSTRACT Reproductive aging in females is characterized by a decline oocyte quantity and quality, as well uterine cervical dysfunction that contributes to infertility pregnancy complications. To investigate mechanisms underlying reproductive aging, we explored the contribution of Spag17 , cilia-related gene associated with tissue homeostasis fibrosis. was expressed throughout female tract; however, its expression declined age ovarian tissue, while high levels were observed cervix young during remodeling pre- post-parturition periods. Loss mice resulted impaired fertility, obstructed labor, maternal death. This phenotype accelerated increased fibrosis, stiffness, further complicating parturition. At molecular level, loss activated key aging-associated pathways, including proinflammatory, profibrotic, senescence signaling, suggesting SPAG17 may be critical player aging. TEASER modulator
Язык: Английский
Процитировано
0
Journal of Cellular and Molecular Medicine, Год журнала: 2025, Номер 29(6)
Опубликована: Март 1, 2025
ABSTRACT Endometrium, the lining of uterus, changes dynamically in response to fluctuations ovarian hormones. The proper endocrine environment regulates endometrial functions: menstruation and supporting pregnancy. Obesity is closely related dysfunction, which seriously affects women's health fertility, but pathological mechanism unknown. Chemerin an adipokine involved multiple biological events such as immunity metabolism by acting on its functional receptors. This study aimed characterise effects chemerin human epithelial cells RNA‐Seq. 12Z were utilised model because immunoblot results showed that they expressed markers, markers receptors for chemerin. Principal component analysis (PCA) treatment significantly altered transcriptome. Differential Expression Analysis found 388 significant differentially genes (DEG) group compared with controls. Gene Set Enrichment (GSEA) inhibited lipid induced epithelial‐mesenchymal transition (EMT)‐like process cellular senescence. More importantly, GSEA immunoblots restrained STAT3 signalling pathway, required receptivity establishment. Collectively, these findings provide new evidence over‐produced underlying dysfunctions obesity.
Язык: Английский
Процитировано
0