Drug development & registration,
Год журнала:
2023,
Номер
12(4), С. 53 - 58
Опубликована: Дек. 22, 2023
Introduction.
The
development
of
dosage
forms
sedative
action
is
an
urgent
task
pharmaceutical
technology
in
view
the
prevalence
diseases
nervous
system.
Peony
rhizomes
and
roots
dry
extract
combination
with
glycine
have
a
anxiolytic
effect,
which
associated
improvement
psycho-emotional
state.
Taking
into
account
physicochemical
characteristics
composition
biologically
active
substances
peony
roots,
it
necessary
to
select
auxiliary
that
improve
its
technological
properties.
Aim.
Development
hard
gelatin
capsules
containing
glycine.
Materials
methods.
Objects
research
–
(LLC
"Kazan
Extract
Plant",
Russia),
(JSC
"Biokhimik",
Russia).
Excipients:
apple
pectin
TD
"HIMMED",
starch
aerosil
lactose
microcrystalline
cellulose
basic
magnesium
carbonate
oxide
Results
discussion.
for
obtaining
glycine,
been
substantiated.
quality
indicators
developed
were
determined.
Conclusion.
has
developed,
selected
ensure
satisfactory
properties
mass
filling
capsules.
Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Май 24, 2024
Abstract
Aging
is
a
complex
and
multifaceted
process
involving
variety
of
interrelated
molecular
mechanisms
cellular
systems.
Phenotypically,
the
biological
aging
accompanied
by
gradual
loss
function
systemic
deterioration
multiple
tissues,
resulting
in
susceptibility
to
aging-related
diseases.
Emerging
evidence
suggests
that
closely
associated
with
telomere
attrition,
DNA
damage,
mitochondrial
dysfunction,
nicotinamide
adenine
dinucleotide
levels,
impaired
macro-autophagy,
stem
cell
exhaustion,
inflammation,
protein
balance,
deregulated
nutrient
sensing,
altered
intercellular
communication,
dysbiosis.
These
age-related
changes
may
be
alleviated
intervention
strategies,
such
as
calorie
restriction,
improved
sleep
quality,
enhanced
physical
activity,
targeted
longevity
genes.
In
this
review,
we
summarise
key
historical
progress
exploration
important
causes
anti-aging
strategies
recent
decades,
which
provides
basis
for
further
understanding
reversibility
phenotypes,
application
prospect
synthetic
biotechnology
therapy
also
prospected.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(7), С. 3797 - 3797
Опубликована: Март 28, 2024
The
relentless
pursuit
of
effective
strategies
against
skin
aging
has
led
to
significant
interest
in
the
role
bioactive
factors,
particularly
secondary
metabolites
from
natural
sources.
purpose
this
study
is
meticulously
explore
and
summarize
recent
advancements
understanding
utilization
factors
aging,
with
a
focus
on
their
sources,
mechanisms
action,
therapeutic
potential.
Skin,
largest
organ
body,
directly
interacts
external
environment,
making
it
susceptible
influenced
by
such
as
UV
radiation,
pollution,
oxidative
stress.
Among
various
interventions,
including
peptides,
amino
acids,
metabolites,
have
shown
promising
anti-aging
effects
modulating
biological
pathways
associated
integrity
youthfulness.
This
article
provides
comprehensive
overview
these
compounds,
emphasizing
collagen
antioxidants,
herbal
extracts,
discusses
effectiveness
promoting
synthesis,
enhancing
barrier
function,
mitigating
visible
signs
aging.
By
presenting
synthesis
current
research,
aims
highlight
potential
developing
innovative
care
solutions,
thereby
contributing
broader
field
dermatological
research
offering
new
perspectives
for
future
studies.
Our
findings
underscore
importance
continued
exploration
compounds
revolutionize
improve
health
aesthetics.
Medicinal Research Reviews,
Год журнала:
2024,
Номер
44(4), С. 1904 - 1922
Опубликована: Март 14, 2024
The
pursuit
of
enhanced
health
during
aging
has
prompted
the
exploration
various
strategies
focused
on
reducing
decline
associated
with
process.
A
key
area
this
is
management
mitochondrial
dysfunction,
a
notable
characteristic
aging.
This
review
sheds
light
crucial
role
that
small
molecules
play
in
augmenting
healthy
aging,
particularly
through
influencing
functions.
Mitochondrial
oxidative
damage,
significant
aspect
can
potentially
be
lessened
interventions
such
as
coenzyme
Q10,
alpha-lipoic
acid,
and
variety
antioxidants.
Additionally,
discusses
approaches
for
enhancing
proteostasis,
emphasizing
importance
unfolded
protein
response
inducers
like
doxycycline,
agents
affect
mitophagy,
urolithin
A,
spermidine,
trehalose,
taurine,
which
are
vital
sustaining
quality
control.
Of
equal
methods
modulating
energy
production,
involve
nicotinamide
adenine
dinucleotide
boosters,
adenosine
5'-monophosphate-activated
kinase
activators,
compounds
metformin
mitochondria-targeted
tamoxifen
enhance
metabolic
function.
Furthermore,
delves
into
emerging
encourage
biogenesis.
Together,
these
present
promising
avenue
addressing
age-related
degradation,
thereby
setting
stage
development
innovative
treatment
to
meet
extensive
challenge.
International Journal of Epidemiology,
Год журнала:
2024,
Номер
53(3)
Опубликована: Апрель 4, 2024
Accurate
characterization
of
how
age
influences
body
weight
and
metabolism
at
different
stages
life
is
important
for
understanding
ageing
processes.
Here,
we
explore
observational
longitudinal
associations
between
metabolic
health
from
the
fifth
to
seventh
decade
life,
using
carefully
adjusted
statistical
designs.
International Journal for Parasitology Drugs and Drug Resistance,
Год журнала:
2025,
Номер
27, С. 100578 - 100578
Опубликована: Янв. 5, 2025
Acanthamoeba
castellanii
is
a
widespread
unicellular
eukaryote
found
in
diverse
environments,
including
tap
water,
soil,
and
swimming
pools.
It
responsible
for
severe
infections,
such
as
keratitis
granulomatous
amebic
encephalitis,
particularly
individuals
with
immunocompromisation.
The
ability
of
protozoans
to
form
dormant
persistent
cysts
complicates
treatment,
current
therapies
are
ineffective
against
cyst
stages
suffer
from
poor
specificity
side
effects.
Nitroxoline,
quinoline
derivative
well-established
antibacterial,
antifungal,
antiviral
properties,
promising
therapeutic
candidate.
This
study
aimed
elucidate
cellular
signalling
events
that
counteract
the
effects
nitroxoline.
In
this
study,
nitroxoline
significantly
reduced
viability
A.
trophozoites
dose-
time-dependent
manner,
inducing
morphological
changes
apoptosis.
Transcriptomic
analysis
revealed
substantial
alterations
gene
expression,
enrichment
metabolic
pathways,
DNA
damage
responses,
iron
ion
binding.
Nitroxoline
treatment
upregulated
genes
involved
repair
oxidative
stress
response
while
regulating
methionine
cysteine
cycles.
also
decreased
mitochondrial
membrane
potential,
H₂S
production,
total
amount
castellanii.
Bioinformatic
analyses
molecular
docking
studies
suggest
direct
interactions
between
several
proteins.
Our
research
provides
comprehensive
map
nitroxoline,
revealing
significant
expression
related
pathways.
These
findings
underscore
potential
potent
anti-Acanthamoeba
agent,
offering
new
insights
into
its
mechanism
action
paving
way
effective
combinational
strategies.
Advanced Biology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 17, 2025
Abstract
The
central
dogma
describes
the
unidirectional
flow
of
genetic
information
from
DNA
to
proteins,
leading
an
underappreciation
potential
for
contained
in
proteomes
(the
full
set
proteins
organism)
reflect
broader
biological
processes
such
as
lifespan.
Here,
this
is
addressed
by
examining
how
size
and
composition
276
four
vertebrate
classes
are
related
After
accounting
relationship
between
body
weight
lifespan,
lifespan
negatively
correlated
with
proteome
birds
and,
a
weaker
extent,
fish,
positively
mammals.
Proteome
varies
amongst
classes,
but
there
no
evidence
that
any
specific
amino
acid
findings
relation
role
dietary
restriction
discussed
on
extension
raise
questions
about
evolutionary
structural
forces
shaping
across
species.
Abstract
Aging
is
a
biological
process
along
with
systemic
and
multiple
organ
dysfunction.
It
more
recognized
that
aging
disease
instead
of
single‐organ
functional
disorder.
Systemic
plays
profound
role
in
diseases
including
neurodegenerative
diseases,
cardiovascular
malignant
diseases.
Aged
organs
communicate
other
accelerate
aging.
Skeletal
muscle,
heart,
bone
marrow,
skin,
liver
each
through
organ–organ
crosstalk.
The
crosstalk
can
be
mediated
by
metabolites
lipids,
glucose,
short‐chain
fatty
acids
(SCFA),
inflammatory
cytokines,
exosomes.
Metabolic
disorders
hyperglycemia,
hyperinsulinemia,
hypercholesterolemia
caused
chronic
hallmarks
leads
to
the
destruction
hemostasis,
causes
release
senescence‐associated
secretory
phenotype
(SASP),
imbalance
microbiota
composition.
Released
factors
further
aggregate
senescence,
which
promotes
solid
organs.
Targeting
senescence
or
delaying
emerging
as
critical
health
strategy
for
solving
age‐related
especially
old
population.
In
current
review,
we
will
delineate
mechanisms
provide
therapeutic
targets
