The Journal of Nutritional Biochemistry,
Год журнала:
2025,
Номер
unknown, С. 109842 - 109842
Опубликована: Янв. 1, 2025
Glutamine
availability
may
be
reduced
in
chronic
diseases,
such
as
type
2
diabetes
mellitus
(T2DM)-induced
by
obesity.
Herein,
the
antioxidant,
anti-inflammatory
and
lipid
metabolism
effects
of
oral
glutamine
supplementation
its
free
dipeptide
form
were
assessed
ob/ob
mice.
Adult
male
C57BL/6J
mice
supplemented
with
L-alanyl-L-glutamine
(DIP)
or
L-glutamine
(GLN)
drinking
water
for
40
days,
whilst
Wild-type
lean
(WT)
control
(CTRL)
received
fresh
only.
Plasma
tissue
(skeletal
muscle
liver)
levels,
insulin
resistance
parameters
(e.g.,
GTT,
ITT,
insulin)
determined.
Oxidative
stress
GSH
system,
Nrf2
translocation),
inflammatory
NFkB
translocation,
TNF-α
gene
expression)
plasma
liver
triglyceride
SRBP-1,
FAS,
ACC,
ChRBP
also
analyzed.
CTRL
showed
lower
levels
tissue,
well
increased
fat
liver.
Conversely,
DIP
restored
tissues,
improved
glucose
homeostasis
levels.
Also,
restoration,
expression
was
observed
group.
Interestingly,
GLN
only
stores
but
overall
resistance,
attenuated
metabolic
biomarkers.
The
results
presented
herein
indicate
that
restoration
body
reduces
oxidative
inflammation
obese
T2DM
This
effect
hepatic
changes
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(15), С. 8423 - 8423
Опубликована: Авг. 1, 2024
The
most
abundant
tripeptide—glutathione
(GSH)—and
the
major
GSH-related
enzymes—glutathione
peroxidases
(GPxs)
and
glutathione
S-transferases
(GSTs)—are
highly
significant
in
regulation
of
tumor
cell
viability,
initiation
development,
its
progression,
drug
resistance.
high
level
GSH
synthesis
different
cancer
types
depends
not
only
on
increasing
expression
key
enzymes
γ-glutamyl
cycle
but
also
changes
transport
velocity
precursor
amino
acids.
ability
GPxs
to
reduce
hydroperoxides
is
used
for
cellular
each
member
GPx
family
has
a
mechanism
action
site
maintaining
redox
balance.
GSTs
catalyze
conjugation
electrophilic
substances
reduction
organic
take
part
signaling
pathways.
By
catalyzing
S-glutathionylation
target
proteins,
are
involved
processes,
including
metabolism
(e.g.,
glycolysis
PPP),
signal
transduction,
transcription
regulation,
development
resistance
anticancer
drugs.
In
this
review,
recent
findings
synthesis,
roles
functions
GPxs,
GST
isoforms
discussed,
along
with
search
inhibitors
treatment.
Food and Energy Security,
Год журнала:
2025,
Номер
14(1)
Опубликована: Янв. 1, 2025
ABSTRACT
Specific
light
wavelengths
can
affect
plant
responses
to
pathogens.
In
this
study,
we
investigated
the
soft
rot
resistance
of
lettuce
grown
under
different
conditions
and
analyzed
underlying
molecular
mechanisms
using
RNA‐seq
data.
The
results
revealed
that
blue‐light‐grown
leaves
had
a
better
infection
compared
white
other
conditions,
as
evidenced
by
fewer
symptoms
lower
incidence.
After
infection,
H
2
O
levels
increased
in
all
samples
but
were
lowest
leaves.
Significantly
higher
activities
superoxide
dismutase
(SOD)
catalase
(CAT)
observed
than
white‐light‐grown
regardless
infection.
Transcriptome
analysis
could
activate
maintain
expressions
CAT
SOD
genes,
isochorismate
synthase
pathogenesis‐related
protein
genes
involved
ascorbate‐glutathione
cycle,
photosynthesis‐related
metabolic
pathways
leaves,
which
should
contribute
blue‐light‐induced
resistance.
addition,
found
many
synthesis
signaling
jasmonic
acid
ethylene
significantly
upregulated
after
Thus,
quality
growth
environment
altering
antioxidant
photosynthetic
systems
hormone‐related
pathways,
providing
new
ideas
for
prevention
control
lettuce.
Journal of Cosmetic Dermatology,
Год журнала:
2025,
Номер
24(1)
Опубликована: Янв. 1, 2025
ABSTRACT
Background
Skin
aging
is
inevitable.
Wrinkles,
skin
texture
abnormalities,
senile
hyperpigmentation,
loss
of
tone,
dryness,
atrophy,
and
telangiectasias
represent
some
the
hallmarks
aged
skin.
rejuvenation
can
be
addressed
by
topical
therapies,
such
as
retinoids
antioxidants
or
physical
modalities
with
energy‐based
devices,
all
providing
acceptable
outcomes.
In
this
case
series,
we
aimed
to
test
rejuvenating
potential
combination
cysteamine
(a
naturally
occurring
antioxidant)
isobionicamide
derivative
anti‐aging
molecule
niacinamide)
applied
topically.
Methods
Healthy
male
female
patients
(
N
=
7)
between
25
70
years
having
Fitzpatrick
types
I–VI
were
recruited.
Topical
application
a
cysteamine‐isobionicamide
formula
was
done
once
daily.
Treatment
lasted
for
16
weeks.
Clinical
high‐resolution
photos
acquired
using
LifeViz
3D
at
recruitment
after
Blinded
dermatological
examinations
scoring
performed.
Self‐assessment
quality
life
(QoL)
questionnaires
collected.
Results
showed
improvement
in
luminosity,
increased
evenness
reduction
fine
wrinkles
well
hyperpigmentation.
Patients
clinical
investigators
blinded
chronology
observed
improvements
texture,
radiance,
brightening
dark
spots,
both
number
volume
weeks
daily
application.
Furthermore,
significant
patients'
recorded.
Conclusion
This
series
represents
first
evidence
that
isobionic‐amide
complex
could
considered
safe
effective
option
reversal
photoaging.
Pharmaceuticals,
Год журнала:
2025,
Номер
18(2), С. 216 - 216
Опубликована: Фев. 6, 2025
Background:
Tramadol,
a
weak
opioid
analgesic
agent,
is
known
to
induce
ovarian
damage.
Previous
studies
have
held
oxidative
stress
responsible
for
the
adverse
effects
of
tramadol
on
female
reproduction.
This
study
examined
protective
ATP
against
tramadol-induced
damage
and
reproductive
dysfunction
in
rats.
Methods:
Rats
were
divided
into
four
groups
(n
=
12);
healthy
(HG),
only
(ATPG),
(TMDG),
+
(ATMG).
was
injected
intraperitoneally
at
25
mg/kg.
Tramadol
50
mg/kg
initiated
one
hour
after
ATP.
The
treatment
administered
once
day
14
days.
Six
rats
from
each
group
euthanized.
For
two
months,
remaining
paired
with
male
that
failed
give
birth
during
this
period
considered
infertile.
A
maternity
calculated
delivered.
Results:
caused
an
increase
malondialdehyde
interleukin-6,
decreased
total
glutathione,
superoxide
dismutase,
catalase
levels
tissue.
Furthermore,
disrupted
histological
structure
ovaries,
immunohistochemical
staining
revealed
severe
immunopositivity.
again
infertility
delayed
pregnancy
fertile
women.
By
suppressing
biochemical
changes,
significantly
reduced
Both
histopathologically
immunohistochemically,
regressed
Additionally,
maternal
delay.
Conclusions:
results
indicate
inflammatory
injury,
infertility,
caspase
3
suppressed
by
ATP,
as
demonstrated
our
experimental
findings.
BioScience Trends,
Год журнала:
2024,
Номер
18(2), С. 153 - 164
Опубликована: Апрель 9, 2024
NAD(P)H-quinone
oxidoreductase
1
(NQO1)
is
an
essential
redox
enzyme
responsible
for
balance
and
energy
metabolism.
Despite
of
its
importance,
the
brain
contains
high
capacity
polyunsaturated
fatty
acids
maintains
low
levels
NQO1
expression.
In
this
study,
we
examined
how
expression
affects
cell
survival
in
response
to
toxic
insults
causing
mitochondrial
dysfunction
ferroptosis,
whether
has
a
potential
as
biomarker
different
stressed
conditions.
Following
treatment
with
rotenone,
overexpressed
SH-SY5Y
cells
improved
by
reducing
reductive
stress
via
increased
NAD
