Exploring Retinal Neurodegeneration in Alzheimer’s Disease: A Molecular and Cellular Perspective

Neurotoxicity Research, Год журнала: 2025, Номер 43(2)

Опубликована: Апрель 1, 2025

Язык: Английский

---

Unraveling the Immune Puzzle: Role of Immunomodulation in Alzheimer’s Disease

Journal of Neuroimmune Pharmacology, Год журнала: 2025, Номер 20(1)

Опубликована: Апрель 29, 2025

Язык: Английский

---

Design, Synthesis, and Biological Evaluation of Imidazolylacetophenone Oxime Derivatives as Novel Brain-Penetrant Agents for Alzheimer’s Disease Treatment

European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 278, С. 116794 - 116794

Опубликована: Авг. 30, 2024

Язык: Английский

---

Association Between the Gut Microbiota and Alzheimer’s Disease: An Update on Signaling Pathways and Translational Therapeutics

Molecular Neurobiology, Год журнала: 2024, Номер 62(4), С. 4499 - 4519

Опубликована: Окт. 26, 2024

Язык: Английский

---

Decoding Paradoxical Links of Cytokine Markers in Cognition: Cross talk between Physiology, Inflammaging, and Alzheimer’s Disease- Related Cognitive Decline

Ageing Research Reviews, Год журнала: 2024, Номер 101, С. 102535 - 102535

Опубликована: Окт. 6, 2024

Язык: Английский

---

From Plaques to Pathways in Alzheimer’s Disease: The Mitochondrial-Neurovascular-Metabolic Hypothesis

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(21), С. 11720 - 11720

Опубликована: Окт. 31, 2024

Alzheimer's disease (AD) presents a public health challenge due to its progressive neurodegeneration, cognitive decline, and memory loss. The amyloid cascade hypothesis, which postulates that the accumulation of amyloid-beta (Aβ) peptides initiates leading AD, has dominated research therapeutic strategies. failure recent Aβ-targeted therapies yield conclusive benefits necessitates further exploration AD pathology. This review proposes Mitochondrial-Neurovascular-Metabolic (MNM) integrates mitochondrial dysfunction, impaired neurovascular regulation, systemic metabolic disturbances as interrelated contributors pathogenesis. Mitochondrial hallmark leads oxidative stress bioenergetic failure. Concurrently, breakdown blood-brain barrier (BBB) cerebral blood flow, characterize dysregulation, accelerate neurodegeneration. Metabolic such glucose hypometabolism insulin resistance impair neuronal function survival. hypothesis highlights interconnectedness these pathways suggests strategies targeting health, integrity, regulation may offer more effective interventions. MNM addresses multifaceted aspects providing comprehensive framework for understanding progression developing novel approaches. approach paves way innovative could significantly improve outcomes millions affected worldwide.

Язык: Английский

---

Shedding light on microglial dysregulation in Alzheimer’s disease: exploring molecular mechanisms and therapeutic avenues

Inflammopharmacology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 28, 2024

Язык: Английский

---